PPIL3

PPIL3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1XYH, 2OJU, 2OK3
Identifiers
Aliases	PPIL3 , CYPJ, peptidylprolyl isomerase like 3
External IDs	OMIM: 615811 MGI: 1917475 HomoloGene: 41717 GeneCards: PPIL3
Gene location (Human)
Chr.	Chromosome 2 (human)
End	200,889,303 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	58,484,645 bp
RNA expression pattern
	Top expressed in
	pancreatic epithelial cell; ; ganglionic eminence; ; secondary oocyte; ; right uterine tube; ; tibialis anterior muscle; ; germinal epithelium; ; tibia; ; lymph node; ; monocyte; ; appendix;
	Top expressed in
	facial motor nucleus; ; hand; ; primitive streak; ; otolith organ; ; utricle; ; superior cervical ganglion; ; medullary collecting duct; ; condyle; ; endocardial cushion; ; blood;
	More reference expression data
	n/a
Gene ontology
Molecular function	isomerase activity ; protein binding ; peptidyl-prolyl cis-trans isomerase activity ;
Cellular component	catalytic step 2 spliceosome ; spliceosomal complex ;
Biological process	mRNA splicing, via spliceosome ; mRNA processing ; protein folding ; RNA splicing ; protein peptidyl-prolyl isomerization ;
	Sources:Amigo / QuickGO
Orthologs
	53938
	70225
	ENSG00000240344
	ENSMUSG00000026035
	Q9H2H8
	Q9D6L8
	NM_032472 ; NM_130906 ; NM_131916
	NM_001285826 ; NM_001285827 ; NM_027351 ; NM_027374
	NP_115861 ; NP_570981
	NP_001272755 ; NP_001272756 ; NP_081627 ; NP_081650
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated November 29, 2023

Peptidyl-prolyl cis-trans isomerase-like 3 is an enzyme that in humans is encoded by the PPIL3 gene.^[5]^[6]

Function

This gene encodes a member of the cyclophilin family. Cyclophilins catalyze the cis-trans isomerization of peptidylprolyl imide bonds in oligopeptides. They have been proposed to act either as catalysts or as molecular chaperones in protein-folding events. Transcript variants derived from alternative splicing and/or alternative polyadenylation exist; some of these variants encode different isoforms.^[6]

Related Research Articles

Peptidylprolyl isomerase A (PPIA), also known as cyclophilin A (CypA) or rotamase A is an enzyme that in humans is encoded by the PPIA gene on chromosome 7. As a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family, this protein catalyzes the cis-trans isomerization of proline imidic peptide bonds, which allows it to regulate many biological processes, including intracellular signaling, transcription, inflammation, and apoptosis. Due to its various functions, PPIA has been implicated in a broad range of inflammatory diseases, including atherosclerosis and arthritis, and viral infections.

Peptidyl-prolyl cis-trans isomerase B is an enzyme that is encoded by the PPIB gene. As a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family, this protein catalyzes the cis-trans isomerization of proline imidic peptide bonds, which allows it to regulate protein folding of type I collagen. Generally, PPIases are found in all eubacteria and eukaryotes, as well as in a few archaebacteria, and thus are highly conserved.

FK506-binding protein 3 also known as FKBP25 is a protein that in humans is encoded by the FKBP3 gene.

Peptidylprolyl isomerase D (cyclophilin D), also known as PPID, is an enzyme which in humans is encoded by the PPID gene on chromosome 4. As a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family, this protein catalyzes the cis-trans isomerization of proline imidic peptide bonds, which allows it to facilitate folding or repair of proteins. In addition, PPID participates in many biological processes, including mitochondrial metabolism, apoptosis, redox, and inflammation, as well as in related diseases and conditions, such as ischemic reperfusion injury, AIDS, and cancer.

Type-1 angiotensin II receptor-associated protein is a protein that in humans is encoded by the AGTRAP gene.

Peptidyl-prolyl cis-trans isomerase, mitochondrial (PPIF) is an enzyme that in humans is encoded by the PPIF gene. It has also been referred to as, but should not be confused with, cyclophilin D (CypD), which is encoded by the PPID gene. As a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family, this protein catalyzes the cis-trans isomerization of proline imidic peptide bonds, which allows it to facilitate folding or repair of proteins. PPIF is a major component of the mitochondrial permeability transition pore (MPTP) and, thus, highly involved in mitochondrial metabolism and apoptosis, as well as in mitochondrial diseases and related conditions, including cardiac diseases, neurodegenerative diseases, and muscular dystrophy. In addition, PPIF participates in inflammation, as well as in ischemic reperfusion injury, AIDS, and cancer.

Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 is an enzyme that in humans is encoded by the PIN4 gene.

Peptidyl-prolyl cis-trans isomerase-like 1 is an enzyme that in humans is encoded by the PPIL1 gene.

Peptidyl-prolyl cis-trans isomerase H is an enzyme that in humans is encoded by the PPIH gene.

Dehydrogenase/reductase SDR family member 1, also known as Short chain dehydrogenase/reductase family 19C member 1 is an enzyme that in humans is encoded by the DHRS1 gene located on chromosome 14.

Peptidyl-prolyl cis-trans isomerase C (PPIC) is an enzyme that in humans is encoded by the PPIC gene on chromosome 5. As a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family, this protein catalyzes the cis-trans isomerization of proline imidic peptide bonds, which allows it to facilitate folding or repair of proteins. In addition, PPIC participates in many biological processes, including mitochondrial metabolism, apoptosis, redox, and inflammation, as well as in related diseases and conditions, such as ischemic reperfusion injury, AIDS, and cancer.

Peptidyl-prolyl cis-trans isomerase G is an enzyme that in humans is encoded by the PPIG gene.

Peptidylprolyl isomerase E (cyclophilin E), also known as PPIE, is an enzyme which in humans is encoded by the PPIE gene on chromosome 1. As a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family, this protein catalyzes the cis-trans isomerization of proline imidic peptide bonds, which allows it to facilitate folding or repair of proteins. In addition, PPIE participates in many biological processes, including mitochondrial metabolism, apoptosis, and inflammation, as well as related diseases and conditions, such as ischemic reperfusion injury, AIDS, influenza, and cancer.

Putative hydrolase RBBP9 is an enzyme that in humans is encoded by the RBBP9 gene.

Peptidyl-prolyl cis-trans isomerase-like 2 is an enzyme that in humans is encoded by the PPIL2 gene.

LETM1 domain-containing protein 1 is a protein that in humans is encoded by the LETMD1 gene.

Peptidyl-prolyl cis-trans isomerase-like 4 is an enzyme that in humans is encoded by the PPIL4 gene.

Dual specificity protein phosphatase 18 is an enzyme that is encoded by the DUSP18 gene in humans.

Transcription factor AP-2 delta , also known as TFAP2D, is a human gene. The protein encoded by this gene is a transcription factor.

Tektin-1 is a protein that in humans is encoded by the TEKT1 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000240344 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026035 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Zhou Z, Ying K, Dai J, Tang R, Wang W, Huang Y, Zhao W, Xie Y, Mao Y (Jul 2001). "Molecular cloning and characterization of a novel peptidylprolyl isomerase (cyclophilin)-like gene (PPIL3) from human fetal brain". Cytogenetics and Cell Genetics. 92 (3–4): 231–6. doi:10.1159/000056909. PMID 11435694. S2CID 713529.
1 2 "Entrez Gene: PPIL3 peptidylprolyl isomerase (cyclophilin)-like 3".

PPIL3

Contents

Function

Related Research Articles

References

Further reading