Pinc

Last updated
Pregnancy induced noncoding RNA
Identifiers
Organism mouse
SymbolPinc
Entrez 723792
RefSeq (mRNA) NR_003202
Other data
Chromosome 1: 73.44 - 73.45 Mb

Pinc (pregnancy induced noncoding RNA) is a long non-coding RNA. It was originally identified in the mammary glands of oestrogen and progesterone-treated rats. [1] Pinc may be a mammal-specific gene. It is conserved in a number of mammalian genomes (human, mouse, rat, chimpanzee, dog, cow and opossum), but not in fugu, zebrafish or xenopus genomes. [2]

Contents

In mice, Pinc is expressed in the developing embryo and in the mammary glands of adults. Its expression in the mammary gland is induced by pregnancy and drops during lactation. It may have a role in cell survival and in the regulation of cell cycle progression. [2]

See also

References

  1. ↑ Ginger MR, Gonzalez-Rimbau MF, Gay JP, Rosen JM (November 2001). "Persistent changes in gene expression induced by estrogen and progesterone in the rat mammary gland". Mol. Endocrinol. 15 (11): 1993–2009. doi: 10.1210/mend.15.11.0724 . PMID   11682629.
  2. 1 2 Ginger MR, Shore AN, Contreras A, et al. (April 2006). "A noncoding RNA is a potential marker of cell fate during mammary gland development". Proc. Natl. Acad. Sci. U.S.A. 103 (15): 5781–5786. Bibcode:2006PNAS..103.5781G. doi: 10.1073/pnas.0600745103 . PMC   1420634 . PMID   16574773.

Further reading

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