PRR23C

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Proline-rich protein 23C is a protein that in humans is encoded by the proline-rich 23C (PRR23C) gene.

Contents

Gene

PRR23C Homo sapiens is located on the long arm of chromosome 3, (3q23) on the antisense strand. [1] When pertaining to the mRNA of PRR23C Homo sapiens, it is 2,791 bp in length. [2] PRR23C Homo sapiens has one exon covering the entire length of mRNA (1-2,791 bp). [3] PRR23C Homo sapiens has a clone name of FLJ46210. [4]

Expression

PRR23C Homo sapiens is expressed in the testis. [5] Ottolini et al. (2014) discussed the PRR23 family to which they revealed that through RNA sequencing data, that PRR23A, PRR23B and PRR23C are testis-specific genes. [6] Ottolini et al. (2014) believes that this family may be a crucial part for the male reproductive system given their RNA-seq data findings. [7]

Protein

Proline-rich protein 23C Homo sapiens is 262 amino acids long [8] with a calculated molecular weight of 27,674 Da. [9] Proline-rich protein 23C Homo sapiens has a domain of unknown function (DUF2476) that spans the majority of the protein (1-259 aa) which is a conserved domain. [10] DUF2476 belongs to pfam10630 which is a part of superfamily c|11241. [11] DUF2476 is a family of proteins that are rich in proline residues and have unknown function. [12] Proline-rich protein 23C is the preferred name but other aliases include proline-rich protein 23A. [13]

Protein composition

Proline is predicted to be the most abundant amino acid in proline-rich protein 23C Homo sapiens. [14] In comparison to the prevalence of amino acids in other human proteins, it is predicted that proline-rich protein 23C Homo sapiens has a higher abundance of proline along with very low abundances of asparagine, threonine, and lysine. [15] Orthologs for this protein are predicted to also have a high abundance of proline. [16]

Isoelectric point

The basal isoelectric point for PRR23C Homo sapiens was 4.48 (pH) according to phoshosite.org. [17]

Sub-cellular localization

Proline-rich protein 23C is predicted to localize to the nucleus for the human protein and its orthologs. [18] There are predicted nuclear localization signals seen in both the human proline-rich protein 23C and its orthologs. [19]

Homology

Orthologs

PRR23C Homo sapiens is strictly conserved in mammals. [20] The table below lists mammalian orthologs for PRR23C Homo sapiens . [21]

Genus & SpeciesCommon NameAccession Number [22] Seq. Length [23] Seq. Identity [24] Seq. Similarity [25]
Homo sapiens Human NP_001128129.1262 aa100%100%
Pan troglodytes Chimpanzee XP_003310067.1263 aa98.50%98%
Gorilla gorilla gorilla Western lowland gorilla XP_004037787.1263 aa96.60%98%
Pongo pygmaeus Bornean orangutan XP_002814147.1263 aa94.70%95%
Nomascus leucogenys Northern white-cheeked gibbon XP_003265349.1262 aa94.70%95%
Chlorocebus sabaeus Green monkey XP_008007123.1263 aa92%94%
Rhinopithecus roxellana Golden snub-nosed monkey XP_010365056.1263 aa91.60%93%
Papio anubis Olive baboon XP_003895087.1263 aa94.70%93%
Callithrix jacchus Common marmoset XP_002759594.1248 aa72.90%77%
Otolemur garnettii Northern greater galago XP_003789481.1267 aa66.50%71%
Ceratotherium simum simum White rhinoceros XP_004419371.1263 aa63.70%75%
Pteropus alecto Black flying fox XP_006907344.1268 aa50.90%68%
Myotis lucifugus Little brown bat XP_006083994.1257 aa61.20%64%
Bubalus bubalis Water buffalo XP_006070045.1258 aa55.40%62%
Bison bison bison American bison XP_010856601.1258 aa51.90%61%
Bos mutus Yak XP_005909007.1258 aa51.50%61%
Lipotes vexillifer Baiji XP_007458979.1260 aa51.50%64%
Tursiops truncatus Common bottlenose dolphin XP_004330081.1261 aa54.50%61%
Balaenoptera acutorostrata scammoni Minke whale XP_007170446.1255 aa53.60%61%
Physeter catodon Sperm whale XP_007117538.1260 aa53.80%64%
Peromyscus maniculatus bairdii Prairie deer mouse XP_006975251.1266 aa50.90%60%

Paralogs

There were two paralogs found for PRR23C Homo sapiens: PRR23B and PRR23A. Both have similar sequence identities with PRR23B having 86% identity and PRR23A having 85% identity. [26]

Related Research Articles

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References

  1. ↑ "Proline-rich protein 23C [Homo sapiens] - Protein - NCBI".
  2. ↑ "Homo sapiens proline rich 23C (PRR23C), mRNA". May 2019.{{cite journal}}: Cite journal requires |journal= (help)
  3. ↑ "Homo sapiens proline rich 23C (PRR23C), mRNA". May 2019.{{cite journal}}: Cite journal requires |journal= (help)
  4. ↑ "PRR23C proline rich 23C [Homo sapiens (human)] - Gene - NCBI".
  5. ↑ "EST Profile - Hs.531377".
  6. ↑ Ottolini, Barbara; Hornsby, Michael J.; Abujaber, Razan; MacArthur, Jacqueline A.L.; Badge, Richard M.; Schwarzacher, Trude; Albertson, Donna G.; Bevins, Charles L.; Solnick, Jay V.; Hollox, Edward J. (October 18, 2014). "Evidence of Convergent Evolution in Humans and Macaques Supports an Adaptive Role for Copy Number Variation of the b-Defensin-2 Gene". Genome Biology and Evolution. 6 (11): 3025–3038. doi:10.1093/gbe/evu236. PMC   4255768 . PMID   25349268.
  7. ↑ Ottolini, Barbara; Hornsby, Michael J.; Abujaber, Razan; MacArthur, Jacqueline A.L.; Badge, Richard M.; Schwarzacher, Trude; Albertson, Donna G.; Bevins, Charles L.; Solnick, Jay V.; Hollox, Edward J. (October 18, 2014). "Evidence of Convergent Evolution in Humans and Macaques Supports an Adaptive Role for Copy Number Variation of the b-Defensin-2 Gene". Genome Biology and Evolution. 6 (11): 3025–3038. doi:10.1093/gbe/evu236. PMC   4255768 . PMID   25349268.
  8. ↑ "Proline-rich protein 23C [Homo sapiens] - Protein - NCBI".
  9. ↑ "Proline-rich protein 23C [Homo sapiens] - Protein - NCBI".
  10. ↑ "Proline-rich protein 23C [Homo sapiens] - Protein - NCBI".
  11. ↑ "CDD Conserved Protein Domain Family: DUF2476".
  12. ↑ "CDD Conserved Protein Domain Family: DUF2476".
  13. ↑ "PRR23C proline rich 23C [Homo sapiens (human)] - Gene - NCBI".
  14. ↑ Protein Tools SAPS (Biology Workbench) http://workbench.sdsc.edu Volker Brendel, Department of Mathematics, Stanford University, Stanford CA 94305, U.S.A., modified; any errors are due to the modification.
  15. ↑ Protein Tools SAPS (Biology Workbench) http://workbench.sdsc.edu Volker Brendel, Department of Mathematics, Stanford University, Stanford CA 94305, U.S.A., modified; any errors are due to the modification.
  16. ↑ Protein Tools SAPS (Biology Workbench) http://workbench.sdsc.edu Volker Brendel, Department of Mathematics, Stanford University, Stanford CA 94305, U.S.A., modified; any errors are due to the modification.
  17. ↑ "PhosphoSitePlus". Archived from the original on 2019-04-03. Retrieved 2020-04-28.
  18. ↑ PSORTII http://www.genscript.com/psort/psort2.html
  19. ↑ PSORTII http://www.genscript.com/psort/psort2.html
  20. ↑ "Protein BLAST: Search protein databases using a protein query".
  21. ↑ "Protein BLAST: Search protein databases using a protein query".
  22. ↑ "Home - Protein - NCBI".
  23. ↑ "Protein BLAST: Search protein databases using a protein query".
  24. ↑ "Protein BLAST: Search protein databases using a protein query".
  25. ↑ "Protein BLAST: Search protein databases using a protein query".
  26. ↑ "Protein BLAST: Search protein databases using a protein query".
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