PJA2

PJA2
Identifiers
Aliases	PJA2 , Neurodap1, RNF131, praja ring finger ubiquitin ligase 2
External IDs	MGI: 2159342; HomoloGene: 32233; GeneCards: PJA2; OMA:PJA2 - orthologs
Gene location (Human) Chr. Chromosome 5 (human) [1] Band 5q21.3 Start 109,334,713 bp [1] End 109,409,974 bp [1]
Gene location (Mouse) Chr. Chromosome 17 (mouse) [2] Band 17|17 E1.1 Start 64,588,000 bp [2] End 64,638,911 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tail of epididymis postcentral gyrus frontal pole Achilles tendon Brodmann area 46 prefrontal cortex orbitofrontal cortex pons caput epididymis superior vestibular nucleus Top expressed in interventricular septum medial dorsal nucleus dorsal striatum temporal lobe olfactory tubercle globus pallidus inferior colliculi facial motor nucleus Region I of hippocampus proper nucleus accumbens More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein kinase A regulatory subunit binding ubiquitin-protein transferase activity protein kinase A catalytic subunit binding ubiquitin protein ligase activity metal ion binding transferase activity protein binding Cellular component Golgi membrane postsynaptic density membrane endoplasmic reticulum synapse plasma membrane cytoplasm cell junction postsynaptic membrane Golgi apparatus intermediate filament cytoskeleton endoplasmic reticulum membrane Biological process hippo signaling regulation of protein kinase A signaling long-term memory protein ubiquitination inflammatory response positive regulation of toll-like receptor 2 signaling pathway regulation of macrophage activation innate immune response positive regulation of JNK cascade positive regulation of p38MAPK cascade Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9867 224938 Ensembl ENSG00000198961 ENSMUSG00000024083 UniProt O43164 Q80U04 RefSeq (mRNA) NM_014819 NM_001025309 NM_144859 RefSeq (protein) NP_055634 NP_001020480 NP_659108 Location (UCSC) Chr 5: 109.33 – 109.41 Mb Chr 17: 64.59 – 64.64 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

E3 ubiquitin-protein ligase Praja2 is an enzyme that in humans is encoded by the PJA2 gene. ^[5]

Interactions

PJA2 has been shown to interact with UBE2D2. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000198961 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024083 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: PJA2 praja 2, RING-H2 motif containing".
6. Yu P, Chen Y, Tagle DA, Cai T (June 2002). "PJA1, encoding a RING-H2 finger ubiquitin ligase, is a novel human X chromosome gene abundantly expressed in brain". Genomics. 79 (6): 869–74. doi:10.1006/geno.2002.6770. PMID   12036302.

Further reading

• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.
• Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S (September 2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Research. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC   515316 . PMID   15342556.
• Yu P, Chen Y, Tagle DA, Cai T (June 2002). "PJA1, encoding a RING-H2 finger ubiquitin ligase, is a novel human X chromosome gene abundantly expressed in brain". Genomics. 79 (6): 869–74. doi:10.1006/geno.2002.6770. PMID   12036302.
• Sasaki A, Masuda Y, Iwai K, Ikeda K, Watanabe K (June 2002). "A RING finger protein Praja1 regulates Dlx5-dependent transcription through its ubiquitin ligase activity for the Dlx/Msx-interacting MAGE/Necdin family protein, Dlxin-1". The Journal of Biological Chemistry. 277 (25): 22541–6. doi: 10.1074/jbc.M109728200 . PMID   11959851.
• Ishikawa K, Nagase T, Nakajima D, Seki N, Ohira M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (October 1997). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 4 (5): 307–13. doi: 10.1093/dnares/4.5.307 . PMID   9455477.
• Mishra L, Tully RE, Monga SP, Yu P, Cai T, Makalowski W, Mezey E, Pavan WJ, Mishra B (November 1997). "Praja1, a novel gene encoding a RING-H2 motif in mouse development". Oncogene. 15 (19): 2361–8. doi: 10.1038/sj.onc.1201405 . PMID   9393880.
• Bonaldo MF, Lennon G, Soares MB (September 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.
• Nakayama M, Miyake T, Gahara Y, Ohara O, Kitamura T (July 1995). "A novel RING-H2 motif protein downregulated by axotomy: its characteristic localization at the postsynaptic density of axosomatic synapse". The Journal of Neuroscience. 15 (7 Pt 2): 5238–48. doi:10.1523/JNEUROSCI.15-07-05238.1995. PMC   6577874 . PMID   7623148.