Paul Shattock

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Paul Shattock OBE is a British autism researcher and scientific consultant to the charity Education and Services for People with Autism, of which he is also the founder. [1] He was formerly the director of the Autism Research Unit at the University of Sunderland. He is well known for his disputed research into dietary therapy and autism, having claimed that autistic children may have a "leaky gut" which allows certain peptides to enter the bloodstream, and claimed that they excrete unusually high levels thereof. As a result of this speculation, he has promoted the use of a gluten-free, casein-free diet to ameliorate the symptoms of autism, a theory he developed along with Kalle Reichelt. In addition, he has claimed that a protein found in milk may play a role in the etiology of autism. [2] He is also the former president of the World Autism Organization.

In 2002, Shattock conducted a survey and claimed that this survey had identified a unique subset of autistic children who may be uniquely susceptible to the MMR vaccine. These children were identified by the fact that they tended to suffer from bowel problems, had an abnormal gait and were friendlier than other autistic children. [3] In addition, this survey concluded that one in ten parents of autistic children attributed their child's autism to this vaccine, and that these children had much higher levels of urinary indolyl-3-acryloylglycine. [4] [5] However, Shattock was criticized by Peter Dukes of the Medical Research Council, who noted that Shattock's findings had yet to be published in a peer-reviewed journal. [6]

Personal life

Shattock has a son, Jamie, who was diagnosed with autism in 1975. [7]

In 1980 Shattock helped raise £80,000 to pay for the North East Autism Society (NEAS) centre at Thornhill Park, when he was known as "the Birdman". [8] [9]

Related Research Articles

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Indolyl-3-acryloylglycine, also known as trans-indolyl-3-acryloylglycine, or IAG for short, is a compound consisting of an indole group attached to an acrylic acid moiety, which is in turn attached to a glycine molecule. This compound has been shown to isomerize when exposed to light. It is likely a metabolic intermediate in the biosynthesis of tryptophan, and is synthesized from tryptophan via indolepropionic acid and indoleacrylicacid (IAcrA). It is also likely that IAcrA is converted into IAG in the gut wall. It may also be produced by certain elements of the mammalian gut microbiota by phenylalanine ammonia-lyase. Identifiable in the urine by high-performance liquid chromatography, it may be a biomarker for autism spectrum disorders, as demonstrated by the research of Paul Shattock and other researchers from Australia. These researchers have reported that urinary levels of IAG are much higher in autistic children than in controls; however, other researchers have found no association between IAG concentrations in the urine and autism. Its excretion in the urine may also be changed in Hartnup disease and celiac disease, as well as photodermatosis, muscular dystrophy, and liver cirrhosis.

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References

  1. Nelson, Barry (4 February 2010). "Consultant to the Espa Autism Research Unit". The Northern Echo . Retrieved 9 June 2017.
  2. "The World Today - Autism, milk link played down". Abc.net.au. 2002-11-13. Retrieved 2013-10-10.
  3. Derbyshire, David (2002-06-28). "MMR 'may be linked to certain type of autism'". Telegraph. Retrieved 2013-10-10.
  4. Anderson, R. J.; Bendell, D. J.; Garnett, I.; Groundwater, P. W.; Lough, W. J.; Mills, M. J.; Savery, D.; Shattock, P. E. G. (2002). "Identification of indolyl-3-acryloylglycine in the urine of people with autism". Journal of Pharmacy and Pharmacology. 54 (2): 295–298. doi: 10.1211/0022357021778349 . PMID   11858215. S2CID   24999913.
  5. Fitzpatrick, Michael (17 July 2007). "The dark art of the MMR-autism panic". Spiked . Retrieved 30 January 2014.
  6. Meikle, James (28 June 2002). "MMR 'may cause 1 in 10 cases of autism'". The Guardian . Retrieved 10 October 2013.
  7. Shattock, Paul; Todd, Linda. "Sunderland University & The Autism Research Unit: The Early Years". Autismfile.com. Archived from the original on 25 September 2017. Retrieved 10 October 2013.
  8. "Sunderland's own Flying Squirrel urges city to back new appeal to help school for autistic pupils".
  9. "'Sunderland led the way to help autistic people' - says city's Birdman flying contest winner".