PREPL

PREPL
Identifiers
Aliases	PREPL , prolyl endopeptidase-like, CMS22, prolyl endopeptidase like
External IDs	OMIM: 609557; MGI: 2441932; HomoloGene: 15481; GeneCards: PREPL; OMA:PREPL - orthologs
Gene location (Human) Chr. Chromosome 2 (human) [1] Band 2p21 Start 44,316,281 bp [1] End 44,361,862 bp [1]
Gene location (Mouse) Chr. Chromosome 17 (mouse) [2] Band 17|17 E4 Start 85,370,898 bp [2] End 85,397,669 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Brodmann area 23 endothelial cell middle temporal gyrus postcentral gyrus pars compacta lateral nuclear group of thalamus external globus pallidus pons pars reticulata entorhinal cortex Top expressed in ventromedial nucleus paraventricular nucleus of hypothalamus lateral hypothalamus ventral tegmental area pontine nuclei medial geniculate nucleus dorsomedial hypothalamic nucleus medial vestibular nucleus inferior colliculi central gray substance of midbrain More reference expression data BioGPS More reference expression data
Gene ontology Molecular function serine-type exopeptidase activity peptidase activity serine-type peptidase activity hydrolase activity serine-type endopeptidase activity protein binding Cellular component cytoplasm cytosol Golgi apparatus cytoskeleton Biological process proteolysis regulation of synaptic vesicle exocytosis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9581 213760 Ensembl ENSG00000138078 ENSMUSG00000024127 UniProt Q4J6C6 Q8C167 RefSeq (mRNA) NM_001042385 NM_001042386 NM_001171603 NM_001171606 NM_001171613 NM_001171617 NM_006036 NM_001374275 NM_001374276 NM_001374277 NM_001163622 NM_001163623 NM_001163624 NM_145984 RefSeq (protein) NP_001035844 NP_001035845 NP_001165074 NP_001165077 NP_001165084 NP_001165088 NP_006027 NP_001361204 NP_001361205 NP_001361206 NP_001157094 NP_001157095 NP_001157096 NP_666096 Location (UCSC) Chr 2: 44.32 – 44.36 Mb Chr 17: 85.37 – 85.4 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Prolyl endopeptidase-like is an enzyme that in humans is encoded by the PREPL gene. ^{[5] [6]}

PREPL belongs to the prolyloligopeptidase subfamily of serine peptidases (Parvari et al., 2005).[supplied by OMIM] ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000138078 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024127 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Parvari R, Brodyansky I, Elpeleg O, Moses S, Landau D, Hershkovitz E (Sep 2001). "A recessive contiguous gene deletion of chromosome 2p16 associated with cystinuria and a mitochondrial disease". Am J Hum Genet. 69 (4): 869–875. doi:10.1086/323624. PMC   1226072 . PMID   11524703.
6. "Entrez Gene: PREPL prolyl endopeptidase-like".

Further reading

• Martens K, Derua R, Meulemans S, et al. (2006). "PREPL: a putative novel oligopeptidase propelled into the limelight". Biol. Chem. 387 (7): 879–883. doi:10.1515/BC.2006.111. PMID   16913837. S2CID   7983864.
• Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, et al. (1995). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening". Genomics. 23 (1): 42–50. doi:10.1006/geno.1994.1457. hdl: 10669/15162 . PMID   7829101.
• Ishikawa K, Nagase T, Nakajima D, et al. (1998). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 4 (5): 307–313. doi: 10.1093/dnares/4.5.307 . PMID   9455477.
• Kim DK, Kanai Y, Choi HW, et al. (2002). "Characterization of the system L amino acid transporter in T24 human bladder carcinoma cells". Biochim. Biophys. Acta. 1565 (1): 112–122. doi:10.1016/S0005-2736(02)00516-3. PMID   12225859.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Parvari R, Gonen Y, Alshafee I, et al. (2005). "The 2p21 deletion syndrome: characterization of the transcription content". Genomics. 86 (2): 195–211. doi:10.1016/j.ygeno.2005.04.001. PMID   15913950.
• Szeltner Z, Alshafee I, Juhász T, et al. (2005). "The PREPL A protein, a new member of the prolyl oligopeptidase family, lacking catalytic activity". Cell. Mol. Life Sci. 62 (19–20): 2376–2381. doi:10.1007/s00018-005-5262-5. PMC   11139102 . PMID   16143824. S2CID   11081394.
• Jaeken J, Martens K, Francois I, et al. (2006). "Deletion of PREPL, a gene encoding a putative serine oligopeptidase, in patients with hypotonia-cystinuria syndrome". Am. J. Hum. Genet. 78 (1): 38–51. doi:10.1086/498852. PMC   1380222 . PMID   16385448.