PPP1R14B

PPP1R14B
Identifiers
Aliases	PPP1R14B , PHI-1, PLCB3N, PNG, SOM172, protein phosphatase 1 regulatory inhibitor subunit 14B
External IDs	OMIM: 601140 MGI: 107682 HomoloGene: 7483 GeneCards: PPP1R14B
Gene location (Human)
Chr.	Chromosome 11 (human)
End	64,246,943 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	6,954,692 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; body of pancreas; ; right coronary artery; ; stromal cell of endometrium; ; skin of abdomen; ; gastrocnemius muscle; ; skeletal muscle tissue; ; left coronary artery; ; ascending aorta; ; renal cortex;
	Top expressed in
	lip; ; esophagus; ; yolk sac; ; nucleus pulposus; ; spermatid; ; morula; ; spermatocyte; ; superior frontal gyrus; ; neural tube; ; mirror;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein phosphatase inhibitor activity ; phosphatase inhibitor activity ; protein phosphatase regulator activity ; protein serine/threonine phosphatase inhibitor activity ;
Cellular component	cytoplasm ;
Biological process	regulation of phosphorylation ; innate immune response ; negative regulation of phosphoprotein phosphatase activity ; negative regulation of catalytic activity ; regulation of phosphoprotein phosphatase activity ;
	Sources:Amigo / QuickGO
Orthologs
	26472
	18938
	ENSG00000173457
	ENSMUSG00000056612
	Q96C90
	Q62084
	NM_138689
	NM_008889
	NP_619634
	NP_032915
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated December 03, 2023

Protein phosphatase 1 regulatory subunit 14B is an enzyme that in humans is encoded by the PPP1R14B gene.^[5]^[6]^[7]

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000173457 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000056612 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Lagercrantz J, Carson E, Larsson C, Nordenskjold M, Weber G (Mar 1997). "Isolation and characterization of a novel gene close to the human phosphoinositide-specific phospholipase C beta 3 gene on chromosomal region 11q13". Genomics. 31 (3): 380–4. doi:10.1006/geno.1996.0063. PMID 8838322.
↑ Eto M, Karginov A, Brautigan DL (Jan 2000). "A novel phosphoprotein inhibitor of protein type-1 phosphatase holoenzymes". Biochemistry. 38 (51): 16952–7. doi:10.1021/bi992030o. PMID 10606530.
↑ "Entrez Gene: PPP1R14B protein phosphatase 1, regulatory (inhibitor) subunit 14B".

Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi: 10.1073/pnas.97.7.3491 . PMC 16267 . PMID 10737800.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Tountas NA, Mandell JW, Everett AD, Brautigan DL (2005). "Juxtamembrane localization of the protein phosphatase-1 inhibitor protein PHI-1 in smooth muscle cells". Histochem. Cell Biol. 121 (4): 343–50. doi:10.1007/s00418-004-0642-8. PMID 15083373. S2CID 21262452.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Tountas NA, Brautigan DL (2005). "Migration and retraction of endothelial and epithelial cells require PHI-1, a specific protein-phosphatase-1 inhibitor protein". J. Cell Sci. 117 (Pt 24): 5905–12. doi:10.1242/jcs.01506. PMID 15522888.
Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674. S2CID 69278.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000173457 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000056612 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8838322-5] Lagercrantz J, Carson E, Larsson C, Nordenskjold M, Weber G (Mar 1997). "Isolation and characterization of a novel gene close to the human phosphoinositide-specific phospholipase C beta 3 gene on chromosomal region 11q13". Genomics. 31 (3): 380–4. doi:10.1006/geno.1996.0063. PMID 8838322.

[pmid10606530-6] Eto M, Karginov A, Brautigan DL (Jan 2000). "A novel phosphoprotein inhibitor of protein type-1 phosphatase holoenzymes". Biochemistry. 38 (51): 16952–7. doi:10.1021/bi992030o. PMID 10606530.

[entrez-7] "Entrez Gene: PPP1R14B protein phosphatase 1, regulatory (inhibitor) subunit 14B".

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PPP1R14B

Related Research Articles

References

Further reading