CGP-35348

CGP-35348

Identifiers
IUPAC name 3-Aminopropyl(diethoxymethyl)phosphinic acid
CAS Number	123690-79-9  Y
PubChem CID	107699
IUPHAR/BPS	1069
ChemSpider	96869  N
UNII	87TI61875H
CompTox Dashboard (EPA)	DTXSID70154064
Chemical and physical data
Formula	C8H20NO4P
Molar mass	225.225 g·mol−1
3D model (JSmol)	Interactive image
SMILES CCOC(OCC)P(=O)(CCCN)O
InChI InChI=1S/C8H20NO4P/c1-3-12-8(13-4-2)14(10,11)7-5-6-9/h8H,3-7,9H2,1-2H3,(H,10,11) N Key:QIIVUOWTHWIXFO-UHFFFAOYSA-N N
NY  (what is this?)    (verify)

CGP-35348 is a compound used in scientific research which acts as an antagonist at GABA_B receptors. ^{[1] [2] [3]}

CGP-35348 was ineffective up to 100 μM to antagonize the inhibitory release of GABA elicited by baclofen, doing so selectively as a GABA_B heteroreceptor antagonist. ^[4] Moreover, CGP-35348 was about threefold less potent in antagonizing gamma-hydroxybutyrate (GHB) and gamma-butyrolactone (GBL) than baclofen and SKF-97,541. ^[5]

References

1. Carter LP, Chen W, Coop A, Koek W, France CP (May 2006). "Discriminative stimulus effects of GHB and GABA(B) agonists are differentially attenuated by CGP35348". European Journal of Pharmacology. 538 (1–3): 85–93. doi:10.1016/j.ejphar.2006.03.039. PMID   16647701.
2. Nasrallah FA, Griffin JL, Balcar VJ, Rae C (August 2007). "Understanding your inhibitions: modulation of brain cortical metabolism by GABA(B) receptors". Journal of Cerebral Blood Flow and Metabolism. 27 (8): 1510–20. doi:10.1038/sj.jcbfm.9600453. PMID   17293844. S2CID   16069846.
3. Koek W, Mercer SL, Coop A, France CP (September 2009). "Behavioral effects of gamma-hydroxybutyrate, its precursor gamma-butyrolactone, and GABA(B) receptor agonists: time course and differential antagonism by the GABA(B) receptor antagonist 3-aminopropyl(diethoxymethyl)phosphinic acid (CGP35348)". The Journal of Pharmacology and Experimental Therapeutics. 330 (3): 876–83. doi:10.1124/jpet.109.151845. PMC   2729800 . PMID   19564487.
4. Maurizio Raiteri (2006). "Functional Pharmacology in Human Brain". Pharmacological Reviews. 58 (2): 162–193. doi:10.1124/pr.58.2.5. PMID   16714485. S2CID   14404544.
5. Koek W1, Mercer SL, Coop A. (June 2007). "Cataleptic effects of gamma-hydroxybutyrate (GHB), its precursor gamma-butyrolactone (GBL), and GABAB receptor agonists in mice: differential antagonism by the GABAB receptor antagonist CGP35348". Psychopharmacology. 192 (3): 407–14. doi:10.1007/s00213-007-0718-y. PMID   17277933. S2CID   25049526.