PLA2G2D

PLA2G2D
Identifiers
Aliases	PLA2G2D , PLA2IID, SPLASH, sPLA2-IID, sPLA2S, phospholipase A2 group IID
External IDs	OMIM: 605630 MGI: 1341796 HomoloGene: 7892 GeneCards: PLA2G2D
Gene location (Human)
Chr.	Chromosome 1 (human)
End	20,119,566 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	138,509,357 bp
RNA expression pattern
	Top expressed in
	lymph node; ; appendix; ; bone marrow cells; ; rectum; ; spleen; ; gallbladder; ; thymus; ; pharynx; ; thymus; ; superior surface of tongue;
	Top expressed in
	spleen; ; interventricular septum; ; thymus; ; sciatic nerve; ; subcutaneous adipose tissue; ; white adipose tissue; ; lip; ; upper arm; ; mammary gland; ; Paneth cell;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium ion binding ; phospholipase A2 activity ; heparin binding ; metal ion binding ; heparan sulfate proteoglycan binding ; hydrolase activity ; phospholipid binding ; calcium-dependent phospholipase A2 activity ;
Cellular component	extracellular region ;
Biological process	phosphatidic acid biosynthetic process ; phosphatidylserine acyl-chain remodeling ; phosphatidylethanolamine acyl-chain remodeling ; CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation ; lipid metabolism ; phosphatidylinositol acyl-chain remodeling ; lipid catabolic process ; negative regulation of T cell proliferation ; phosphatidylglycerol acyl-chain remodeling ; inflammatory response ; negative regulation of T cell activation ; phosphatidylcholine acyl-chain remodeling ; phospholipid metabolic process ; arachidonic acid secretion ;
	Sources:Amigo / QuickGO
Orthologs
	26279
	18782
	ENSG00000117215
	ENSMUSG00000041202
	Q9UNK4
	Q9WVF6
	NM_012400 ; NM_001271814
	NM_011109 ; NM_001347230
	NP_001258743 ; NP_036532
	NP_001334159 ; NP_035239
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 12, 2022

Group IID secretory phospholipase A2 is an enzyme that in humans is encoded by the PLA2G2D gene.^[5]^[6]

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000117215 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000041202 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Ishizaki J, Suzuki N, Higashino K, Yokota Y, Ono T, Kawamoto K, Fujii N, Arita H, Hanasaki K (Sep 1999). "Cloning and characterization of novel mouse and human secretory phospholipase A(2)s". J Biol Chem. 274 (35): 24973–9. doi: 10.1074/jbc.274.35.24973 . PMID 10455175.
↑ "Entrez Gene: PLA2G2D phospholipase A2, group IID".

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Leslie CC (2004). "Regulation of arachidonic acid availability for eicosanoid production". Biochem. Cell Biol. 82 (1): 1–17. doi:10.1139/o03-080. PMID 15052324.
Mavoungou E, Georges-Courbot MC, Poaty-Mavoungou V, et al. (1997). "HIV and SIV envelope glycoproteins induce phospholipase A2 activation in human and macaque lymphocytes". J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 16 (1): 1–9. doi:10.1097/00042560-199709010-00001. PMID 9377118.
Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948 . PMID 11076863.
Shakhov AN, Rubtsov AV, Lyakhov IG, et al. (2001). "SPLASH (PLA2IID), a novel member of phospholipase A2 family, is associated with lymphotoxin deficiency". Genes Immun. 1 (3): 191–9. doi: 10.1038/sj.gene.6363659 . PMID 11196711.
Lindbom J, Ljungman AG, Lindahl M, Tagesson C (2003). "Increased gene expression of novel cytosolic and secretory phospholipase A(2) types in human airway epithelial cells induced by tumor necrosis factor-alpha and IFN-gamma". J. Interferon Cytokine Res. 22 (9): 947–55. doi:10.1089/10799900260286650. PMID 12396716.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697 . PMID 12975309.
Eckey R, Menschikowski M, Lattke P, Jaross W (2005). "Increased hepatic cholesterol accumulation in transgenic mice overexpressing human secretory phospholipase A2 group IIA". Inflammation. 28 (2): 59–65. doi:10.1023/B:IFLA.0000033021.44105.9c. PMID 15379211. S2CID 21189952.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930 . PMID 15489336.
Takabatake N, Sata M, Inoue S, et al. (2006). "A novel polymorphism in secretory phospholipase A2-IID is associated with body weight loss in chronic obstructive pulmonary disease". Am. J. Respir. Crit. Care Med. 172 (9): 1097–104. doi:10.1164/rccm.200503-319OC. PMID 16002569.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501 . PMID 16381901.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi: 10.1038/nature04727 . PMID 16710414.
Lindbom J, Ljungman AG, Tagesson C (2007). "Interferon gamma-induced gene expression of the novel secretory phospholipase A2 type IID in human monocyte-derived macrophages is inhibited by lipopolysaccharide". Inflammation. 29 (2–3): 108–117. doi:10.1007/s10753-006-9007-x. PMID 16897354. S2CID 22943118.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000117215 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000041202 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10455175-5] Ishizaki J, Suzuki N, Higashino K, Yokota Y, Ono T, Kawamoto K, Fujii N, Arita H, Hanasaki K (Sep 1999). "Cloning and characterization of novel mouse and human secretory phospholipase A(2)s". J Biol Chem. 274 (35): 24973–9. doi: 10.1074/jbc.274.35.24973 . PMID 10455175.

[entrez-6] "Entrez Gene: PLA2G2D phospholipase A2, group IID".

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PLA2G2D

Related Research Articles

References

Further reading