PRPSAP1

PRPSAP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2C4K
Identifiers
Aliases	PRPSAP1 , PAP39, phosphoribosyl pyrophosphate synthetase-associated protein 1, phosphoribosyl pyrophosphate synthetase associated protein 1
External IDs	OMIM: 601249 MGI: 1915013 HomoloGene: 55687 GeneCards: PRPSAP1
Gene location (Human)
Chr.	Chromosome 17 (human)
End	76,384,521 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	116,385,028 bp
RNA expression pattern
	Top expressed in
	parotid gland; ; right lobe of thyroid gland; ; minor salivary gland; ; left lobe of thyroid gland; ; right lung; ; tibial nerve; ; right lobe of liver; ; right uterine tube; ; canal of the cervix; ; gallbladder;
	Top expressed in
	Paneth cell; ; internal carotid artery; ; external carotid artery; ; duodenum; ; crypt of lieberkuhn of small intestine; ; left lobe of liver; ; condyle; ; jejunum; ; fossa; ; motor neuron;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	enzyme inhibitor activity ; ribose phosphate diphosphokinase activity ; magnesium ion binding ; protein binding ; identical protein binding ; enzyme regulator activity ;
Cellular component	ribose phosphate diphosphokinase complex ; cytoplasm ;
Biological process	nucleotide biosynthetic process ; nucleobase-containing compound metabolic process ; negative regulation of catalytic activity ; 5-phosphoribose 1-diphosphate biosynthetic process ; purine nucleotide biosynthetic process ; regulation of catalytic activity ;
	Sources:Amigo / QuickGO
Orthologs
	5635
	67763
	ENSG00000161542
	ENSMUSG00000015869
	Q14558
	Q9D0M1
	NM_002766 ; NM_001330503 ; NM_001366236
	NM_026364
	NP_001317432 ; NP_002757 ; NP_001353165
	NP_080640 ; NP_001391595 ; NP_001391596 ; NP_001391597 ; NP_001391598
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 14, 2022

Phosphoribosyl pyrophosphate synthetase-associated protein 1 is an enzyme that in humans is encoded by the PRPSAP1 gene.^[5]^[6]

Related Research Articles

Amidophosphoribosyltransferase (ATase), also known as glutamine phosphoribosylpyrophosphate amidotransferase (GPAT), is an enzyme responsible for catalyzing the conversion of 5-phosphoribosyl-1-pyrophosphate (PRPP) into 5-phosphoribosyl-1-amine (PRA), using the amine group from a glutamine side-chain. This is the committing step in de novo purine synthesis. In humans it is encoded by the PPAT gene. ATase is a member of the purine/pyrimidine phosphoribosyltransferase family.

Prokineticin receptor 1, also known as PKR₁, is a human protein encoded by the PROKR1 gene.

DnaJ homolog subfamily A member 1 is a protein that in humans is encoded by the DNAJA1 gene.

Phosducin-like protein is a protein that in humans is encoded by the PDCL gene.

60S ribosomal protein L4 is a protein that in humans is encoded by the RPL4 gene.

Acylamino-acid-releasing enzyme is an enzyme that in humans is encoded by the APEH gene.

40S ribosomal protein S9 is a protein that in humans is encoded by the RPS9 gene.

S100 calcium-binding protein A3 (S100A3) is a protein that in humans is encoded by the S100A3 gene.

Thiamin pyrophosphokinase 1 is an enzyme that in humans is encoded by the TPK1 gene.

Threonyl-tRNA synthetase, cytoplasmic is an enzyme that in humans is encoded by the TARS gene.

Developmentally-regulated GTP-binding protein 1 is a protein that in humans is encoded by the DRG1 gene.

Krueppel-like factor 12 is a protein that in humans is encoded by the KLF12 gene.

Mitochondrial 2-oxoglutarate/malate carrier protein is a protein that in humans is encoded by the SLC25A11 gene. Inactivating mutations in this gene predispose to metastasic paraganglioma.

Nuclear receptor-binding factor 2 is a protein that in humans is encoded by the NRBF2 gene.

Fibrinogen-like protein 1 (FGL-1) is a protein that is structurally related to fibrinogen. In humans, FGL-1 is encoded by the FGL1 gene. Four splice variants exist for this gene.

60S ribosomal protein L9 is a protein that in humans is encoded by the RPL9 gene.

Zinc finger protein 267 is a protein that in humans is encoded by the ZNF267 gene.

Tetraspanin-3 is a protein that in humans is encoded by the TSPAN3 gene.

CTP synthase 2 is an enzyme that in humans is encoded by the CTPS2 gene.

Phosphoribosyl pyrophosphate synthetase-associated protein 2 is a protein that in humans is encoded by the PRPSAP2 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000161542 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000015869 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Ishizuka T, Ahmad I, Kita K, Sonoda T, Ishijima S, Sawa K, Suzuki N, Tatibana M (Jan 1997). "The human phosphoribosylpyrophosphate synthetase-associated protein 39 gene (PRPSAP1) is located in the chromosome region 17q24-q25". Genomics. 33 (2): 332–4. doi:10.1006/geno.1996.0207. PMID 8660991.
↑ "Entrez Gene: PRPSAP1 phosphoribosyl pyrophosphate synthetase-associated protein 1".

Tatibana M, Kita K, Taira M, et al. (1995). "Mammalian phosphoribosyl-pyrophosphate synthetase". Adv. Enzyme Regul. 35: 229–49. doi:10.1016/0065-2571(94)00017-W. PMID 7572345.
Kita K, Ishizuka T, Ishijima S, et al. (1994). "A novel 39-kDa phosphoribosylpyrophosphate synthetase-associated protein of rat liver. Cloning, high sequence similarity to the catalytic subunits, and a negative regulatory role". J. Biol. Chem. 269 (11): 8334–40. doi: 10.1016/S0021-9258(17)37198-3 . PMID 8132556.
Ishizuka T, Kita K, Sonoda T, et al. (1996). "Cloning and sequencing of human complementary DNA for the phosphoribosylpyrophosphate synthetase-associated protein 39". Biochim. Biophys. Acta. 1306 (1): 27–30. doi:10.1016/0167-4781(96)00030-9. PMID 8611620.
Ishijima S, Asai T, Kita K, et al. (1997). "Partial reconstitution of mammalian phosphoribosylpyrophosphate synthetase in Escherichia coli cells. Coexpression of catalytic subunits with the 39-kDa associated protein leads to formation of soluble multimeric complexes of various compositions". Biochim. Biophys. Acta. 1342 (1): 28–36. doi:10.1016/s0167-4838(97)00077-0. PMID 9366267.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948 . PMID 17353931.

This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by expanding it.

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000161542 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000015869 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8660991-5] Ishizuka T, Ahmad I, Kita K, Sonoda T, Ishijima S, Sawa K, Suzuki N, Tatibana M (Jan 1997). "The human phosphoribosylpyrophosphate synthetase-associated protein 39 gene (PRPSAP1) is located in the chromosome region 17q24-q25". Genomics. 33 (2): 332–4. doi:10.1006/geno.1996.0207. PMID 8660991.

[entrez-6] "Entrez Gene: PRPSAP1 phosphoribosyl pyrophosphate synthetase-associated protein 1".

[1]

[2]

[3]

[4]

[5]

[6]

PRPSAP1

Related Research Articles

References

Further reading