Proline-rich protein 23C is a protein that in humans is encoded by the proline-rich 23C (PRR23C) gene.
PRR23C Homo sapiens is located on the long arm of chromosome 3, (3q23) on the antisense strand. [1] When pertaining to the mRNA of PRR23C Homo sapiens, it is 2,791 bp in length. [2] PRR23C Homo sapiens has one exon covering the entire length of mRNA (1-2,791 bp). [3] PRR23C Homo sapiens has a clone name of FLJ46210. [4]
PRR23C Homo sapiens is expressed in the testis. [5] Ottolini et al. (2014) discussed the PRR23 family to which they revealed that through RNA sequencing data, that PRR23A, PRR23B and PRR23C are testis-specific genes. [6] Ottolini et al. (2014) believes that this family may be a crucial part for the male reproductive system given their RNA-seq data findings. [7]
Proline-rich protein 23C Homo sapiens is 262 amino acids long [8] with a calculated molecular weight of 27,674 Da. [9] Proline-rich protein 23C Homo sapiens has a domain of unknown function (DUF2476) that spans the majority of the protein (1-259 aa) which is a conserved domain. [10] DUF2476 belongs to pfam10630 which is a part of superfamily c|11241. [11] DUF2476 is a family of proteins that are rich in proline residues and have unknown function. [12] Proline-rich protein 23C is the preferred name but other aliases include proline-rich protein 23A. [13]
Proline is predicted to be the most abundant amino acid in proline-rich protein 23C Homo sapiens. [14] In comparison to the prevalence of amino acids in other human proteins, it is predicted that proline-rich protein 23C Homo sapiens has a higher abundance of proline along with very low abundances of asparagine, threonine, and lysine. [15] Orthologs for this protein are predicted to also have a high abundance of proline. [16]
The basal isoelectric point for PRR23C Homo sapiens was 4.48 (pH) according to phoshosite.org. [17]
Proline-rich protein 23C is predicted to localize to the nucleus for the human protein and its orthologs. [18] There are predicted nuclear localization signals seen in both the human proline-rich protein 23C and its orthologs. [19]
PRR23C Homo sapiens is strictly conserved in mammals. [20] The table below lists mammalian orthologs for PRR23C Homo sapiens . [21]
| Genus & Species | Common Name | Accession Number [22] | Seq. Length [23] | Seq. Identity [24] | Seq. Similarity [25] |
|---|---|---|---|---|---|
| Homo sapiens | Human | NP_001128129.1 | 262 aa | 100% | 100% |
| Pan troglodytes | Chimpanzee | XP_003310067.1 | 263 aa | 98.50% | 98% |
| Gorilla gorilla gorilla | Western lowland gorilla | XP_004037787.1 | 263 aa | 96.60% | 98% |
| Pongo pygmaeus | Bornean orangutan | XP_002814147.1 | 263 aa | 94.70% | 95% |
| Nomascus leucogenys | Northern white-cheeked gibbon | XP_003265349.1 | 262 aa | 94.70% | 95% |
| Chlorocebus sabaeus | Green monkey | XP_008007123.1 | 263 aa | 92% | 94% |
| Rhinopithecus roxellana | Golden snub-nosed monkey | XP_010365056.1 | 263 aa | 91.60% | 93% |
| Papio anubis | Olive baboon | XP_003895087.1 | 263 aa | 94.70% | 93% |
| Callithrix jacchus | Common marmoset | XP_002759594.1 | 248 aa | 72.90% | 77% |
| Otolemur garnettii | Northern greater galago | XP_003789481.1 | 267 aa | 66.50% | 71% |
| Ceratotherium simum simum | White rhinoceros | XP_004419371.1 | 263 aa | 63.70% | 75% |
| Pteropus alecto | Black flying fox | XP_006907344.1 | 268 aa | 50.90% | 68% |
| Myotis lucifugus | Little brown bat | XP_006083994.1 | 257 aa | 61.20% | 64% |
| Bubalus bubalis | Water buffalo | XP_006070045.1 | 258 aa | 55.40% | 62% |
| Bison bison bison | American bison | XP_010856601.1 | 258 aa | 51.90% | 61% |
| Bos mutus | Yak | XP_005909007.1 | 258 aa | 51.50% | 61% |
| Lipotes vexillifer | Baiji | XP_007458979.1 | 260 aa | 51.50% | 64% |
| Tursiops truncatus | Common bottlenose dolphin | XP_004330081.1 | 261 aa | 54.50% | 61% |
| Balaenoptera acutorostrata scammoni | Minke whale | XP_007170446.1 | 255 aa | 53.60% | 61% |
| Physeter catodon | Sperm whale | XP_007117538.1 | 260 aa | 53.80% | 64% |
| Peromyscus maniculatus bairdii | Prairie deer mouse | XP_006975251.1 | 266 aa | 50.90% | 60% |
There were two paralogs found for PRR23C Homo sapiens: PRR23B and PRR23A. Both have similar sequence identities with PRR23B having 86% identity and PRR23A having 85% identity. [26]
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