PLA2G12A

PLA2G12A
Identifiers
Aliases	PLA2G12A , GXII, PLA2G12, ROSSY, phospholipase A2 group XIIA
External IDs	OMIM: 611652; MGI: 1913600; HomoloGene: 11328; GeneCards: PLA2G12A; OMA:PLA2G12A - orthologs
Gene location (Human) Chr. Chromosome 4 (human) [1] Band 4q25 Start 109,709,989 bp [1] End 109,730,070 bp [1]
Gene location (Mouse) Chr. Chromosome 3 (mouse) [2] Band 3|3 G3 Start 129,672,255 bp [2] End 129,689,474 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of arm endothelial cell cardiac muscle tissue of right atrium myocardium of left ventricle inferior ganglion of vagus nerve renal medulla pons medulla oblongata parietal pleura subthalamic nucleus Top expressed in Ileal epithelium plantaris muscle interventricular septum soleus muscle parotid gland extensor digitorum longus muscle extraocular muscle lacrimal gland thoracic diaphragm ankle joint More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding calcium-dependent phospholipase A2 activity metal ion binding hydrolase activity phospholipase A2 activity Cellular component cytoplasm Golgi apparatus intracellular anatomical structure extracellular region endoplasmic reticulum Biological process phosphatidic acid biosynthetic process phosphatidylserine acyl-chain remodeling phosphatidylethanolamine acyl-chain remodeling lipid metabolism phosphatidylinositol acyl-chain remodeling lipid catabolic process phosphatidylglycerol acyl-chain remodeling phosphatidylcholine acyl-chain remodeling phospholipid metabolic process arachidonic acid secretion biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 81579 66350 Ensembl ENSG00000123739 ENSMUSG00000027999 UniProt Q9BZM1 Q542Y6 Q9EPR2 RefSeq (mRNA) NM_030821 NM_001286948 NM_023196 NM_183423 RefSeq (protein) NP_110448 NP_110448.2 NP_001273877 NP_075685 NP_904359 Location (UCSC) Chr 4: 109.71 – 109.73 Mb Chr 3: 129.67 – 129.69 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Group XIIA secretory phospholipase A₂ is an enzyme that in humans is encoded by the PLA2G12A gene. ^{[5] [6]}

See also

• Phospholipase A₂

References

1. GRCh38: Ensembl release 89: ENSG00000123739 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027999 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Gelb MH, Valentin E, Ghomashchi F, Lazdunski M, Lambeau G (Jan 2001). "Cloning and recombinant expression of a structurally novel human secreted phospholipase A2". J Biol Chem. 275 (51): 39823–6. doi: 10.1074/jbc.C000671200 . PMC   3422575 . PMID   11031251.
6. "Entrez Gene: PLA2G12A phospholipase A2, group XIIA".

Further reading

• Schröder HC, Perovic S, Kavsan V, et al. (1998). "Mechanisms of prionSc- and HIV-1 gp120 induced neuronal cell death". Neurotoxicology. 19 (4–5): 683–8. PMID   9745929.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi: 10.1093/dnares/12.2.117 . PMID   16303743.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Rouault M, Bollinger JG, Lazdunski M, et al. (2003). "Novel mammalian group XII secreted phospholipase A2 lacking enzymatic activity". Biochemistry. 42 (39): 11494–503. doi:10.1021/bi0349930. PMID   14516201.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC   403697 . PMID   12975309.
• Murakami M, Masuda S, Shimbara S, et al. (2003). "Cellular arachidonate-releasing function of novel classes of secretory phospholipase A2s (groups III and XII)". J. Biol. Chem. 278 (12): 10657–67. doi: 10.1074/jbc.M211325200 . PMID   12522102.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ho IC, Arm JP, Bingham CO, et al. (2001). "A novel group of phospholipase A2s preferentially expressed in type 2 helper T cells". J. Biol. Chem. 276 (21): 18321–6. doi: 10.1074/jbc.M008837200 . PMID   11278438.
• Mavoungou E, Georges-Courbot MC, Poaty-Mavoungou V, et al. (1997). "HIV and SIV envelope glycoproteins induce phospholipase A2 activation in human and macaque lymphocytes". J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 16 (1): 1–9. doi: 10.1097/00042560-199709010-00001 . PMID   9377118.