PLA2G12A

PLA2G12A
Identifiers
Aliases	PLA2G12A , GXII, PLA2G12, ROSSY, phospholipase A2 group XIIA
External IDs	OMIM: 611652; MGI: 1913600; HomoloGene: 11328; GeneCards: PLA2G12A; OMA:PLA2G12A - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	109,730,070 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	129,689,474 bp
RNA expression pattern
	Top expressed in
	skin of arm; ; endothelial cell; ; cardiac muscle tissue of right atrium; ; myocardium of left ventricle; ; inferior ganglion of vagus nerve; ; renal medulla; ; pons; ; medulla oblongata; ; parietal pleura; ; subthalamic nucleus;
	Top expressed in
	Ileal epithelium; ; plantaris muscle; ; interventricular septum; ; soleus muscle; ; parotid gland; ; extensor digitorum longus muscle; ; extraocular muscle; ; lacrimal gland; ; thoracic diaphragm; ; ankle joint;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium ion binding ; calcium-dependent phospholipase A2 activity ; metal ion binding ; hydrolase activity ; phospholipase A2 activity ;
Cellular component	cytoplasm ; Golgi apparatus ; intracellular anatomical structure ; extracellular region ; endoplasmic reticulum ;
Biological process	phosphatidic acid biosynthetic process ; phosphatidylserine acyl-chain remodeling ; phosphatidylethanolamine acyl-chain remodeling ; lipid metabolism ; phosphatidylinositol acyl-chain remodeling ; lipid catabolic process ; phosphatidylglycerol acyl-chain remodeling ; phosphatidylcholine acyl-chain remodeling ; phospholipid metabolic process ; arachidonic acid secretion ; biological process ;
	Sources:Amigo / QuickGO
Orthologs
	81579
	66350
	ENSG00000123739
	ENSMUSG00000027999
	Q9BZM1 ; Q542Y6
	Q9EPR2
	NM_030821
	NM_001286948 ; NM_023196 ; NM_183423
	NP_110448 ; NP_110448.2
	NP_001273877 ; NP_075685 ; NP_904359
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated September 21, 2024

Group XIIA secretory phospholipase A₂ is an enzyme that in humans is encoded by the PLA2G12A gene.^[5]^[6]

Related Research Articles

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Cytosolic phospholipase A₂ gamma is an enzyme that in humans is encoded by the PLA2G4C gene.

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Group IID secretory phospholipase A₂ is an enzyme that in humans is encoded by the PLA2G2D gene.

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GPI transamidase component PIG-S is an enzyme that in humans is encoded by the PIGS gene. This gene encodes a protein that is involved in GPI-anchor biosynthesis.

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Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 3 is an enzyme that in humans is encoded by the NDST3 gene. It catalyses the reaction:

3'-phosphoadenylyl sulfate + α-D-glucosaminyl-[heparan sulfate]_(n) = adenosine 3',5'-bisphosphate + 2 H⁺ + N-sulfo-α-D-glucosaminyl-[heparan sulfate]_(n)

SEC23-interacting protein is a protein that in humans is encoded by the SEC23IP gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000123739 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027999 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Gelb MH, Valentin E, Ghomashchi F, Lazdunski M, Lambeau G (Jan 2001). "Cloning and recombinant expression of a structurally novel human secreted phospholipase A2". J Biol Chem. 275 (51): 39823–6. doi: 10.1074/jbc.C000671200 . PMC 3422575 . PMID 11031251.
↑ "Entrez Gene: PLA2G12A phospholipase A2, group XIIA".

Schröder HC, Perovic S, Kavsan V, et al. (1998). "Mechanisms of prionSc- and HIV-1 gp120 induced neuronal cell death". Neurotoxicology. 19 (4–5): 683–8. PMID 9745929.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi: 10.1093/dnares/12.2.117 . PMID 16303743.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Rouault M, Bollinger JG, Lazdunski M, et al. (2003). "Novel mammalian group XII secreted phospholipase A2 lacking enzymatic activity". Biochemistry. 42 (39): 11494–503. doi:10.1021/bi0349930. PMID 14516201.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697 . PMID 12975309.
Murakami M, Masuda S, Shimbara S, et al. (2003). "Cellular arachidonate-releasing function of novel classes of secretory phospholipase A2s (groups III and XII)". J. Biol. Chem. 278 (12): 10657–67. doi: 10.1074/jbc.M211325200 . PMID 12522102.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Ho IC, Arm JP, Bingham CO, et al. (2001). "A novel group of phospholipase A2s preferentially expressed in type 2 helper T cells". J. Biol. Chem. 276 (21): 18321–6. doi: 10.1074/jbc.M008837200 . PMID 11278438.
Mavoungou E, Georges-Courbot MC, Poaty-Mavoungou V, et al. (1997). "HIV and SIV envelope glycoproteins induce phospholipase A2 activation in human and macaque lymphocytes". J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 16 (1): 1–9. doi: 10.1097/00042560-199709010-00001 . PMID 9377118.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000123739 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027999 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11031251-5] Gelb MH, Valentin E, Ghomashchi F, Lazdunski M, Lambeau G (Jan 2001). "Cloning and recombinant expression of a structurally novel human secreted phospholipase A2". J Biol Chem. 275 (51): 39823–6. doi: 10.1074/jbc.C000671200 . PMC 3422575 . PMID 11031251.

[entrez-6] "Entrez Gene: PLA2G12A phospholipase A2, group XIIA".

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PLA2G12A

Contents

See also

Related Research Articles

References

Further reading