PPP3CC

PPP3CC
Identifiers
Aliases	PPP3CC , CALNA3, CNA3, PP2Bgamma, protein phosphatase 3 catalytic subunit gamma
External IDs	OMIM: 114107 MGI: 107162 HomoloGene: 68475 GeneCards: PPP3CC
Gene location (Human)
Chr.	Chromosome 8 (human)
End	22,541,142 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	70,289,471 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; Achilles tendon; ; left ventricle; ; vastus lateralis muscle; ; right lung; ; left coronary artery; ; deltoid muscle; ; tibial nerve; ; lymph node; ; right coronary artery;
	Top expressed in
	spermatocyte; ; spermatid; ; seminiferous tubule; ; interventricular septum; ; extensor digitorum longus muscle; ; proximal tubule; ; olfactory epithelium; ; plantaris muscle; ; quadriceps femoris muscle; ; spleen;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	phosphoprotein phosphatase activity ; protein binding ; hydrolase activity ; metal ion binding ; calmodulin binding ; calmodulin-dependent protein phosphatase activity ;
Cellular component	cytosol ; cytoplasm ; presynapse ; glutamatergic synapse ; presynaptic cytosol ; calcineurin complex ; mitochondrion ;
Biological process	brain development ; protein dephosphorylation ; calcineurin-NFAT signaling cascade ; positive regulation of synaptic vesicle endocytosis ; regulation of synaptic vesicle endocytosis ; calcineurin-mediated signaling ; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway ;
	Sources:Amigo / QuickGO
Orthologs
	5533
	19057
	ENSG00000120910
	ENSMUSG00000022092
	P48454
	P48455
	NM_001243974 ; NM_001243975 ; NM_005605
	NM_008915 ; NM_001304991 ; NM_001304992 ; NM_001360229
	NP_001230903 ; NP_001230904 ; NP_005596
	NP_001291920 ; NP_001291921 ; NP_032941 ; NP_001347158
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated April 12, 2024

Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform (PP2BC) is an enzyme that in humans is encoded by the PPP3CC gene.^[5]^[6]

Calmodulin-dependent protein phosphatase, calcineurin, is involved in a wide range of biologic activities, acting as a Ca(2+)-dependent modifier of phosphorylation status.

In testis, the motility of the sperm is thought to be controlled by cAMP-dependent phosphorylation and a unique form of calcineurin appears to be associated with the flagellum. The calcineurin holoenzyme is composed of catalytic and regulatory subunits of 60 and 18 kD, respectively.

At least 3 genes, calcineurin A-alpha (CALNA1; MIM 114105), calcineurin A-beta (CALNA2; MIM 114106), and calcineurin A-gamma (CALNA3), have been cloned for the catalytic subunit. These genes have been identified in humans, mice, and rats, and are highly conserved between species (90 to 95% amino acid identity).[supplied by OMIM]^[6]

Related Research Articles

Calcineurin (CaN) is a calcium and calmodulin dependent serine/threonine protein phosphatase. It activates the T cells of the immune system and can be blocked by drugs. Calcineurin activates nuclear factor of activated T cell cytoplasmic (NFATc), a transcription factor, by dephosphorylating it. The activated NFATc is then translocated into the nucleus, where it upregulates the expression of interleukin 2 (IL-2), which, in turn, stimulates the growth and differentiation of the T cell response. Calcineurin is the target of a class of drugs called calcineurin inhibitors, which include ciclosporin, voclosporin, pimecrolimus and tacrolimus.

Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform is an enzyme that is encoded by the PPP2CA gene.

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform is an enzyme that in humans is encoded by the PPP2R2B gene.

Serine/threonine-protein phosphatase PP1-gamma catalytic subunit is an enzyme that in humans is encoded by the PPP1CC gene.

Serine/threonine-protein phosphatase PP1-beta catalytic subunit is an enzyme that in humans is encoded by the PPP1CB gene.

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform is an enzyme that in humans is encoded by the PPP2R5C gene.

cAMP-dependent protein kinase catalytic subunit beta is an enzyme that in humans is encoded by the PRKACB gene.

Calcium/calmodulin-dependent protein kinase type II delta chain is an enzyme that in humans is encoded by the CAMK2D gene.

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform is an enzyme that in humans is encoded by the PPP2R2C gene.

Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform (PP2BB) is an enzyme that in humans is encoded by the PPP3CB gene.

Calcineurin subunit B type 1 also known as protein phosphatase 2B regulatory subunit 1 is a protein that in humans is encoded by the PPP3R1 gene.

5'-AMP-activated protein kinase subunit gamma-1 is an enzyme that in humans is encoded by the PRKAG1 gene.

Protein phosphatase 1 regulatory subunit 3A is an enzyme that in humans is encoded by the PPP1R3A gene.

5'-AMP-activated protein kinase subunit beta-2 is an enzyme that in humans is encoded by the PRKAB2 gene.

Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial is an enzyme that in humans is encoded by the IDH3B gene.

Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform is an enzyme that in humans is encoded by the PHKA1 gene. It is the muscle isoform of Phosphorylase kinase (PhK).

Calcineurin subunit B type 2 is a protein that in humans is encoded by the PPP3R2 gene. Among its related pathways are MAPK signaling pathway and GPCR pathway. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is CHP1.

Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform (PP2BA) is a protein that in humans is encoded by the PPP3CA gene.

Dual specificity protein phosphatase 15 is an enzyme that in humans is encoded by the DUSP15 gene.

Ubiquitin-Protein Ligase E3B (UBE3B) is an enzyme encoded by UBE3B gene in humans. UBE3B has an N-terminal IQ motif, which mediates calcium-independent calmodulin binding and a large C-terminal catalytic HECT domain.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000120910 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022092 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Muramatsu T, Kincaid RL (Nov 1992). "Molecular cloning and chromosomal mapping of the human gene for the testis-specific catalytic subunit of calmodulin-dependent protein phosphatase (calcineurin A)". Biochem Biophys Res Commun. 188 (1): 265–71. doi:10.1016/0006-291X(92)92379-C. PMID 1339277.
1 2 "Entrez Gene: PPP3CC protein phosphatase 3 (formerly 2B), catalytic subunit, gamma isoform".

Esau C, Boes M, Youn HD, et al. (2001). "Deletion of Calcineurin and Myocyte Enhancer Factor 2 (MEF2) Binding Domain of Cabin1 Results in Enhanced Cytokine Gene Expression in T Cells". J. Exp. Med. 194 (10): 1449–59. doi:10.1084/jem.194.10.1449. PMC 2193671 . PMID 11714752.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Bennasser Y, Badou A, Tkaczuk J, et al. (2003). "Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha". Virology. 303 (1): 174–80. doi: 10.1006/viro.2002.1676 . PMID 12482669.
Gerber DJ, Hall D, Miyakawa T, et al. (2003). "Evidence for association of schizophrenia with genetic variation in the 8p21.3 gene, PPP3CC, encoding the calcineurin gamma subunit". Proc. Natl. Acad. Sci. U.S.A. 100 (15): 8993–8. Bibcode:2003PNAS..100.8993G. doi: 10.1073/pnas.1432927100 . PMC 166426 . PMID 12851458.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.
Eastwood SL, Burnet PW, Harrison PJ (2005). "Decreased hippocampal expression of the susceptibility gene PPP3CC and other calcineurin subunits in schizophrenia". Biol. Psychiatry. 57 (7): 702–10. doi:10.1016/j.biopsych.2004.12.029. PMID 15820226. S2CID 39744063.
Kinoshita Y, Suzuki T, Ikeda M, et al. (2006). "No association with the calcineurin A gamma subunit gene (PPP3CC) haplotype to Japanese schizophrenia". Journal of Neural Transmission. 112 (9): 1255–62. doi:10.1007/s00702-004-0261-5. PMID 15843870. S2CID 143604.
Liu YL, Fann CS, Liu CM, et al. (2008). "More evidence supports the association of PPP3CC with schizophrenia". Mol. Psychiatry. 12 (10): 966–74. doi: 10.1038/sj.mp.4001977 . PMID 17339875.
Horiuchi Y, Ishiguro H, Koga M, et al. (2008). "Support for association of the PPP3CC gene with schizophrenia". Mol. Psychiatry. 12 (10): 891–3. doi: 10.1038/sj.mp.4002019 . PMID 17895921.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000120910 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022092 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1339277-5] Muramatsu T, Kincaid RL (Nov 1992). "Molecular cloning and chromosomal mapping of the human gene for the testis-specific catalytic subunit of calmodulin-dependent protein phosphatase (calcineurin A)". Biochem Biophys Res Commun. 188 (1): 265–71. doi:10.1016/0006-291X(92)92379-C. PMID 1339277.

[entrez-6] 1 2 "Entrez Gene: PPP3CC protein phosphatase 3 (formerly 2B), catalytic subunit, gamma isoform".

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PPP3CC

Related Research Articles

References

Further reading