PPP4R1

PPP4R1
Identifiers
Aliases	PPP4R1 , MEG1, PP4(Rmeg), PP4R1, protein phosphatase 4 regulatory subunit 1
External IDs	OMIM: 604908; MGI: 1917601; HomoloGene: 81737; GeneCards: PPP4R1; OMA:PPP4R1 - orthologs
Gene location (Human) Chr. Chromosome 18 (human) [1] Band 18p11.22 Start 9,546,791 bp [1] End 9,615,240 bp [1]
Gene location (Mouse) Chr. Chromosome 17 (mouse) [2] Band 17|17 E1.1 Start 66,089,568 bp [2] End 66,148,921 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm gingival epithelium mucosa of pharynx visceral pleura Achilles tendon oral cavity amniotic fluid epithelium of colon ventricular zone nasal epithelium Top expressed in spermatid tail of embryo granulocyte intestinal villus primitive streak genital tubercle testicle Paneth cell vas deferens spermatocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding phosphoprotein phosphatase activity protein phosphatase regulator activity protein serine/threonine phosphatase activity Cellular component protein phosphatase 4 complex Biological process protein phosphorylation regulation of catalytic activity signal transduction protein dephosphorylation regulation of phosphoprotein phosphatase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9989 70351 Ensembl ENSG00000154845 ENSMUSG00000061950 UniProt Q8TF05 Q8K2V1 RefSeq (mRNA) NM_001042388 NM_005134 NM_001382562 NM_001114131 NM_146081 RefSeq (protein) NP_001035847 NP_005125 NP_001369491 NP_001107603 NP_666193 Location (UCSC) Chr 18: 9.55 – 9.62 Mb Chr 17: 66.09 – 66.15 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Serine/threonine-protein phosphatase 4 regulatory subunit 1 is an enzyme that in humans is encoded by the PPP4R1 gene. ^{[5] [6]}

Interactions

PPP4R1 has been shown to interact with PPP4C. ^{[7] [8] [9]}

References

1. GRCh38: Ensembl release 89: ENSG00000154845 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000061950 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kloeker S, Wadzinski BE (Feb 1999). "Purification and identification of a novel subunit of protein serine/threonine phosphatase 4". The Journal of Biological Chemistry. 274 (9): 5339–47. doi: 10.1074/jbc.274.9.5339 . PMID   10026142.
6. "Entrez Gene: PPP4R1 protein phosphatase 4, regulatory subunit 1".
7. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.
8. Chen GI, Tisayakorn S, Jorgensen C, D'Ambrosio LM, Goudreault M, Gingras AC (Oct 2008). "PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4". The Journal of Biological Chemistry. 283 (43): 29273–84. doi: 10.1074/jbc.M803443200 . PMC   2662017 . PMID   18715871.
9. Gingras AC, Caballero M, Zarske M, Sanchez A, Hazbun TR, Fields S, Sonenberg N, Hafen E, Raught B, Aebersold R (Nov 2005). "A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity". Molecular & Cellular Proteomics. 4 (11): 1725–40. doi: 10.1074/mcp.M500231-MCP200 . PMID   16085932.

Further reading

• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.
• Zhang X, Ozawa Y, Lee H, Wen YD, Tan TH, Wadzinski BE, Seto E (Apr 2005). "Histone deacetylase 3 (HDAC3) activity is regulated by interaction with protein serine/threonine phosphatase 4". Genes & Development. 19 (7): 827–39. doi:10.1101/gad.1286005. PMC   1074320 . PMID   15805470.
• Wada T, Miyata T, Inagi R, Nangaku M, Wagatsuma M, Suzuki D, Wadzinski BE, Okubo K, Kurokawa K (Dec 2001). "Cloning and characterization of a novel subunit of protein serine/threonine phosphatase 4 from mesangial cells". Journal of the American Society of Nephrology. 12 (12): 2601–8. doi: 10.1681/ASN.V12122601 . PMID   11729228.
• Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (Apr 1997). "Large-scale concatenation cDNA sequencing". Genome Research. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC   139146 . PMID   9110174.
• Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Apr 1996). "A "double adaptor" method for improved shotgun library construction". Analytical Biochemistry. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID   8619474.