PPM1G

PPM1G
Identifiers
Aliases	PPM1G , PP2CG, PP2CGAMMA, PPP2CG, protein phosphatase, Mg2+/Mn2+ dependent 1G
External IDs	OMIM: 605119 MGI: 106065 HomoloGene: 31106 GeneCards: PPM1G
Gene location (Human) Chr. Chromosome 2 (human) [1] Band 2p23.3 Start 27,381,195 bp [1] End 27,409,591 bp [1]
Gene location (Mouse) Chr. Chromosome 5 (mouse) [2] Band 5 B1|5 17.27 cM Start 31,360,008 bp [2] End 31,378,031 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence sperm islet of Langerhans gastrocnemius muscle stromal cell of endometrium rectum body of stomach Left adrenal gland anterior pituitary Right adrenal gland Top expressed in spermatid ectoderm otic placode seminiferous tubule spermatocyte primitive streak saccule somite neural tube bone marrow More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein serine/threonine phosphatase activity protein binding catalytic activity phosphoprotein phosphatase activity hydrolase activity metal ion binding cation binding Cellular component cytoplasm membrane nucleus nucleoplasm Biological process protein dephosphorylation peptidyl-threonine dephosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5496 14208 Ensembl ENSG00000115241 ENSMUSG00000029147 UniProt O15355 Q6IAU5 Q61074 RefSeq (mRNA) NM_177983 NM_008014 RefSeq (protein) NP_817092 NP_817092.1 NP_032040 Location (UCSC) Chr 2: 27.38 – 27.41 Mb Chr 5: 31.36 – 31.38 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Protein phosphatase 1G is an enzyme that in humans is encoded by the PPM1G gene. ^{[5] [6]}

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase is found to be responsible for the dephosphorylation of Pre-mRNA splicing factors, which is important for the formation of functional spliceosome. Studies of a similar gene in mice suggested a role of this phosphatase in regulating cell cycle progression. Alternatively spliced transcript variants encoding the same protein have been described. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000115241 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000029147 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Travis SM, Welsh MJ (Sep 1997). "PP2C gamma: a human protein phosphatase with a unique acidic domain". FEBS Lett. 412 (3): 415–9. doi: 10.1016/S0014-5793(97)00837-5 . PMID   9276438. S2CID   82436336.
6. "Entrez Gene: PPM1G protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform".

Further reading

• Guthridge MA, Bellosta P, Tavoloni N, Basilico C (1997). "FIN13, a novel growth factor-inducible serine-threonine phosphatase which can inhibit cell cycle progression". Mol. Cell. Biol. 17 (9): 5485–98. doi:10.1128/mcb.17.9.5485. PMC   232397 . PMID   9271424.
• Murray MV, Kobayashi R, Krainer AR (1999). "The type 2C Ser/Thr phosphatase PP2Cgamma is a pre-mRNA splicing factor". Genes Dev. 13 (1): 87–97. doi:10.1101/gad.13.1.87. PMC   316367 . PMID   9887102.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Flajolet M, Rakhilin S, Wang H, et al. (2004). "Protein phosphatase 2C binds selectively to and dephosphorylates metabotropic glutamate receptor 3". Proc. Natl. Acad. Sci. U.S.A. 100 (26): 16006–11. doi: 10.1073/pnas.2136600100 . PMC   307683 . PMID   14663150.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Maynes JT, Luu HA, Cherney MM, et al. (2006). "Crystal structures of protein phosphatase-1 bound to motuporin and dihydromicrocystin-LA: elucidation of the mechanism of enzyme inhibition by cyanobacterial toxins". J. Mol. Biol. 356 (1): 111–20. doi:10.1016/j.jmb.2005.11.019. PMID   16343532.
• Suh EJ, Kim TY, Kim SH (2007). "PP2Cgamma-mediated S-phase accumulation induced by the proteasome-dependent degradation of p21(WAF1/CIP1)". FEBS Lett. 580 (26): 6100–4. doi:10.1016/j.febslet.2006.10.005. PMID   17054950. S2CID   81205783.
• Kimura H, Takizawa N, Allemand E, et al. (2006). "A novel histone exchange factor, protein phosphatase 2Cgamma, mediates the exchange and dephosphorylation of H2A-H2B". J. Cell Biol. 175 (3): 389–400. doi:10.1083/jcb.200608001. PMC   2064517 . PMID   17074886.
• Luo W, Peterson A, Garcia BA, et al. (2007). "Protein phosphatase 1 regulates assembly and function of the beta-catenin degradation complex". EMBO J. 26 (6): 1511–21. doi:10.1038/sj.emboj.7601607. PMC   1829374 . PMID   17318175.
• Allemand E, Hastings ML, Murray MV, et al. (2007). "Alternative splicing regulation by interaction of phosphatase PP2Cgamma with nucleic acid-binding protein YB-1". Nat. Struct. Mol. Biol. 14 (7): 630–8. doi:10.1038/nsmb1257. PMID   17572683. S2CID   3187530.
• Petri S, Grimmler M, Over S, et al. (2007). "Dephosphorylation of survival motor neurons (SMN) by PPM1G/PP2Cgamma governs Cajal body localization and stability of the SMN complex". J. Cell Biol. 179 (3): 451–65. doi:10.1083/jcb.200704163. PMC   2064792 . PMID   17984321.