Patrick Harran (born 13 July 1969) is an American organic chemist who has held the D. J. & J. M. Cram Chair in Organic Chemistry, an endowed chair at the University of California, Los Angeles, since 2008. Prior to taking this position he was a professor at the University of Texas Southwestern Medical Center. [1] Harran was educated at Skidmore College graduating in 1990. He went on to Yale University, where he was awarded a Ph.D. in 1995. [2]
In 2009, a research assistant in his lab, Sheri Sangji, died from burn injuries after a chemical fire. [3] A California Division of Occupational Safety and Health report faulted Harran for willfully neglecting safety protocols. [4] He was charged with four felony counts in the first criminal case stemming from a laboratory accident in U.S. history, but avoided jailtime through a plea deal with prosecutors, which was finalized in 2018. [5] [6] In 2015, the AAAS Chemistry Section nominated, but then did not proceed with the nomination of Harran for AAAS Fellow, after concerns about the Sangji case were raised by the ACS Committee on Chemical Safety. [7]
Harran's research is focused on the total synthesis of natural products, design of novel chemical compounds to study protein–protein interactions, and medicinal chemistry. [8]
On December 29, 2008, a fire in Harran's UCLA laboratory fatally burned research assistant Sheri Sangji. Harran in 2011 was charged with four felony counts of willfully violating occupational safety standards in the case, carrying a maximum jail term of 4.5 years. It was the first time any American academic had been criminally charged for a laboratory accident. Representatives of Harran, and the university's Board of Regents who were also charged in the incident, disputed the charges. [12] [13]
Harran and prosecutors in 2014 reached a deferred prosecution agreement in which Harran was ordered to pay $10,000 to a local burn center and do 800 hours of community service. [12] [14] Deputy District Attorney Craig W. Hum said that the penalty was similar to any sentence Harran would have received if convicted, while Sangji's family criticized it as "barely a slap on the wrist". [14] The charges were subsequently dropped in 2018, in accordance with the settlement terms. [15]
Paul Delos Boyer was an American biochemist, analytical chemist, and a professor of chemistry at University of California Los Angeles (UCLA). He shared the 1997 Nobel Prize in Chemistry for research on the "enzymatic mechanism underlying the biosynthesis of adenosine triphosphate (ATP)" with John E. Walker, making Boyer the first Utah-born Nobel laureate; the remainder of the Prize in that year was awarded to Danish chemist Jens Christian Skou for his discovery of the Na+/K+-ATPase.
Jacqueline K. Barton, is an American chemist. She worked as a Professor of Chemistry at Hunter College (1980–82), and at Columbia University (1983–89) before joining the California Institute of Technology. In 1997 she became the Arthur and Marian Hanisch Memorial Professor of Chemistry and from 2009 to 2019, the Norman Davidson Leadership Chair of the Division of Chemistry and Chemical Engineering at Caltech. She currently is the John G. Kirkwood and Arthur A. Noyes Professor of Chemistry.
Paul S. Weiss is a leading American nanoscientist at the University of California, Los Angeles. He holds numerous positions, including UC Presidential Chair, Distinguished Professor of Chemistry and Biochemistry, Bioengineering, and of Materials Science and Engineering, and founder and editor-in-chief of ACS Nano. From 2019–2014, he held the Fred Kavli Chair in NanoSystems Sciences and was the director of the California NanoSystems Institute. Weiss has co-authored over 400 research publications and holds over 40 US and international patents.
Armand Paul Alivisatos is an American chemist who serves as the 14th president of the University of Chicago. He is a pioneer in nanomaterials development and an authority on the fabrication of nanocrystals and their use in biomedical and renewable energy applications. He was ranked fifth among the world's top 100 chemists for the period 2000–2010 in the list released by Thomson Reuters.
John Radford Froines was an American chemist and anti-war activist, noted as a member of the Chicago Seven, a group charged with involvement with the riots at the 1968 Democratic National Convention in Chicago. Froines, who held a Ph.D. in chemistry from Yale, was charged with interstate travel for purposes of inciting a riot and with making incendiary devices, but was acquitted. He later served as the Director of Toxic Substances at the federal Occupational Safety and Health Administration and then director of UCLA’s Occupational Health Center. He also served as chair of the California Scientific Review Panel on Toxic Air Contaminants for nearly 30 years before resigning in 2013 amid controversy and claims of conflict of interest.
Sir James Fraser Stoddart is a British-American chemist who is Board of Trustees Professor of Chemistry and head of the Stoddart Mechanostereochemistry Group in the Department of Chemistry at Northwestern University in the United States. He works in the area of supramolecular chemistry and nanotechnology. Stoddart has developed highly efficient syntheses of mechanically-interlocked molecular architectures such as molecular Borromean rings, catenanes and rotaxanes utilising molecular recognition and molecular self-assembly processes. He has demonstrated that these topologies can be employed as molecular switches. His group has even applied these structures in the fabrication of nanoelectronic devices and nanoelectromechanical systems (NEMS). His efforts have been recognized by numerous awards including the 2007 King Faisal International Prize in Science. He shared the Nobel Prize in Chemistry together with Ben Feringa and Jean-Pierre Sauvage in 2016 for the design and synthesis of molecular machines.
tert-Butyllithium is a chemical compound with the formula (CH3)3CLi. As an organolithium compound, it has applications in organic synthesis since it is a strong base, capable of deprotonating many carbon molecules, including benzene. tert-Butyllithium is available commercially as hydrocarbon solutions; it is not usually prepared in the laboratory.
Kendall Newcomb Houk is a Distinguished Research Professor in Organic Chemistry at the University of California, Los Angeles. His research group studies organic, organometallic, and biological reactions using the tools of computational chemistry. This work involves quantum mechanical calculations, often with density functional theory, and molecular dynamics, either quantum dynamics for small systems or force fields such as AMBER, for solution and protein simulations.
Tobin Jay Marks is the Vladimir N. Ipatieff Professor of Catalytic Chemistry, Professor of Material Science and Engineering, Professor of Chemical and Biological Engineering, and Professor of Applied Physics at Northwestern University in Evanston, Illinois. Among the themes of his research are synthetic organo-f-element and early-transition metal organometallic chemistry, polymer chemistry, materials chemistry, homogeneous and heterogeneous catalysis, molecule-based photonic materials, superconductivity, metal-organic chemical vapor deposition, and biological aspects of transition metal chemistry.
Richard B. Kaner is an American synthetic inorganic chemist. He is a distinguished professor and the Dr. Myung Ki Hong Endowed Chair in Materials Innovation at the University of California, Los Angeles, where he holds a joint appointment in the Department of Chemistry and Biochemistry and the Department of Material Science and Engineering. Kaner conducts research on conductive polymers (polyaniline), superhard materials and carbon compounds, such as fullerenes and graphene.
James C. Liao is the Parsons Foundation Professor and Chair of the Department of Chemical and Biomolecular Engineering at the University of California, Los Angeles and is the co-founder and lead scientific advisor of Easel Biotechnologies, LLC.
The Sheri Sangji case is the first criminal case resulting from an academic laboratory accident.
Neil K. Garg is currently a Distinguished professor of chemistry and holds the Kenneth N. Trueblood Endowed Chair at the University of California, Los Angeles. Garg's research is focused on the chemical synthesis of organic compounds, with an emphasis on the development of new strategies for the preparation of complex molecules possessing unique structural, biological, and physical properties. His group has made breakthroughs in catalysis, especially strong bond activation of esters and amides using nickel catalysts, and in the understanding and utilization of strained intermediates, such as arynes, cyclic alkynes, and cyclic allenes. His laboratory has completed the total syntheses of many natural products, including welwitindolinones, akuammilines, and tubingensin alkaloids. Garg is a co-Founder of ElectraTect, Inc.,
Miguel A. García-Garibay is a professor of chemistry and biochemistry and the dean of physical sciences at University of California, Los Angeles (UCLA). His research focuses on solid state organic chemistry, photochemistry and spectroscopy, artificial molecular machines, and mesoscale phenomena.
Abigail Gutmann Doyle is a Professor of Chemistry at the University of California, Los Angeles, where she holds the Saul Winstein Chair in Organic Chemistry. Her research focuses on the development of new chemical transformations in organic chemistry.
Nancy Lynne Wayne is an American physiologist, academic administrator, and researcher. She is professor of physiology at the David Geffen School of Medicine at UCLA, where she has been the principal investigator of a reproductive physiology lab, publishing research on the impact of environment signals and endocrine-disruptors on the reproductive system. She has also carried out notable work on sexism, professional development, and laboratory safety.
Robin L. Garrell is an American chemist, academic and current President of The Graduate Center, CUNY. Until 2020, Garrell served as Vice Provost for Graduate Education and Dean of Graduate Division at University of California, Los Angeles (UCLA). Prior to this role, Garrell was assistant professor at the University of Pittsburgh from 1984 to 1991, then joined the faculty in the Department of Chemistry and Biochemistry at UCLA, where she became full professor and held a joint appointment in Bioengineering. Garrell assumed her current position at The Graduate Center on August 1, 2020.
Jessica R. Kramer is an American biomedical engineer working as an Assistant Professor of Bio-engineering and Adjunct Assistant Professor of Pharmaceutics and Pharmaceutical Chemistry at the University of Utah. Kramer’s research lab focuses on the synthesis and application of glycopolypeptides.
Anastassia N. Alexandrova is an American chemist who is a professor at the University of California, Los Angeles. Her research considers the computational design of functional materials.
Yi Tang is a biochemist and professor in the Department of Chemistry and Biochemistry and the Department of Chemical and Biomolecular Engineering at the University of California, Los Angeles. His research interests include the discovery, functional characterization, and engineering of natural product biosynthetic enzymes. He was awarded the 2014 Eli Lilly Award in Biological Chemistry.