POLR1B

POLR1B
Identifiers
Aliases	POLR1B , RPA135, RPA2, Rpo1-2, polymerase (RNA) I subunit B, RNA polymerase I subunit B, A135, TCS4
External IDs	OMIM: 602000 MGI: 108014 HomoloGene: 7133 GeneCards: POLR1B
Gene location (Human) Chr. Chromosome 2 (human) [1] Band 2q14.1 Start 112,541,915 bp [1] End 112,579,818 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2|2 F1 Start 128,942,915 bp [2] End 128,968,514 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm endothelial cell superficial temporal artery nipple ventral tegmental area renal medulla cardia superior surface of tongue pylorus inferior ganglion of vagus nerve Top expressed in primitive streak morula yolk sac Paneth cell abdominal wall entorhinal cortex lip proximal tubule ureter somite More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity DNA binding nucleotidyltransferase activity ribonucleoside binding metal ion binding DNA-directed 5'-3' RNA polymerase activity protein binding RNA polymerase I activity Cellular component nucleoplasm nucleolus RNA polymerase I complex nucleus cytosol Biological process termination of RNA polymerase I transcription epigenetic maintenance of chromatin in transcription-competent conformation transcription initiation from RNA polymerase I promoter rRNA transcription transcription, DNA-templated embryo implantation nucleologenesis transcription elongation from RNA polymerase I promoter Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 84172 20017 Ensembl ENSG00000125630 ENSMUSG00000027395 UniProt Q9H9Y6 P70700 RefSeq (mRNA) NM_019014 NM_001137604 NM_001282772 NM_001282774 NM_001282776 NM_001282777 NM_001282779 NM_001371969 NM_001371970 NM_001371971 NM_009086 RefSeq (protein) NP_001131076 NP_001269701 NP_001269703 NP_001269705 NP_001269706 NP_001269708 NP_061887 NP_001358898 NP_001358899 NP_001358900 NP_033112 Location (UCSC) Chr 2: 112.54 – 112.58 Mb Chr 2: 128.94 – 128.97 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

DNA-directed RNA polymerase I subunit RPA2 is an enzyme that in humans is encoded by the POLR1B gene. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000125630 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027395 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: POLR1B polymerase (RNA) I polypeptide B, 128kDa".

Further reading

• Seither P, Zatsepina O, Hoffmann M, Grummt I (1997). "Constitutive and strong association of PAF53 with RNA polymerase I.". Chromosoma. 106 (4): 216–25. doi:10.1007/s004120050242. PMID   9254723. S2CID   23487728.
• Miller G, Panov KI, Friedrich JK (2001). "hRRN3 is essential in the SL1-mediated recruitment of RNA Polymerase I to rRNA gene promoters". EMBO J. 20 (6): 1373–82. doi:10.1093/emboj/20.6.1373. PMC   145519 . PMID   11250903.
• Seither P, Iben S, Thiry M, Grummt I (2002). "PAF67, a novel protein that is associated with the initiation-competent form of RNA polymerase I". Biol. Chem. 382 (8): 1163–70. doi:10.1515/BC.2001.146. PMID   11592397. S2CID   28819190.
• Shiau AK, Barstad D, Radek JT (2002). "Structural characterization of a subtype-selective ligand reveals a novel mode of estrogen receptor antagonism". Nat. Struct. Biol. 9 (5): 359–64. doi:10.1038/nsb787. PMID   11953755. S2CID   452305.
• Egea PF, Mitschler A, Moras D (2002). "Molecular recognition of agonist ligands by RXRs". Mol. Endocrinol. 16 (5): 987–97. doi: 10.1210/mend.16.5.0823 . PMID   11981034.
• Strausberg RL, Feingold EA, Grouse LH (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Bouwmeester T, Bauch A, Ruffner H (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID   14743216. S2CID   11683986.
• Yamamoto K, Yamamoto M, Hanada K (2004). "Multiple Protein-Protein Interactions by RNA Polymerase I-Associated Factor PAF49 and Role of PAF49 in rRNA Transcription". Mol. Cell. Biol. 24 (14): 6338–49. doi:10.1128/MCB.24.14.6338-6349.2004. PMC   434256 . PMID   15226435.
• Philimonenko VV, Zhao J, Iben S (2005). "Nuclear actin and myosin I are required for RNA polymerase I transcription". Nat. Cell Biol. 6 (12): 1165–72. doi:10.1038/ncb1190. PMID   15558034. S2CID   6633625.
• Hillier LW, Graves TA, Fulton RS (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi: 10.1038/nature03466 . PMID   15815621.
• Zhang C, Comai L, Johnson DL (2005). "PTEN Represses RNA Polymerase I Transcription by Disrupting the SL1 Complex". Mol. Cell. Biol. 25 (16): 6899–911. doi:10.1128/MCB.25.16.6899-6911.2005. PMC   1190253 . PMID   16055704.
• Percipalle P, Fomproix N, Cavellán E (2006). "The chromatin remodelling complex WSTF–SNF2h interacts with nuclear myosin 1 and has a role in RNA polymerase I transcription". EMBO Rep. 7 (5): 525–30. doi:10.1038/sj.embor.7400657. PMC   1479564 . PMID   16514417.
• Panova TB, Panov KI, Russell J, Zomerdijk JC (2006). "Casein Kinase 2 Associates with Initiation-Competent RNA Polymerase I and Has Multiple Roles in Ribosomal DNA Transcription". Mol. Cell. Biol. 26 (16): 5957–68. doi:10.1128/MCB.00673-06. PMC   1592790 . PMID   16880508.
• Johnson SS, Zhang C, Fromm J (2007). "Mammalian Maf1 is a negative regulator of transcription by all three nuclear RNA polymerases". Mol. Cell. 26 (3): 367–79. doi: 10.1016/j.molcel.2007.03.021 . PMID   17499043.