PPP1R7

PPP1R7
Identifiers
Aliases	PPP1R7 , SDS22, protein phosphatase 1 regulatory subunit 7
External IDs	OMIM: 602877; MGI: 1913635; HomoloGene: 2032; GeneCards: PPP1R7; OMA:PPP1R7 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) [1] Band 2q37.3 Start 241,149,576 bp [1] End 241,183,652 bp [1]
Gene location (Mouse) Chr. Chromosome 1 (mouse) [2] Band 1|1 D Start 93,270,576 bp [2] End 93,301,211 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right testis left testis nucleus accumbens caudate nucleus putamen olfactory zone of nasal mucosa sperm right frontal lobe right uterine tube prefrontal cortex Top expressed in tail of embryo dorsal striatum olfactory tubercle nucleus accumbens genital tubercle cingulate gyrus seminiferous tubule primitive streak Region I of hippocampus proper dentate gyrus of hippocampal formation granule cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function enzyme regulator activity protein binding protein phosphatase regulator activity Cellular component cytoplasm extracellular exosome nucleus chromosome Biological process positive regulation of protein dephosphorylation chromosome segregation regulation of catalytic activity regulation of phosphoprotein phosphatase activity calcium activated phospholipid scrambling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5510 66385 Ensembl ENSG00000115685 ENSMUSG00000026275 UniProt Q15435 Q3UM45 RefSeq (mRNA) NM_001282409 NM_001282410 NM_001282411 NM_001282412 NM_001282413 NM_001282414 NM_002712 NM_023200 RefSeq (protein) NP_001269338 NP_001269339 NP_001269340 NP_001269341 NP_001269342 NP_001269343 NP_002703 NP_075689 Location (UCSC) Chr 2: 241.15 – 241.18 Mb Chr 1: 93.27 – 93.3 Mb PubMed search [3] [4]
Wikidata
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Protein phosphatase 1 regulatory subunit 7 is an enzyme that in humans is encoded by the PPP1R7 gene. ^{[5] [6] [7] [8]}

References

1. GRCh38: Ensembl release 89: ENSG00000115685 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026275 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Renouf S, Beullens M, Wera S, Van Eynde A, Sikela J, Stalmans W, Bollen M (Jan 1996). "Molecular cloning of a human polypeptide related to yeast sds22, a regulator of protein phosphatase-1". FEBS Lett. 375 (1–2): 75–8. doi: 10.1016/0014-5793(95)01180-M . PMID   7498485. S2CID   41223011.
6. Berry R, Stevens TJ, Walter NA, Wilcox AS, Rubano T, Hopkins JA, Weber J, Goold R, Soares MB, Sikela JM (Oct 1995). "Gene-based sequence-tagged-sites (STSs) as the basis for a human gene map". Nat Genet. 10 (4): 415–23. doi:10.1038/ng0895-415. PMID   7670491. S2CID   22277955.
7. Ceulemans H, Van Eynde A, Perez-Callejon E, Beullens M, Stalmans W, Bollen M (Jun 1999). "Structure and splice products of the human gene encoding sds22, a putative mitotic regulator of protein phosphatase-1". Eur J Biochem. 262 (1): 36–42. doi: 10.1046/j.1432-1327.1999.00344.x . PMID   10231361.
8. "Entrez Gene: PPP1R7 protein phosphatase 1, regulatory (inhibitor) subunit 7".

Further reading

• Lesage B, Beullens M, Pedelini L, et al. (2007). "A complex of catalytically inactive protein phosphatase-1 sandwiched between Sds22 and inhibitor-3". Biochemistry. 46 (31): 8909–19. doi:10.1021/bi7003119. PMID   17630778.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ceulemans H, Vulsteke V, De Maeyer M, et al. (2003). "Binding of the concave surface of the Sds22 superhelix to the alpha 4/alpha 5/alpha 6-triangle of protein phosphatase-1". J. Biol. Chem. 277 (49): 47331–7. doi: 10.1074/jbc.M206838200 . PMID   12226088.