Polly Fordyce

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Polly Fordyce
Born
Washington, DC, USA
Alma mater University of Colorado Boulder, BS
Stanford University, PhD
Known forHigh-throughput enzymology, biophysics, microfludiics
Awards Eli Lilly Award in Biological Chemistry
National Science Foundation CAREER Award
Fellow of the American Association for the Advancement of Science
Scientific career
FieldsBioengineering
Institutions Stanford University
Doctoral advisor Steven Block
Other academic advisors Joseph DeRisi
Website www.fordycelab.com

Polly Fordyce is an Associate Professor of Genetics and Bioengineering and fellow of the ChEM-H Institute at Stanford University. [1] Her laboratory's research focuses on developing and applying new microfluidic platforms for quantitative, high-throughput biophysics and biochemistry and single-cell genomics.

Contents

Fordyce was born and raised in Washington, DC. [2]

Education

Fordyce double-majored in physics and biology at the University of Colorado Boulder, graduating in 2000. She then began a PhD in the lab of Steven Block at Stanford University, where she worked as part of a team that developed new microscopes for applying force to molecules and understanding how it affected their movements. [3] After receiving her PhD in 2007, she moved to UCSF to pursue postdoctoral research in Joseph DeRisi's laboratory developing high-throughput methods for the analysis of transcription factor interactions. [4] She has been a professor at Stanford since 2014. [2]

Research

Fordyce's lab develops approaches for high throughput quantitative biochemistry, biophysics, and single cell assays, using a variety of approaches including microfluidics. [5] One of her lab's accomplishments is the development of the method HT-MEK (High-Throughput Microfluidic Enzyme Kinetics), [6] which enables researchers to analyze the effects of thousands of mutations on an enzyme's activity in a single experiment. [7]

Awards

References

  1. ↑ "Polly Fordyce - Stanford Medicine Profiles". med.stanford.edu.
  2. 1 2 "The beadnik: Polly Fordyce uses something tiny to do something big". med.stanford.edu.
  3. ↑ Lang MJ, Fordyce PM, Engh AM, Neuman KC, Block SM (November 2004). "Simultaneous, coincident optical trapping and single-molecule fluorescence". Nature Methods. 1 (2): 133–139. doi:10.1038/nmeth714. PMC   1483847 . PMID   15782176.
  4. ↑ Fordyce PM, Gerber D, Tran D, Zheng J, Li H, DeRisi JL, Quake SR (September 2010). "De novo identification and biophysical characterization of transcription-factor binding sites with microfluidic affinity analysis". Nature Biotechnology. 28 (9): 970–975. doi:10.1038/nbt.1675. PMC   2937095 . PMID   20802496.
  5. ↑ "The Fordyce Lab".
  6. ↑ Markin CJ, Mokhtari DA, Sunden F, Appel MJ, Akiva E, Longwell SA, et al. (July 2021). "Revealing enzyme functional architecture via high-throughput microfluidic enzyme kinetics". Science. 373 (6553) eabf8761. doi:10.1126/science.abf8761. PMC   8454890 . PMID   34437092.
  7. ↑ Reardon S (July 2021). "Single chip tests thousands of enzyme mutations at once". Nature. doi:10.1038/d41586-021-02034-3. PMID   34302155. S2CID   236210249.
  8. ↑ "Five Stanford faculty receive NSF CAREER Award". 2 February 2022.
  9. ↑ "Professor Polly Fordyce – Division of Biological Chemistry" . Retrieved 2023-01-06.
  10. ↑ "2024 AAAS Fellows" . Retrieved 2025-03-28.
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