PPM1K

PPM1K
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2IQ1, 4DA1
Identifiers
Aliases	PPM1K , BDP, MSUDMV, PP2Ckappa, PP2Cm, PTMP, UG0882E07, protein phosphatase, Mg2+/Mn2+ dependent 1K
External IDs	OMIM: 611065 MGI: 2442111 HomoloGene: 36819 GeneCards: PPM1K
Gene location (Human) Chr. Chromosome 4 (human) [1] Band 4q22.1 Start 88,257,620 bp [1] End 88,284,769 bp [1]
Gene location (Mouse) Chr. Chromosome 6 (mouse) [2] Band 6|6 B3 Start 57,506,502 bp [2] End 57,535,468 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right ventricle postcentral gyrus middle temporal gyrus internal globus pallidus superior frontal gyrus palpebral conjunctiva pons Brodmann area 46 endothelial cell tibialis anterior muscle Top expressed in piriform cortex interventricular septum medial geniculate nucleus left lobe of liver Region I of hippocampus proper globus pallidus myocardium of ventricle inferior colliculus lateral geniculate nucleus parotid gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein serine/threonine phosphatase activity protein binding catalytic activity phosphoprotein phosphatase activity hydrolase activity metal ion binding cation binding Cellular component mitochondrial matrix mitochondrion Biological process protein dephosphorylation branched-chain amino acid catabolic process positive regulation of pyruvate dehydrogenase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 152926 243382 Ensembl ENSG00000163644 ENSMUSG00000037826 UniProt Q8N3J5 Q8BXN7 RefSeq (mRNA) NM_152542 NM_175523 RefSeq (protein) NP_689755 NP_780732 Location (UCSC) Chr 4: 88.26 – 88.28 Mb Chr 6: 57.51 – 57.54 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Protein phosphatase 1K, mitochondrial is an enzyme that in humans is encoded by the PPM1K gene. ^{[5] [6]}

References

1. GRCh38: Ensembl release 89: ENSG00000163644 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000037826 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA (Dec 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc Natl Acad Sci U S A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
6. "Entrez Gene: PPM1K protein phosphatase 1K (PP2C domain containing)".

Further reading

• Lu G, Ren S, Korge P, et al. (2007). "A novel mitochondrial matrix serine/threonine protein phosphatase regulates the mitochondria permeability transition pore and is essential for cellular survival and development". Genes Dev. 21 (7): 784–96. doi:10.1101/gad.1499107. PMC   1838530 . PMID   17374715.
• Joshi M, Jeoung NH, Popov KM, Harris RA (2007). "Identification of a novel PP2C-type mitochondrial phosphatase". Biochem. Biophys. Res. Commun. 356 (1): 38–44. doi:10.1016/j.bbrc.2007.02.108. PMC   1876681 . PMID   17336929.
• Dai J, Zhang J, Sun Y, et al. (2006). "Characterization of a novel human protein phosphatase 2C family member, PP2Ckappa". Int. J. Mol. Med. 17 (6): 1117–23. doi: 10.3892/ijmm.17.6.1117 . PMID   16685424.
• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi: 10.1038/nature03466 . PMID   15815621.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Sanger Centre, The; Washington University Genome Sequencing Cente, The (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi: 10.1101/gr.8.11.1097 . PMID   9847074.