PPIH

Last updated
PPIH
Protein PPIH PDB 1mzw.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases PPIH , CYP-20, CYPH, SnuCyp-20, USA-CYP, peptidylprolyl isomerase H
External IDs OMIM: 606095; MGI: 106499; HomoloGene: 38172; GeneCards: PPIH; OMA:PPIH - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006347
NM_001330510

NM_001110129
NM_001110130
NM_028677

RefSeq (protein)

NP_001317439
NP_006338

NP_001103599
NP_001103600
NP_082953

Location (UCSC) Chr 1: 42.66 – 42.68 Mb Chr 4: 119.16 – 119.18 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Peptidyl-prolyl cis-trans isomerase H is an enzyme that in humans is encoded by the PPIH gene. [5] [6] [7]

The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein is a specific component of the complex that includes pre-mRNA processing factors PRPF3, PRPF4, and PRPF18, as well as U4/U5/U6 tri-snRNP. This protein has been shown to possess PPIase activity and may act as a protein chaperone that mediates the interactions between different proteins inside the spliceosome. [7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000171960 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000060288 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Horowitz DS, Kobayashi R, Krainer AR (Dec 1997). "A new cyclophilin and the human homologues of yeast Prp3 and Prp4 form a complex associated with U4/U6 snRNPs". RNA. 3 (12): 1374–87. PMC   1369579 . PMID   9404889.
  6. Teigelkamp S, Achsel T, Mundt C, Gothel SF, Cronshagen U, Lane WS, Marahiel M, Luhrmann R (May 1998). "The 20kD protein of human U4/U6.U5 tri-snRNPs is a novel cyclophilin that forms a complex with the U4/U6-specific 60kD and 90kD proteins". RNA. 4 (2): 127–41. PMC   1369602 . PMID   9570313.
  7. 1 2 "Entrez Gene: PPIH peptidylprolyl isomerase H (cyclophilin H)".

Further reading