PPP1R7

PPP1R7
Identifiers
Aliases	PPP1R7 , SDS22, protein phosphatase 1 regulatory subunit 7
External IDs	OMIM: 602877 MGI: 1913635 HomoloGene: 2032 GeneCards: PPP1R7
Gene location (Human)
Chr.	Chromosome 2 (human)
End	241,183,652 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	93,301,211 bp
RNA expression pattern
	Top expressed in
	nucleus accumbens; ; caudate nucleus; ; putamen; ; sperm; ; right uterine tube; ; prefrontal cortex; ; Brodmann area 9; ; monocyte; ; cingulate gyrus; ; amygdala;
	Top expressed in
	olfactory tubercle; ; nucleus accumbens; ; cingulate gyrus; ; seminiferous tubule; ; primitive streak; ; Region I of hippocampus proper; ; facial motor nucleus; ; internal carotid artery; ; amygdala; ; globus pallidus;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	enzyme regulator activity ; protein binding ; protein phosphatase regulator activity ;
Cellular component	cytoplasm ; extracellular exosome ; nucleus ; chromosome ;
Biological process	positive regulation of protein dephosphorylation ; chromosome segregation ; regulation of catalytic activity ; regulation of phosphoprotein phosphatase activity ; calcium activated phospholipid scrambling ;
	Sources:Amigo / QuickGO
Orthologs
	5510
	66385
	ENSG00000115685
	ENSMUSG00000026275
	Q15435
	Q3UM45
NM_001282409 ; NM_001282410 ; NM_001282411 ; NM_001282412 ; NM_001282413 ;
	NM_001282414 ; NM_002712
	NM_023200
NP_001269338 ; NP_001269339 ; NP_001269340 ; NP_001269341 ; NP_001269342 ;
	NP_001269343 ; NP_002703
	NP_075689
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 04, 2023

Protein phosphatase 1 regulatory subunit 7 is an enzyme that in humans is encoded by the PPP1R7 gene.^[5]^[6]^[7]^[8]

Related Research Articles

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Serine/threonine-protein phosphatase PP1-gamma catalytic subunit is an enzyme that in humans is encoded by the PPP1CC gene.

Serine/threonine-protein phosphatase PP1-beta catalytic subunit is an enzyme that in humans is encoded by the PPP1CB gene.

Nuclear inhibitor of protein phosphatase 1 is an enzyme that in humans is encoded by the PPP1R8 gene.

Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha is an enzyme that in humans is encoded by the PPP2R3A gene. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B'' family. The B'' family has been further divided into subfamilies. The product of this gene belongs to the alpha subfamily of regulatory subunit B''. Alternative splicing results in multiple transcript variants encoding different isoforms.

RNA polymerase II subunit A C-terminal domain phosphatase is an enzyme that in humans is encoded by the CTDP1 gene.

Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform (PP2BB) is an enzyme that in humans is encoded by the PPP3CB gene.

Calcineurin subunit B type 1 also known as protein phosphatase 2B regulatory subunit 1 is a protein that in humans is encoded by the PPP3R1 gene.

Polycomb protein EED is a protein that in humans is encoded by the EED gene.

Protein phosphatase 1 regulatory subunit 3A is an enzyme that in humans is encoded by the PPP1R3A gene.

Neurabin-2 is a protein that in humans is encoded by the PPP1R9B gene.

Serine/threonine-protein phosphatase 1 regulatory subunit 10 is an enzyme that in humans is encoded by the PPP1R10 gene. This gene lies within the major histocompatibility complex class I region on chromosome 6.

Protein phosphatase 1 regulatory subunit 11 is an enzyme that in humans is encoded by the PPP1R11 gene.

Maternal embryonic leucine zipper kinase (MELK) is an enzyme that in humans is encoded by the MELK gene. MELK is a serine/threonine kinase belonging to the family of AMPK/Snf1 protein kinases. MELK was first identified present as maternal mRNA in mouse embryos. MELK expression is elevated in a number of cancers and is an active research target for pharmacological inhibition.

Protein phosphatase 1 regulatory subunit 12B is an enzyme that in humans is encoded by the PPP1R12B gene.

Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform (PP2BC) is an enzyme that in humans is encoded by the PPP3CC gene.

Calcineurin subunit B type 2 is a protein that in humans is encoded by the PPP3R2 gene. Among its related pathways are MAPK signaling pathway and GPCR pathway. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is CHP1.

Protein phosphatase 1 regulatory subunit 14C is an enzyme that in humans is encoded by the PPP1R14C gene.

Solute carrier family 7, member 14 is a protein that in humans is encoded by the SLC7A14 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000115685 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026275 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Renouf S, Beullens M, Wera S, Van Eynde A, Sikela J, Stalmans W, Bollen M (Jan 1996). "Molecular cloning of a human polypeptide related to yeast sds22, a regulator of protein phosphatase-1". FEBS Lett. 375 (1–2): 75–8. doi:10.1016/0014-5793(95)01180-M. PMID 7498485. S2CID 41223011.
↑ Berry R, Stevens TJ, Walter NA, Wilcox AS, Rubano T, Hopkins JA, Weber J, Goold R, Soares MB, Sikela JM (Oct 1995). "Gene-based sequence-tagged-sites (STSs) as the basis for a human gene map". Nat Genet. 10 (4): 415–23. doi:10.1038/ng0895-415. PMID 7670491. S2CID 22277955.
↑ Ceulemans H, Van Eynde A, Perez-Callejon E, Beullens M, Stalmans W, Bollen M (Jun 1999). "Structure and splice products of the human gene encoding sds22, a putative mitotic regulator of protein phosphatase-1". Eur J Biochem. 262 (1): 36–42. doi: 10.1046/j.1432-1327.1999.00344.x . PMID 10231361.
↑ "Entrez Gene: PPP1R7 protein phosphatase 1, regulatory (inhibitor) subunit 7".

Lesage B, Beullens M, Pedelini L, et al. (2007). "A complex of catalytically inactive protein phosphatase-1 sandwiched between Sds22 and inhibitor-3". Biochemistry. 46 (31): 8909–19. doi:10.1021/bi7003119. PMID 17630778.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948 . PMID 17353931.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID 17081983. S2CID 7827573.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Ceulemans H, Vulsteke V, De Maeyer M, et al. (2003). "Binding of the concave surface of the Sds22 superhelix to the alpha 4/alpha 5/alpha 6-triangle of protein phosphatase-1". J. Biol. Chem. 277 (49): 47331–7. doi: 10.1074/jbc.M206838200 . PMID 12226088.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000115685 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026275 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7498485-5] Renouf S, Beullens M, Wera S, Van Eynde A, Sikela J, Stalmans W, Bollen M (Jan 1996). "Molecular cloning of a human polypeptide related to yeast sds22, a regulator of protein phosphatase-1". FEBS Lett. 375 (1–2): 75–8. doi:10.1016/0014-5793(95)01180-M. PMID 7498485. S2CID 41223011.

[pmid7670491-6] Berry R, Stevens TJ, Walter NA, Wilcox AS, Rubano T, Hopkins JA, Weber J, Goold R, Soares MB, Sikela JM (Oct 1995). "Gene-based sequence-tagged-sites (STSs) as the basis for a human gene map". Nat Genet. 10 (4): 415–23. doi:10.1038/ng0895-415. PMID 7670491. S2CID 22277955.

[pmid10231361-7] Ceulemans H, Van Eynde A, Perez-Callejon E, Beullens M, Stalmans W, Bollen M (Jun 1999). "Structure and splice products of the human gene encoding sds22, a putative mitotic regulator of protein phosphatase-1". Eur J Biochem. 262 (1): 36–42. doi: 10.1046/j.1432-1327.1999.00344.x . PMID 10231361.

[entrez-8] "Entrez Gene: PPP1R7 protein phosphatase 1, regulatory (inhibitor) subunit 7".

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PPP1R7

Related Research Articles

References

Further reading