PPM1F

PPM1F
Identifiers
Aliases	PPM1F , CAMKP, CaMKPase, FEM-2, POPX2, hFEM-2, protein phosphatase, Mg2+/Mn2+ dependent 1F
External IDs	MGI: 1918464 HomoloGene: 22828 GeneCards: PPM1F
Gene location (Human) Chr. Chromosome 22 (human) [1] Band 22q11.22 Start 21,919,425 bp [1] End 21,952,848 bp [1]
Gene location (Mouse) Chr. Chromosome 16 (mouse) [2] Band 16|16 A3 Start 16,714,333 bp [2] End 16,745,228 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte sural nerve blood endothelial cell periodontal fiber spleen right lung tibia upper lobe of left lung stromal cell of endometrium Top expressed in hand right lung lobe carotid body otolith organ lens utricle external carotid artery substantia nigra internal carotid artery interventricular septum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phosphoprotein phosphatase activity calmodulin-dependent protein phosphatase activity metal ion binding protein binding catalytic activity cation binding hydrolase activity protein serine/threonine phosphatase activity protein tyrosine/serine/threonine phosphatase activity Cellular component perinuclear region of cytoplasm cytosol protein-containing complex Biological process apoptotic process peptidyl-threonine dephosphorylation negative regulation of protein kinase activity protein dephosphorylation positive regulation of epithelial cell migration positive regulation of growth intrinsic apoptotic signaling pathway positive regulation of gene expression positive regulation of chemotaxis negative regulation of protein kinase activity by regulation of protein phosphorylation negative regulation of peptidyl-serine phosphorylation positive regulation of focal adhesion assembly negative regulation of transcription, DNA-templated positive regulation of stress fiber assembly positive regulation of cell-substrate adhesion positive regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of cell migration negative regulation of protein transport peptidyl-serine dephosphorylation negative regulation of cell-cell adhesion mediated by cadherin Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9647 68606 Ensembl ENSG00000100034 ENSMUSG00000026181 UniProt P49593 Q8CGA0 RefSeq (mRNA) NM_014634 NM_176833 RefSeq (protein) NP_055449 NP_789803 Location (UCSC) Chr 22: 21.92 – 21.95 Mb Chr 16: 16.71 – 16.75 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Protein phosphatase 1F is an enzyme that in humans is encoded by the PPM1F gene. ^{[5] [6] [7]}

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase can interact with Rho guanine nucleotide exchange factors (PIX), and thus block the effects of p21-activated kinase 1 (PAK), a protein kinase mediating biological effects downstream of Rho GTPases. Calcium/calmodulin-dependent protein kinase II gamma (CAMK2G/CAMK-II) is found to be one of the substrates of this phosphatase. The overexpression of this phosphatase or CAMK2G has been shown to mediate caspase-dependent apoptosis. An alternatively spliced transcript variant has been identified, but its full-length nature has not been determined. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000100034 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026181 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Koh CG, Tan EJ, Manser E, et al. (Feb 2002). "The p21-activated kinase PAK is negatively regulated by POPX1 and POPX2, a pair of serine/threonine phosphatases of the PP2C family". Curr Biol. 12 (4): 317–21. Bibcode:2002CBio...12..317K. doi: 10.1016/S0960-9822(02)00652-8 . PMID   11864573.
6. Tan KM, Chan SL, Tan KO, et al. (Nov 2001). "The Caenorhabditis elegans sex-determining protein FEM-2 and its human homologue, hFEM-2, are Ca2+/calmodulin-dependent protein kinase phosphatases that promote apoptosis". J Biol Chem. 276 (47): 44193–202. doi: 10.1074/jbc.M105880200 . PMID   11559703.
7. "Entrez Gene: PPM1F protein phosphatase 1F (PP2C domain containing)".

Further reading

• Nomura N, Miyajima N, Sazuka T, et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1". DNA Res. 1 (1): 27–35. doi: 10.1093/dnares/1.1.27 . PMID   7584026.
• Nomura N, Miyajima N, Sazuka T, et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement)". DNA Res. 1 (1): 47–56. doi: 10.1093/dnares/1.1.47 . PMID   7584028.
• Kawasaki K, Minoshima S, Nakato E, et al. (1997). "One-megabase sequence analysis of the human immunoglobulin lambda gene locus". Genome Res. 7 (3): 250–61. doi: 10.1101/gr.7.3.250 . PMID   9074928.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Izmailova E, Bertley FM, Huang Q, et al. (2003). "HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages". Nat. Med. 9 (2): 191–7. doi:10.1038/nm822. PMID   12539042. S2CID   26145639.
• Harvey BP, Banga SS, Ozer HL (2004). "Regulation of the multifunctional Ca2+/calmodulin-dependent protein kinase II by the PP2C phosphatase PPM1F in fibroblasts". J. Biol. Chem. 279 (23): 24889–98. doi: 10.1074/jbc.M400656200 . PMID   15140879.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.