PRMT3

PRMT3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2FYT, 3SMQ, 4HSG, 4QQN, 4RYL
Identifiers
Aliases	PRMT3 , HRMT1L3, protein arginine methyltransferase 3
External IDs	OMIM: 603190; MGI: 1919224; HomoloGene: 24255; GeneCards: PRMT3; OMA:PRMT3 - orthologs
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11p15.1 Start 20,387,558 bp [1] End 20,509,338 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7|7 B4 Start 49,428,094 bp [2] End 49,508,013 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone Achilles tendon gonad gingival epithelium gastrocnemius muscle left lobe of thyroid gland germinal epithelium right lobe of thyroid gland islet of Langerhans C1 segment Top expressed in genital tubercle tail of embryo condyle cumulus cell fossa substantia nigra Paneth cell primitive streak endothelial cell of lymphatic vessel epiblast More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding methyltransferase activity transferase activity protein binding protein-arginine N-methyltransferase activity nucleic acid binding histone-arginine N-methyltransferase activity protein-arginine omega-N asymmetric methyltransferase activity ribosome binding Cellular component ribosome cytoplasm cytosol nucleus Biological process methylation negative regulation of protein ubiquitination peptidyl-arginine N-methylation protein methylation regulation of transcription, DNA-templated peptidyl-arginine methylation, to asymmetrical-dimethyl arginine histone arginine methylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10196 71974 Ensembl ENSG00000185238 ENSMUSG00000030505 UniProt O60678 Q922H1 RefSeq (mRNA) NM_001145166 NM_001145167 NM_005788 NM_133740 RefSeq (protein) NP_001138638 NP_001138639 NP_005779 NP_598501 Location (UCSC) Chr 11: 20.39 – 20.51 Mb Chr 7: 49.43 – 49.51 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Protein arginine N-methyltransferase 3 is an enzyme that in humans is encoded by the PRMT3 gene. ^{[5] [6]}

Interactions

PRMT3 has been shown to interact with RPS2. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000185238 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030505 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Tang J, Gary JD, Clarke S, Herschman HR (July 1998). "PRMT 3, a type I protein arginine N-methyltransferase that differs from PRMT1 in its oligomerization, subcellular localization, substrate specificity, and regulation". The Journal of Biological Chemistry. 273 (27): 16935–45. doi: 10.1074/jbc.273.27.16935 . PMID   9642256.
6. "Entrez Gene: PRMT3 protein arginine methyltransferase 3".
7. Choi S, Jung CR, Kim JY, Im DS (September 2008). "PRMT3 inhibits ubiquitination of ribosomal protein S2 and together forms an active enzyme complex". Biochimica et Biophysica Acta (BBA) - General Subjects. 1780 (9): 1062–9. doi:10.1016/j.bbagen.2008.05.010. PMID   18573314.

Further reading

• Singh V, Miranda TB, Jiang W, Frankel A, Roemer ME, Robb VA, et al. (October 2004). "DAL-1/4.1B tumor suppressor interacts with protein arginine N-methyltransferase 3 (PRMT3) and inhibits its ability to methylate substrates in vitro and in vivo". Oncogene. 23 (47): 7761–71. doi: 10.1038/sj.onc.1208057 . PMID   15334060.
• Bachand F, Silver PA (July 2004). "PRMT3 is a ribosomal protein methyltransferase that affects the cellular levels of ribosomal subunits". The EMBO Journal. 23 (13): 2641–50. doi:10.1038/sj.emboj.7600265. PMC   449775 . PMID   15175657.
• Smith JJ, Rücknagel KP, Schierhorn A, Tang J, Nemeth A, Linder M, et al. (May 1999). "Unusual sites of arginine methylation in Poly(A)-binding protein II and in vitro methylation by protein arginine methyltransferases PRMT1 and PRMT3". The Journal of Biological Chemistry. 274 (19): 13229–34. doi: 10.1074/jbc.274.19.13229 . PMID   10224081.

External links

• PRMT3 human gene location in the UCSC Genome Browser .
• PRMT3 human gene details in the UCSC Genome Browser .