PRR4

PRR4
Identifiers
Aliases	PRR4 , LPRP, PROL4, proline rich 4 (lacrimal), proline rich 4
External IDs	OMIM: 605359; HomoloGene: 48512; GeneCards: PRR4; OMA:PRR4 - orthologs
Gene location (Human) Chr. Chromosome 12 (human) [1] Band 12p13.2 Start 10,845,849 bp [1] End 10,849,475 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in olfactory zone of nasal mucosa salivary gland minor salivary glands testicle skin of leg duodenum primary visual cortex C1 segment skin of abdomen substantia nigra n/a More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 11272 n/a Ensembl ENSG00000111215 ENSG00000282269 ENSG00000263247 n/a UniProt Q16378 n/a RefSeq (mRNA) NM_007244 NM_001098538 n/a RefSeq (protein) NP_001092008 NP_009175 n/a Location (UCSC) Chr 12: 10.85 – 10.85 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Proline-rich protein 4 is a protein that in humans is encoded by the PRR4 gene. ^{[3] [4]}

Lacrimal proline rich protein is a member of the proline-rich protein family which lacks a conserved repetitive domain. It may have a role in protective functions in the eye. ^[4]

References

1. ENSG00000282269, ENSG00000263247 GRCh38: Ensembl release 89: ENSG00000111215, ENSG00000282269, ENSG00000263247 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Dickinson DP, Thiesse M (Oct 1995). "A major human lacrimal gland mRNA encodes a new proline-rich protein family member". Invest Ophthalmol Vis Sci. 36 (10): 2020–31. PMID   7544782.
4. "Entrez Gene: PRR4 proline rich 4 (lacrimal)".

Further reading

• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.
• Fung KY, Morris C, Sathe S, et al. (2005). "Characterization of the in vivo forms of lacrimal-specific proline-rich proteins in human tear fluid". Proteomics. 4 (12): 3953–9. doi:10.1002/pmic.200300849. PMID   15526346. S2CID   42700978.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID   15146197. S2CID   27764390.
• Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID   12665801. S2CID   23783563.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.