Philip George Houthem Gell

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Philip George Houthem Gell (20 October 1914 – 3 May 2001) [1] was a British immunologist working in postwar Britain. [2]

Together with Robin Coombs, he developed the Gell–Coombs classification of hypersensitivity. He was elected Fellow of the Royal Society in 1969. [1]

Robin Coombs immunologist

Robert Royston Amos Coombs FRS FRCPath FRCP was a British immunologist, co-discoverer of the Coombs test (1945) used for detecting antibodies in various clinical scenarios, such as Rh disease and blood transfusion.

Hypersensitivity refers to undesirable reactions produced by the normal immune system, including allergies and autoimmunity. They are usually referred to as an over-reaction of the immune system and these reactions may be damaging, uncomfortable, or occasionally fatal. Hypersensitivity reactions require a pre-sensitized (immune) state of the host. They are classified in four groups after the proposal of P. G. H. Gell and Robin Coombs in 1963.

Fellow of the Royal Society Elected Fellow of the Royal Society, including Honorary, Foreign and Royal Fellows

Fellowship of the Royal Society is an award granted to individuals that the Royal Society of London judges to have made a 'substantial contribution to the improvement of natural knowledge, including mathematics, engineering science, and medical science'.

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Philip Gell may refer to:

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Type II hypersensitivity, in the Gell and Coombs classification of allergic reactions, is an antibody mediated process in which IgG and IgM antibodies are directed against antigens on cells or extracellular material. This subsequently leads to cell lysis, tissue damage or loss of function through mechanisms such as 1. complement activation via the classical complement pathway 2. antibody dependent cell-mediated cytotoxicity or 3. anti-receptor activity. The activation of the the complement system results in opsonization, the agglutination of red blood cells, cell lysis, and cell death.

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The following is a list of notable deaths in September 2001.

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References

  1. 1 2 Silverstein, Arthur M. "PHILIP GEORGE HOUTHEM GELL". Royal Society#Publishing . Retrieved 2019-01-26.
  2. Hopkins, John (2001-05-22). "Philip Gell". The Guardian . Retrieved 2019-01-26.