Phenamidine

Last updated
Phenamidine
Phenamidine.svg
Clinical data
Trade names Oxopirvedine
Other names4,4'-Diamidinodiphenyl ether; 4,4'-Oxydibenzamidine
ATCvet code
Identifiers
  • 4,4’-Oxydibenzenecarboximidamide
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
ECHA InfoCard 100.002.692 OOjs UI icon edit-ltr-progressive.svg
Chemical and physical data
Formula C14H14N4O
Molar mass 254.293 g·mol−1
3D model (JSmol)
Melting point 215 to 216 °C (419 to 421 °F) [1]
  • O(c1ccc(C(=[N@H])N)cc1)c2ccc(cc2)C(=[N@H])N
  • InChI=1S/C14H14N4O/c15-13(16)9-1-5-11(6-2-9)19-12-7-3-10(4-8-12)14(17)18/h1-8H,(H3,15,16)(H3,17,18)
  • Key:DMABBVCVVXMJDH-UHFFFAOYSA-N

Phenamidine is an antiprotozoal drug of the amidine class used in veterinary medicine. It is used to treat Babesia infection (babesiosis) dogs, horses, and cattle. [1] [2] Because the drug causes frequent allergic reactions, it is usually combined with an antihistamine. [3]

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Premunition, also known as infection-immunity, is a host response that protects against high numbers of parasite and illness without eliminating the infection. This type of immunity is relatively rapid, progressively acquired, short-lived, and partially effective. For malaria, premunition is maintained by repeated antigen exposure from infective bites. Thus, if an individual departs from an endemic area, he or she may lose premunition and become susceptible to malaria.

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References

  1. 1 2 Merck Index , 11th Edition, 7165
  2. Randall JB, Laws SG (May 1947). "Phenamidine in the treatment of Babesia bigemina infections of cattle". Annals of Tropical Medicine and Parasitology. 41 (1): 39–42. doi:10.1080/00034983.1947.11685310. PMID   20249289.
  3. Benchchem