POLR1A

POLR1A
Identifiers
Aliases	POLR1A , A190, RPA1, RPA194, RPO1-4, RPO14, AFDCIN, polymerase (RNA) I subunit A, RNA polymerase I subunit A, RPA190
External IDs	OMIM: 616404 MGI: 1096397 HomoloGene: 7033 GeneCards: POLR1A
Gene location (Human) Chr. Chromosome 2 (human) [1] Band 2p11.2 Start 86,020,216 bp [1] End 86,106,155 bp [1]
Gene location (Mouse) Chr. Chromosome 6 (mouse) [2] Band 6 C1|6 32.21 cM Start 71,886,037 bp [2] End 71,961,919 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve tibialis anterior muscle stromal cell of endometrium islet of Langerhans gastrocnemius muscle smooth muscle tissue ganglionic eminence bone marrow cells Achilles tendon left ventricle Top expressed in primitive streak yolk sac spermatocyte morula retinal pigment epithelium secondary oocyte internal carotid artery somite spermatid right ventricle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity DNA binding nucleotidyltransferase activity zinc ion binding metal ion binding DNA-directed 5'-3' RNA polymerase activity protein binding RNA polymerase I activity chromatin binding Cellular component nucleoplasm RNA polymerase I complex nucleus nucleolus Biological process termination of RNA polymerase I transcription epigenetic maintenance of chromatin in transcription-competent conformation transcription initiation from RNA polymerase I promoter transcription, DNA-templated negative regulation of protein localization to nucleolus transcription elongation from RNA polymerase I promoter Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 25885 20019 Ensembl ENSG00000068654 ENSMUSG00000049553 UniProt O95602 O35134 RefSeq (mRNA) NM_015425 NM_009088 RefSeq (protein) NP_056240 NP_033114 Location (UCSC) Chr 2: 86.02 – 86.11 Mb Chr 6: 71.89 – 71.96 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

DNA-directed RNA polymerase I subunit RPA1 is an enzyme that in humans is encoded by the POLR1A gene. ^{[5] [6]}

References

1. GRCh38: Ensembl release 89: ENSG00000068654 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000049553 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Seither P, Coy JF, Pouska A, Grummt I (Aug 1997). "Molecular cloning and characterization of the cDNA encoding the largest subunit of mouse RNA polymerase I". Mol Gen Genet. 255 (2): 180–6. doi:10.1007/s004380050487. PMID   9236775. S2CID   21286746.
6. "Entrez Gene: POLR1A polymerase (RNA) I polypeptide A, 194kDa".

Further reading

• Zhu L, Perlaky L, Henning D, Valdez BC (1998). "Cloning and characterization of a new silver-stainable protein SSP29, a member of the LRR family". Biochem. Mol. Biol. Int. 42 (5): 927–35. doi: 10.1080/15216549700203371 . PMID   9285060. S2CID   19749385.
• Chen HK, Pai CY, Huang JY, Yeh NH (2000). "Human Nopp140, which interacts with RNA polymerase I: implications for rRNA gene transcription and nucleolar structural organization". Mol. Cell. Biol. 19 (12): 8536–46. doi:10.1128/mcb.19.12.8536. PMC   84972 . PMID   10567578.
• Miller G, Panov KI, Friedrich JK, et al. (2001). "hRRN3 is essential in the SL1-mediated recruitment of RNA Polymerase I to rRNA gene promoters". EMBO J. 20 (6): 1373–82. doi:10.1093/emboj/20.6.1373. PMC   145519 . PMID   11250903.
• Yuan X, Zhao J, Zentgraf H, et al. (2003). "Multiple interactions between RNA polymerase I, TIF-IA and TAF(I) subunits regulate preinitiation complex assembly at the ribosomal gene promoter". EMBO Rep. 3 (11): 1082–7. doi:10.1093/embo-reports/kvf212. PMC   1307603 . PMID   12393749.
• Dundr M, Hoffmann-Rohrer U, Hu Q, et al. (2002). "A kinetic framework for a mammalian RNA polymerase in vivo". Science. 298 (5598): 1623–6. Bibcode:2002Sci...298.1623D. doi:10.1126/science.1076164. PMID   12446911. S2CID   36392120.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID   14743216. S2CID   11683986.
• Yamamoto K, Yamamoto M, Hanada K, et al. (2004). "Multiple protein-protein interactions by RNA polymerase I-associated factor PAF49 and role of PAF49 in rRNA transcription". Mol. Cell. Biol. 24 (14): 6338–49. doi:10.1128/MCB.24.14.6338-6349.2004. PMC   434256 . PMID   15226435.
• Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC   515316 . PMID   15342556.
• Percipalle P, Fomproix N, Cavellán E, et al. (2006). "The chromatin remodelling complex WSTF-SNF2h interacts with nuclear myosin 1 and has a role in RNA polymerase I transcription". EMBO Rep. 7 (5): 525–30. doi:10.1038/sj.embor.7400657. PMC   1479564 . PMID   16514417.