PRPSAP1

PRPSAP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2C4K
Identifiers
Aliases	PRPSAP1 , PAP39, phosphoribosyl pyrophosphate synthetase-associated protein 1, phosphoribosyl pyrophosphate synthetase associated protein 1
External IDs	OMIM: 601249; MGI: 1915013; HomoloGene: 55687; GeneCards: PRPSAP1; OMA:PRPSAP1 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) [1] Band 17q25.1 Start 76,309,478 bp [1] End 76,384,521 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11|11 E2 Start 116,361,671 bp [2] End 116,385,028 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in parotid gland right lobe of thyroid gland gonad minor salivary glands left lobe of thyroid gland left testis right testis right lung ventricular zone right adrenal cortex Top expressed in Paneth cell internal carotid artery epithelium of lens external carotid artery duodenum crypt of lieberkuhn of small intestine endothelial cell of lymphatic vessel left lobe of liver condyle jejunum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function enzyme inhibitor activity ribose phosphate diphosphokinase activity magnesium ion binding protein binding identical protein binding enzyme regulator activity Cellular component ribose phosphate diphosphokinase complex cytoplasm Biological process nucleotide biosynthetic process nucleobase-containing compound metabolic process negative regulation of catalytic activity 5-phosphoribose 1-diphosphate biosynthetic process purine nucleotide biosynthetic process regulation of catalytic activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5635 67763 Ensembl ENSG00000161542 ENSMUSG00000015869 UniProt Q14558 Q9D0M1 RefSeq (mRNA) NM_002766 NM_001330503 NM_001366236 NM_026364 RefSeq (protein) NP_001317432 NP_002757 NP_001353165 NP_080640 NP_001391595 NP_001391596 NP_001391597 NP_001391598 Location (UCSC) Chr 17: 76.31 – 76.38 Mb Chr 11: 116.36 – 116.39 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Phosphoribosyl pyrophosphate synthetase-associated protein 1 is an enzyme that in humans is encoded by the PRPSAP1 gene. ^{[5] [6]}

References

1. GRCh38: Ensembl release 89: ENSG00000161542 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000015869 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ishizuka T, Ahmad I, Kita K, Sonoda T, Ishijima S, Sawa K, Suzuki N, Tatibana M (Jan 1997). "The human phosphoribosylpyrophosphate synthetase-associated protein 39 gene (PRPSAP1) is located in the chromosome region 17q24-q25". Genomics. 33 (2): 332–4. doi:10.1006/geno.1996.0207. PMID   8660991.
6. "Entrez Gene: PRPSAP1 phosphoribosyl pyrophosphate synthetase-associated protein 1".

Further reading

• Tatibana M, Kita K, Taira M, et al. (1995). "Mammalian phosphoribosyl-pyrophosphate synthetase". Adv. Enzyme Regul. 35: 229–49. doi:10.1016/0065-2571(94)00017-W. PMID   7572345.
• Kita K, Ishizuka T, Ishijima S, et al. (1994). "A novel 39-kDa phosphoribosylpyrophosphate synthetase-associated protein of rat liver. Cloning, high sequence similarity to the catalytic subunits, and a negative regulatory role". J. Biol. Chem. 269 (11): 8334–40. doi: 10.1016/S0021-9258(17)37198-3 . PMID   8132556.
• Ishizuka T, Kita K, Sonoda T, et al. (1996). "Cloning and sequencing of human complementary DNA for the phosphoribosylpyrophosphate synthetase-associated protein 39". Biochim. Biophys. Acta. 1306 (1): 27–30. doi:10.1016/0167-4781(96)00030-9. PMID   8611620.
• Ishijima S, Asai T, Kita K, et al. (1997). "Partial reconstitution of mammalian phosphoribosylpyrophosphate synthetase in Escherichia coli cells. Coexpression of catalytic subunits with the 39-kDa associated protein leads to formation of soluble multimeric complexes of various compositions". Biochim. Biophys. Acta. 1342 (1): 28–36. doi:10.1016/s0167-4838(97)00077-0. PMID   9366267.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.