PSB-KK1415

PSB-KK1415
Identifiers
	IUPAC name 7-[(4-chlorophenyl)methyl]-8-[2-(1H-indol-3-yl)ethylamino]-1,3-dimethylpurine-2,6-dione;
CAS Number	885896-26-4 ;
PubChem CID	4874764 ;
Chemical and physical data
Formula	C24H23ClN6O2
Molar mass	462.94 g·mol−1
3D model (JSmol)	Interactive image ;
	SMILES CN1C2=C(C(=O)N(C1=O)C)N(C(=N2)NCCC3=CNC4=CC=CC=C43)CC5=CC=C(C=C5)Cl;
	InChI InChI=1S/C24H23ClN6O2/c1-29-21-20(22(32)30(2)24(29)33)31(14-15-7-9-17(25)10-8-15)23(28-21)26-12-11-16-13-27-19-6-4-3-5-18(16)19/h3-10,13,27H,11-12,14H2,1-2H3,(H,26,28); Key:FHFDQEPXKZVEOI-UHFFFAOYSA-N;

Last updated April 25, 2025

PSB-KK1415 is an experimental drug that acts as a potent and selective agonist for the cannabinoid-like NAGly receptor, also known as GPR18. It has potential applications in studying the immune system and development of cancer.^[1]

References

↑ Mahardhika AB, Załuski M, Schoeder CT, Boshta NM, Schabikowski J, Perri F, et al. (June 2024). "Potent, Selective Agonists for the Cannabinoid-like Orphan G Protein-Coupled Receptor GPR18: A Promising Drug Target for Cancer and Immunity". Journal of Medicinal Chemistry. 67 (12): 9896–9926. doi:10.1021/acs.jmedchem.3c02423. PMID 38885438.

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[1] Mahardhika AB, Załuski M, Schoeder CT, Boshta NM, Schabikowski J, Perri F, et al. (June 2024). "Potent, Selective Agonists for the Cannabinoid-like Orphan G Protein-Coupled Receptor GPR18: A Promising Drug Target for Cancer and Immunity". Journal of Medicinal Chemistry. 67 (12): 9896–9926. doi:10.1021/acs.jmedchem.3c02423. PMID 38885438.

[1]

Identifiers

IUPAC name 7-[(4-chlorophenyl)methyl]-8-[2-(1H-indol-3-yl)ethylamino]-1,3-dimethylpurine-2,6-dione
CAS Number	885896-26-4
PubChem CID	4874764
Chemical and physical data
Formula	C₂₄H₂₃ClN₆O₂
Molar mass	462.94 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CN1C2=C(C(=O)N(C1=O)C)N(C(=N2)NCCC3=CNC4=CC=CC=C43)CC5=CC=C(C=C5)Cl
InChI InChI=1S/C24H23ClN6O2/c1-29-21-20(22(32)30(2)24(29)33)31(14-15-7-9-17(25)10-8-15)23(28-21)26-12-11-16-13-27-19-6-4-3-5-18(16)19/h3-10,13,27H,11-12,14H2,1-2H3,(H,26,28) Key:FHFDQEPXKZVEOI-UHFFFAOYSA-N