Povl Krogsgaard-Larsen

Povl Krogsgaard-Larsen
Born	(1941-05-17) May 17, 1941 (age 83) Frøslev, Denmark
Occupation	Medicinal chemist
Years active	1972–present
Organization	University of Copenhagen
Known for	AMPA; THIP; Others
Website	https://drug.ku.dk/staff/?pure=en/persons/94758 https://researchprofiles.ku.dk/en/persons/povl-krogsgaard-larsen

Povl Krogsgaard-Larsen (born May 17, 1941) is a Danish medicinal chemist who studies the glutamatergic, GABAergic, and cholinergic neurotransmitter systems and drugs acting on these systems. ^{[1] [2] [3] [4] [5]} He is known for discovering and developing the AMPA receptor agonist AMPA and the Amanita muscaria - or muscimol-derived GABA_A receptor agonist THIP (gaboxadol), among many other scientific contributions. ^{[2] [1] [3] [4] [5]} Some other notable drugs he has developed include the GABA_A receptor agonist isoguvacine and the GABA reuptake inhibitors nipecotic acid and guvacine (which led to the subsequent independent development of tiagabine). ^[5] Krogsgaard-Larsen is considered to be a giant in the field of medicinal chemistry and to be the most impactful Danish medicinal chemist. ^[1] An autobiography for Krogsgaard-Larsen was published in 2011. ^[1]

Selected publications

• Krogsgaard-Larsen P, Johnston GA (December 1975). "Inhibition of GABA uptake in rat brain slices by nipecotic acid, various isoxazoles and related compounds". J Neurochem. 25 (6): 797–802. doi:10.1111/j.1471-4159.1975.tb04410.x. PMID   1206398.
• Krogsgaard-Larsen P, Johnston GA, Curtis DR, Game CJ, McCulloch RM (December 1975). "Structure and biological activity of a series of conformationally restricted analogues of GABA". J Neurochem. 25 (6): 803–809. doi:10.1111/j.1471-4159.1975.tb04411.x. PMID   1206399.
• Krogsgaard-Larsen P, Johnston GA, Lodge D, Curtis DR (July 1977). "A new class of GABA agonist". Nature. 268 (5615): 53–55. doi:10.1038/268053a0. PMID   196200.
• Krogsgaard-Larsen P, Honoré T, Hansen JJ, Curtis DR, Lodge D (March 1980). "New class of glutamate agonist structurally related to ibotenic acid". Nature. 284 (5751): 64–66. doi:10.1038/284064a0. PMID   6101908.
• Honoré T, Lauridsen J, Krogsgaard-Larsen P (January 1982). "The binding of [3H]AMPA, a structural analogue of glutamic acid, to rat brain membranes". J Neurochem. 38 (1): 173–178. doi:10.1111/j.1471-4159.1982.tb10868.x. PMID   6125564.
• Bräuner-Osborne H, Egebjerg J, Nielsen EO, Madsen U, Krogsgaard-Larsen P (July 2000). "Ligands for glutamate receptors: design and therapeutic prospects". J Med Chem. 43 (14): 2609–2645. doi:10.1021/jm000007r. PMID   10893301.
• Jensen AA, Frølund B, Liljefors T, Krogsgaard-Larsen P (July 2005). "Neuronal nicotinic acetylcholine receptors: structural revelations, target identifications, and therapeutic inspirations". J Med Chem. 48 (15): 4705–4745. doi:10.1021/jm040219e. PMID   16033252.
• Demmer CS, Krogsgaard-Larsen N, Bunch L (December 2011). "Review on modern advances of chemical methods for the introduction of a phosphonic acid group". Chem Rev. 111 (12): 7981–8006. doi:10.1021/cr2002646. PMID   22010799.
• Stromgaard, K.; Krogsgaard-Larsen, P.; Madsen, U. (2022). Textbook of Drug Design and Discovery (5 ed.). Taylor & Francis Limited (Sales). ISBN   978-1-032-33994-8 . Retrieved 10 February 2025.

References

1. Bøgesø KP (October 2014). "Povl Krogsgaard-Larsen: a giant in medicinal chemistry research". Neurochem Res. 39 (10): 1847–1849. doi:10.1007/s11064-014-1437-5. PMID   25227749.
2. Bräuner-Osborne, Hans; Schousboe, Arne (2014). "Introduction to Special Issue in Honor of Professor Povl Krogsgaard-Larsen". Neurochemical Research. 39 (10): 1845–1846. doi:10.1007/s11064-014-1408-x. ISSN   0364-3190.
3. Morris, Hamilton (18 June 2021). "Gaboxadol, by Hamilton Morris". Harper's Magazine. Retrieved 10 February 2025.
4. Hamilton Morris (25 December 2021). "PODCAST 36: An Amanita Christmas with Dr. Povl Krogsgaard-Larsen". The Hamilton Morris Podcast (Podcast). Patreon. Retrieved 10 February 2025.
5. "Povl Krogsgaard-Larsen". University of Copenhagen Research Portal. 14 February 2013. Retrieved 10 February 2025.