Phospholipase A2, group 1B is an enzyme that in humans is encoded by the PLA2G1B gene. [5] [6]
Phospholipase A2, group 1B is an enzyme that in humans is encoded by the PLA2G1B gene. [5] [6]
Phospholipase A2 (EC 3.1.1.4) catalyzes the release of fatty acids from glycero-3-phosphocholines. The best known varieties are the digestive enzymes secreted as zymogens by the pancreas of mammals as well as fish. [7] Sequences of pancreatic PLA2 enzymes from a variety of mammals have been reported. One striking feature of these enzymes is their close homology to venom phospholipases of snakes. Other forms of PLA2 have been isolated from brain, liver, lung, spleen, intestine, macrophages, leukocytes, erythrocytes, inflammatory exudates, chondrocytes, and platelets (Seilhamer et al., 1986) . [6] [8]
Colipase, abbreviated CLPS, is a protein co-enzyme required for optimal enzyme activity of pancreatic lipase. It is secreted by the pancreas in an inactive form, procolipase, which is activated in the intestinal lumen by trypsin. Its function is to prevent the inhibitory effect of bile salts on the lipase-catalyzed intraduodenal hydrolysis of dietary long-chain triglycerides.
Bile salt-dependent lipase, also known as carboxyl ester lipase is an enzyme produced by the adult pancreas and aids in the digestion of fats. Bile salt-stimulated lipase is an equivalent enzyme found within breast milk. BSDL has been found in the pancreatic secretions of all species in which it has been looked for. BSSL, originally discovered in the milk of humans and various other primates, has since been found in the milk of many animals including dogs, cats, rats, and rabbits.
PDX1, also known as insulin promoter factor 1, is a transcription factor in the ParaHox gene cluster. In vertebrates, Pdx1 is necessary for pancreatic development, including β-cell maturation, and duodenal differentiation. In humans this protein is encoded by the PDX1 gene, which was formerly known as IPF1. The gene was originally identified in the clawed frog Xenopus laevis and is present widely across the evolutionary diversity of bilaterian animals, although it has been lost in evolution in arthropods and nematodes. Despite the gene name being Pdx1, there is no Pdx2 gene in most animals; single-copy Pdx1 orthologs have been identified in all mammals. Coelacanth and cartilaginous fish are, so far, the only vertebrates shown to have two Pdx genes, Pdx1 and Pdx2.
Somatostatin receptor type 5 is a protein that in humans is encoded by the SSTR5 gene.
P2Y purinoceptor 4 is a protein that in humans is encoded by the P2RY4 gene.
Phospholipase A2, membrane associated is an enzyme that in humans is encoded by the PLA2G2A gene.
Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase is an enzyme that in humans is encoded by the GNE gene.
Pancreatic Stone Protein (PSP), also known as Lithostathine-1-alphaislet cells regeneration factor (ICRF) or islet of Langerhans regenerating protein (REG) is a protein that in humans is encoded by the REG1A gene as a single polypeptide of 144 amino acids further cleaved by trypsin to produce a 133 amino acid protein that is O-linked glycosylated on threonine 27. This protein is a type I subclass member of the Regenerating protein family. The Reg protein family is a multi protein family grouped into four subclasses, types I, II, III and IV based on the primary structures of the proteins. Reg family members REG1B, REGL, PAP and this gene are tandemly clustered on chromosome 2p12 and may have arisen from the same ancestral gene by gene duplication. The PSP is mostly produced in Human by the acinar cells of the pancreas and is secreted in the duodenum by the same pathway that pancreatic exocrine enzymes. It has C-terminal C-type lectin domain whose binding partner is currently unknown.
Calcium-dependent phospholipase A2 is an enzyme that in humans is encoded by the PLA2G5 gene.
Lithostathine-1-beta is a protein that in humans is encoded by the REG1B gene.
Glutathione S-transferase Mu 2 is an enzyme that in humans is encoded by the GSTM2 gene.
Cytosolic phospholipase A2 gamma is an enzyme that in humans is encoded by the PLA2G4C gene.
Pancreatic secretory granule membrane major glycoprotein GP2 is a protein that in humans is encoded by the GP2 gene.
Group 10 secretory phospholipase A2 is an enzyme that in humans is encoded by the PLA2G10 gene.
Group IID secretory phospholipase A2 is an enzyme that in humans is encoded by the PLA2G2D gene.
Phospholipase A-2-activating protein is an enzyme that in humans is encoded by the PLAA gene.
LYPLA3, also known as Group XV phospholipase A2, is an enzyme that in humans is encoded by the PLA2G15 gene.
Phospholipase A2, group IVB (cytosolic), also known as PLA2G4B, is a human gene.
Group XIIA secretory phospholipase A2 is an enzyme that in humans is encoded by the PLA2G12A gene.
Chymotrypsin C, also known as caldecrin or elastase 4, is an enzyme that in humans is encoded by the CTRC gene.
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