Isoguvacine

Last updated
Isoguvacine
Isoguvacine.png
Clinical data
Drug class GABAA receptor agonist
Identifiers
  • 1,2,3,6-tetrahydropyridine-4-carboxylic acid
CAS Number
PubChem CID
IUPHAR/BPS
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard 100.150.537 OOjs UI icon edit-ltr-progressive.svg
Chemical and physical data
Formula C6H9NO2
Molar mass 127.143 g·mol−1
3D model (JSmol)
  • O=C(O)/C1=C/CNCC1

Isoguvacine is a GABAA receptor agonist used in scientific research. [1] It is a highly charged zwitterion and is unable to enter the central nervous system or produce central mediated effects. [2]

See also

References

  1. ↑ Wahab A, Heinemann U, Albus K (October 2009). "Effects of gamma-aminobutyric acid (GABA) agonists and a GABA uptake inhibitor on pharmacoresistant seizure like events in organotypic hippocampal slice cultures". Epilepsy Research. 86 (2–3): 113–23. doi:10.1016/j.eplepsyres.2009.05.008. PMID   19535226. S2CID   32999271.
  2. ↑ Wafford KA, Ebert B (February 2006). "Gaboxadol--a new awakening in sleep". Curr Opin Pharmacol. 6 (1): 30–36. doi:10.1016/j.coph.2005.10.004. PMID   16368265. Early studies demonstrated that the highly charged zwitterions isoguvacine and P4S were unable to enter the CNS or exert any pharmacological activity, whereas muscimol and (to an even larger extent) gaboxadol produced observable changes in behaviour after systemic application [25].


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