Phospholipase A-2-activating protein

PLAA
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2K89, 2K8A, 2K8B, 2K8C, 3EBB
Identifiers
Aliases	PLAA , DOA1, PLA2P, PLAP, phospholipase A2 activating protein, NDMSBA
External IDs	OMIM: 603873; MGI: 104810; HomoloGene: 3138; GeneCards: PLAA; OMA:PLAA - orthologs
Gene location (Human) Chr. Chromosome 9 (human) [1] Band 9p21.2 Start 26,903,372 bp [1] End 26,947,242 bp [1]
Gene location (Mouse) Chr. Chromosome 4 (mouse) [2] Band 4 C5|4 43.34 cM Start 94,455,751 bp [2] End 94,491,481 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastrocnemius muscle secondary oocyte stromal cell of endometrium muscle of thigh testicle ganglionic eminence monocyte ventricular zone gonad Achilles tendon Top expressed in tail of embryo genital tubercle zygote secondary oocyte epiblast medial ganglionic eminence Gonadal ridge mandibular prominence primitive streak somite More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding phospholipase A2 activator activity ubiquitin binding Cellular component extracellular exosome cytoplasm nucleus synapse cell junction Biological process phospholipid metabolic process inflammatory response signal transduction ubiquitin recycling proteasome-mediated ubiquitin-dependent protein catabolic process macroautophagy ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway cellular response to lipopolysaccharide negative regulation of protein K63-linked ubiquitination positive regulation of synaptic vesicle recycling positive regulation of dendrite extension positive regulation of neuron migration prostaglandin metabolic process multicellular organism development nervous system development positive regulation of phospholipase A2 activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9373 18786 Ensembl ENSG00000137055 ENSMUSG00000028577 UniProt Q9Y263 P27612 RefSeq (mRNA) NM_001031689 NM_004253 NM_001321546 NM_172695 RefSeq (protein) NP_001026859 NP_001308475 NP_766283 Location (UCSC) Chr 9: 26.9 – 26.95 Mb Chr 4: 94.46 – 94.49 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Phospholipase A-2-activating protein is an enzyme that in humans is encoded by the PLAA gene. ^{[5] [6] [7]}

References

1. GRCh38: Ensembl release 89: ENSG00000137055 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028577 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Chopra AK, Ribardo DA, Wood TG, Prusak DJ, Xu XJ, Peterson JW (Mar 1999). "Molecular characterization of cDNA for phospholipase A2-activating protein". Biochim Biophys Acta. 1444 (1): 125–30. doi:10.1016/s0167-4781(98)00249-8. PMID   9931468.
6. Beatty BG, Qi S, Pienkowska M, Herbrick JA, Scheidl T, Zhang ZM, Kola I, Scherer SW, Seth A (Mar 2000). "Chromosomal localization of phospholipase A2 activating protein, an Ets2 target gene, to 9p21". Genomics. 62 (3): 529–32. doi:10.1006/geno.1999.5999. PMID   10644453.
7. "Entrez Gene: PLAA phospholipase A2-activating protein".

4. Cooper B, Bomalaski JS. Activation of mechanonociceptors by pro-inflammatory peptides melittin and PLAP peptide. Exp Brain Res. 1994;100:18–28. doi: 10.1007/BF00227275. https://link.springer.com/article/10.1007/BF00227275

Further reading

• Clark MA, Ozgür LE, Conway TM, et al. (1991). "Cloning of a phospholipase A2-activating protein". Proc. Natl. Acad. Sci. U.S.A. 88 (12): 5418–22. Bibcode:1991PNAS...88.5418C. doi: 10.1073/pnas.88.12.5418 . PMC   51884 . PMID   2052621.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Ruiz A, Nadal M, Puig S, Estivill X (1999). "Cloning of the human phospholipase A2 activating protein (hPLAP) gene on the chromosome 9p21 melanoma deleted region". Gene. 239 (1): 155–61. doi:10.1016/S0378-1119(99)00354-6. PMID   10571045.
• Seigneurin-Berny D, Verdel A, Curtet S, et al. (2001). "Identification of components of the murine histone deacetylase 6 complex: link between acetylation and ubiquitination signaling pathways". Mol. Cell. Biol. 21 (23): 8035–44. doi:10.1128/MCB.21.23.8035-8044.2001. PMC   99970 . PMID   11689694.
• Kozlenkov A, Manes T, Hoylaerts MF, Millán JL (2002). "Function assignment to conserved residues in mammalian alkaline phosphatases". J. Biol. Chem. 277 (25): 22992–9. doi: 10.1074/jbc.M202298200 . PMID   11937510.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Koumanov K, Momchilova A, Wolf C (2004). "Bimodal regulatory effect of melittin and phospholipase A2-activating protein on human type II secretory phospholipase A2". Cell Biol. Int. 27 (10): 871–7. doi:10.1016/S1065-6995(03)00176-8. PMID   14499668. S2CID   10953531.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC   2734081 . PMID   15164053.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.