PRSS23

PRSS23
Identifiers
Aliases	PRSS23 , SIG13, SPUVE, ZSIG13, protease, serine 23, serine protease 23
External IDs	OMIM: 618376 MGI: 1923703 HomoloGene: 5191 GeneCards: PRSS23
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11q14.2 Start 86,791,059 bp [1] End 86,952,910 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7|7 D3 Start 89,156,991 bp [2] End 89,176,395 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right coronary artery saphenous vein urethra bronchial epithelial cell trachea gallbladder smooth muscle tissue islet of Langerhans popliteal artery ascending aorta Top expressed in cervix conjunctival fornix seminal vesicula cornea calvaria submandibular gland Epithelium of stomach external carotid artery sternocleidomastoid muscle vastus lateralis muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptidase activity serine-type peptidase activity serine-type endopeptidase activity hydrolase activity Cellular component extracellular region extracellular exosome nucleus extracellular space endoplasmic reticulum lumen Biological process proteolysis post-translational protein modification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11098 76453 Ensembl ENSG00000150687 ENSMUSG00000039405 UniProt O95084 Q9D6X6 RefSeq (mRNA) NM_001293178 NM_001293179 NM_001293180 NM_007173 NM_029614 NM_001360752 NM_001360753 NM_001360754 NM_001360755 NM_001360756 NM_001384148 NM_001384151 RefSeq (protein) NP_001280108 NP_001280109 NP_009104 NP_083890 NP_001347681 NP_001347682 NP_001347683 NP_001347684 NP_001347685 NP_001371077 NP_001371080 Location (UCSC) Chr 11: 86.79 – 86.95 Mb Chr 7: 89.16 – 89.18 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Serine protease 23 is an enzyme that in humans is encoded by the PRSS23 gene. ^[5]

This gene encodes a member of the trypsin family of serine proteases. Mouse studies found a decrease of mRNA levels after ovulation was induced. This gene seems to be highly conserved in vertebrates and may be an important ovarian protease. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000150687 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000039405 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: PRSS23 protease, serine, 23".

Further reading

• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–1795. doi:10.1101/gr.143000. PMC   310948 . PMID   11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–435. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–292. doi:10.1093/embo-reports/kvd058. PMC   1083732 . PMID   11256614.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Imabayashi H, Mori T, Gojo S, et al. (2003). "Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis". Exp. Cell Res. 288 (1): 35–50. doi:10.1016/S0014-4827(03)00130-7. PMID   12878157.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–2270. doi:10.1101/gr.1293003. PMC   403697 . PMID   12975309.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–2144. doi:10.1101/gr.2576704. PMC   528930 . PMID   15489336.
• Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–968. doi:10.1016/j.cell.2005.08.029. hdl: 11858/00-001M-0000-0010-8592-0 . PMID   16169070. S2CID   8235923.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–126. doi: 10.1093/dnares/12.2.117 . PMID   16303743.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–D418. doi:10.1093/nar/gkj139. PMC   1347501 . PMID   16381901.
• Miyakoshi K, Murphy MJ, Yeoman RR, et al. (2007). "The identification of novel ovarian proteases through the use of genomic and bioinformatic methodologies". Biol. Reprod. 75 (6): 823–835. doi: 10.1095/biolreprod.106.052290 . PMID   16870946.