POP5

POP5
Identifiers
Aliases	POP5 , HSPC004, RPP2, RPP20, hPop5, POP5 homolog, ribonuclease P/MRP subunit
External IDs	OMIM: 609992; MGI: 2151221; HomoloGene: 41076; GeneCards: POP5; OMA:POP5 - orthologs
Gene location (Human) Chr. Chromosome 12 (human) [1] Band 12q24.31 Start 120,578,764 bp [1] End 120,581,402 bp [1]
Gene location (Mouse) Chr. Chromosome 5 (mouse) [2] Band 5|5 F Start 115,373,895 bp [2] End 115,383,410 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon right adrenal gland right adrenal cortex anterior pituitary left adrenal cortex right lobe of thyroid gland left lobe of thyroid gland right lobe of liver right uterine tube spleen Top expressed in dentate gyrus of hippocampal formation granule cell right kidney superior frontal gyrus embryo yolk sac primary visual cortex facial motor nucleus embryo proximal tubule human kidney More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ribonuclease activity protein binding hydrolase activity ribonuclease P activity Cellular component nucleolus nucleolar ribonuclease P complex nucleus nucleoplasm ribonuclease MRP complex multimeric ribonuclease P complex Biological process RNA metabolic process RNA phosphodiester bond hydrolysis RNA phosphodiester bond hydrolysis, endonucleolytic tRNA processing protein lipoylation tRNA 5'-leader removal rRNA processing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51367 117109 Ensembl ENSG00000167272 ENSMUSG00000060152 UniProt Q969H6 Q9DB28 RefSeq (mRNA) NM_015918 NM_198201 NM_198202 NM_026398 RefSeq (protein) NP_057002 NP_937845 NP_080674 NP_001390591 Location (UCSC) Chr 12: 120.58 – 120.58 Mb Chr 5: 115.37 – 115.38 Mb PubMed search [3] [4]
Wikidata
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Ribonuclease P/MRP protein subunit POP5 is an enzyme that in humans is encoded by the POP5 gene. ^{[5] [6]}

References

1. GRCh38: Ensembl release 89: ENSG00000167272 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000060152 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. van Eenennaam H, Lugtenberg D, Vogelzangs JH, van Venrooij WJ, Pruijn GJ (Aug 2001). "hPop5, a protein subunit of the human RNase MRP and RNase P endoribonucleases" (PDF). J Biol Chem. 276 (34): 31635–41. doi: 10.1074/jbc.M103399200 . PMID   11413139.
6. "Entrez Gene: POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae)".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• van Eenennaam H, Pruijn GJ, van Venrooij WJ (1999). "hPop4: a new protein subunit of the human RNase MRP and RNase P ribonucleoprotein complexes". Nucleic Acids Res. 27 (12): 2465–72. doi:10.1093/nar/27.12.2465. PMC   148449 . PMID   10352175.
• Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. Bibcode:2000PNAS...97.9543H. doi: 10.1073/pnas.160270997 . PMC   16901 . PMID   10931946.
• Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC   310934 . PMID   11042152.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Welting TJ, van Venrooij WJ, Pruijn GJ (2004). "Mutual interactions between subunits of the human RNase MRP ribonucleoprotein complex". Nucleic Acids Res. 32 (7): 2138–46. doi:10.1093/nar/gkh539. PMC   407822 . PMID   15096576.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.