PPP3CB

PPP3CB
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4OR9, 4ORA, 4ORC
Identifiers
Aliases	PPP3CB , CALNA2, CALNB, CNA2, PP2Bbeta, protein phosphatase 3 catalytic subunit beta
External IDs	OMIM: 114106 MGI: 107163 HomoloGene: 56429 GeneCards: PPP3CB
Gene location (Human) Chr. Chromosome 10 (human) [1] Band 10q22.2 Start 73,436,433 bp [1] End 73,496,024 bp [1]
Gene location (Mouse) Chr. Chromosome 14 (mouse) [2] Band 14|14 A3 Start 20,549,432 bp [2] End 20,596,641 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell biceps brachii middle temporal gyrus vastus lateralis muscle superior frontal gyrus orbitofrontal cortex Brodmann area 23 parietal lobe postcentral gyrus deltoid muscle Top expressed in subiculum triceps brachii muscle olfactory tubercle medial dorsal nucleus temporal muscle nucleus accumbens sternocleidomastoid muscle medial geniculate nucleus digastric muscle prefrontal cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding phosphoprotein phosphatase activity protein dimerization activity protein serine/threonine phosphatase activity metal ion binding calmodulin binding protein binding enzyme binding protein phosphatase 2B binding hydrolase activity calmodulin-dependent protein phosphatase activity Cellular component cytosol T-tubule plasma membrane calcineurin complex nucleoplasm Z disc cytoplasm glutamatergic synapse Biological process response to cytokine lymphangiogenesis regulation of insulin secretion calcineurin-NFAT signaling cascade memory learning regulation of synaptic plasticity T cell homeostasis positive regulation of transcription, DNA-templated negative regulation of T cell mediated cytotoxicity T cell proliferation Fc-epsilon receptor signaling pathway protein phosphorylation heart development T cell differentiation axon extension regulation of gene expression social behavior positive regulation of insulin secretion involved in cellular response to glucose stimulus locomotion involved in locomotory behavior T cell activation positive regulation of transcription by RNA polymerase II calcium-ion regulated exocytosis signal transduction dephosphorylation Wnt signaling pathway, calcium modulating pathway protein dephosphorylation regulation of synaptic vesicle endocytosis calcineurin-mediated signaling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5532 19056 Ensembl ENSG00000107758 ENSMUSG00000021816 UniProt P16298 P48453 RefSeq (mRNA) NM_001142353 NM_001142354 NM_001289968 NM_001289969 NM_021132 NM_008914 NM_001310426 NM_001310427 RefSeq (protein) NP_001135825 NP_001135826 NP_001276897 NP_001276898 NP_066955 NP_001297355 NP_001297356 NP_032940 Location (UCSC) Chr 10: 73.44 – 73.5 Mb Chr 14: 20.55 – 20.6 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform (PP2BB) is an enzyme that in humans is encoded by the PPP3CB gene. ^{[5] [6] [7] [8]}

References

1. GRCh38: Ensembl release 89: ENSG00000107758 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021816 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Universal protein resource accession number P16298 for "Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform" at UniProt.
6. Giri PR, Higuchi S, Kincaid RL (Jan 1992). "Chromosomal mapping of the human genes for the calmodulin-dependent protein phosphatase (calcineurin) catalytic subunit". Biochem Biophys Res Commun. 181 (1): 252–8. doi:10.1016/S0006-291X(05)81410-X. PMID   1659808.
7. Guerini D, Krinks MH, Sikela JM, Hahn WE, Klee CB (Mar 1990). "Isolation and sequence of a cDNA clone for human calcineurin B, the Ca2+-binding subunit of the Ca2+/calmodulin-stimulated protein phosphatase". DNA. 8 (9): 675–82. doi:10.1089/dna.1.1989.8.675. PMID   2558868.
8. "Entrez Gene: PPP3CB protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform".

Further reading

• Chen MX, Chen YH, Cohen PT (1992). "Polymerase chain reactions using Saccharomyces, Drosophila and human DNA predict a large family of protein serine/threonine phosphatases". FEBS Lett. 306 (1): 54–8. doi:10.1016/0014-5793(92)80836-6. PMID   1321058. S2CID   31397906.
• McPartlin AE, Barker HM, Cohen PT (1991). "Identification of a third alternatively spliced cDNA encoding the catalytic subunit of protein phosphatase 2B beta". Biochim. Biophys. Acta. 1088 (2): 308–10. doi:10.1016/0167-4781(91)90069-x. PMID   1848109.
• Guerini D, Klee CB (1990). "Cloning of human calcineurin A: evidence for two isozymes and identification of a polyproline structural domain". Proc. Natl. Acad. Sci. U.S.A. 86 (23): 9183–7. doi: 10.1073/pnas.86.23.9183 . PMC   298458 . PMID   2556704.
• Shibasaki F, McKeon F (1995). "Calcineurin functions in Ca(2+)-activated cell death in mammalian cells". J. Cell Biol. 131 (3): 735–43. doi:10.1083/jcb.131.3.735. PMC   2120616 . PMID   7593193.
• Muramatsu T, Kincaid RL (1993). "Molecular cloning of a full-length cDNA encoding the catalytic subunit of human calmodulin-dependent protein phosphatase (calcineurin A alpha)". Biochim. Biophys. Acta. 1178 (1): 117–20. doi:10.1016/0167-4889(93)90117-8. PMID   8392375.
• Kissinger CR, Parge HE, Knighton DR, et al. (1996). "Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex". Nature. 378 (6557): 641–4. Bibcode:1995Natur.378..641K. doi:10.1038/378641a0. PMID   8524402. S2CID   4337105.
• Wang MG, Yi H, Guerini D, et al. (1997). "Calcineurin A alpha (PPP3CA), calcineurin A beta (PPP3CB) and calcineurin B (PPP3R1) are located on human chromosomes 4, 10q21→q22 and 2p16→p15 respectively". Cytogenet. Cell Genet. 72 (2–3): 236–41. doi:10.1159/000134198. PMID   8978785.
• Sun L, Youn HD, Loh C, et al. (1998). "Cabin 1, a negative regulator for calcineurin signaling in T lymphocytes". Immunity. 8 (6): 703–11. doi: 10.1016/S1074-7613(00)80575-0 . PMID   9655484.
• Aramburu J, Garcia-Cózar F, Raghavan A, et al. (1998). "Selective inhibition of NFAT activation by a peptide spanning the calcineurin targeting site of NFAT". Mol. Cell. 1 (5): 627–37. doi: 10.1016/S1097-2765(00)80063-5 . PMID   9660947.
• Okamura H, Aramburu J, García-Rodríguez C, et al. (2000). "Concerted dephosphorylation of the transcription factor NFAT1 induces a conformational switch that regulates transcriptional activity". Mol. Cell. 6 (3): 539–50. doi: 10.1016/S1097-2765(00)00053-8 . PMID   11030334.
• Frey N, Richardson JA, Olson EN (2001). "Calsarcins, a novel family of sarcomeric calcineurin-binding proteins". Proc. Natl. Acad. Sci. U.S.A. 97 (26): 14632–7. Bibcode:2000PNAS...9714632F. doi: 10.1073/pnas.260501097 . PMC   18970 . PMID   11114196.
• Esau C, Boes M, Youn HD, et al. (2001). "Deletion of calcineurin and myocyte enhancer factor 2 (MEF2) binding domain of Cabin1 results in enhanced cytokine gene expression in T cells". J. Exp. Med. 194 (10): 1449–59. doi:10.1084/jem.194.10.1449. PMC   2193671 . PMID   11714752.
• Frey N, Olson EN (2002). "Calsarcin-3, a novel skeletal muscle-specific member of the calsarcin family, interacts with multiple Z-disc proteins". J. Biol. Chem. 277 (16): 13998–4004. doi: 10.1074/jbc.M200712200 . PMID   11842093.
• Banerjee A, Banks AS, Nawijn MC, et al. (2002). "Cutting edge: Suppressor of cytokine signaling 3 inhibits activation of NFATp". J. Immunol. 168 (9): 4277–81. doi: 10.4049/jimmunol.168.9.4277 . PMID   11970967.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Bennasser Y, Badou A, Tkaczuk J, Bahraoui E (2003). "Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha". Virology. 303 (1): 174–80. doi: 10.1006/viro.2002.1676 . PMID   12482669.
• Genescà L, Aubareda A, Fuentes JJ, et al. (2003). "Phosphorylation of calcipressin 1 increases its ability to inhibit calcineurin and decreases calcipressin half-life". Biochem. J. 374 (Pt 2): 567–75. doi:10.1042/BJ20030267. PMC   1223619 . PMID   12809556.
• Bell O, Gaberman E, Kilav R, et al. (2005). "The protein phosphatase calcineurin determines basal parathyroid hormone gene expression". Mol. Endocrinol. 19 (2): 516–26. doi:10.1210/me.2004-0108. PMID   15514034. S2CID   27672093.