SKF-97,541

Last updated

SKF-97,541
SKF-97,541.svg
Clinical data
ATC code
  • none
Identifiers
  • 3-aminopropyl(methyl)phosphinic acid
CAS Number
PubChem CID
IUPHAR/BPS
ChemSpider
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard 100.229.655 OOjs UI icon edit-ltr-progressive.svg
Chemical and physical data
Formula C4H12NO2P
Molar mass 137.119 g·mol−1
3D model (JSmol)
  • CP(=O)(CCCN)O
  • InChI=1S/C4H12NO2P/c1-8(6,7)4-2-3-5/h2-5H2,1H3,(H,6,7) X mark.svgN
  • Key:NHVRIDDXGZPJTJ-UHFFFAOYSA-N X mark.svgN
 X mark.svgNYes check.svgY  (what is this?)    (verify)

SKF-97,541 is a compound used in scientific research which acts primarily as a selective GABAB receptor agonist. [1] It has sedative effects in animal studies and is widely used in research into potential treatment of various types of drug addiction. [2] [3] [4] [5] [6] [7] [8] [9]

References

  1. ↑ Seabrook GR, Howson W, Lacey MG (December 1990). "Electrophysiological characterization of potent agonists and antagonists at pre- and postsynaptic GABAB receptors on neurones in rat brain slices". British Journal of Pharmacology. 101 (4): 949–57. doi:10.1111/j.1476-5381.1990.tb14186.x. PMC   1917862 . PMID   1964824.
  2. ↑ Jackson GL, Kuehl D (May 2002). "The GABA(B) antagonist CGP 52432 attenuates the stimulatory effect of the GABA(B) agonist SKF 97541 on luteinizing hormone secretion in the male sheep". Experimental Biology and Medicine. 227 (5): 315–20. doi:10.1177/153537020222700503. PMID   11976401. S2CID   35467974.
  3. ↑ Besheer J, Lepoutre V, Hodge CW (July 2004). "GABA(B) receptor agonists reduce operant ethanol self-administration and enhance ethanol sedation in C57BL/6J mice". Psychopharmacology. 174 (3): 358–66. doi:10.1007/s00213-003-1769-3. PMID   14985930. S2CID   25036152.
  4. ↑ Carter LP, Chen W, Coop A, Koek W, France CP (May 2006). "Discriminative stimulus effects of GHB and GABA(B) agonists are differentially attenuated by CGP35348". European Journal of Pharmacology. 538 (1–3): 85–93. doi:10.1016/j.ejphar.2006.03.039. PMID   16647701.
  5. ↑ Koek W, Mercer SL, Coop A (June 2007). "Cataleptic effects of gamma-hydroxybutyrate (GHB), its precursor gamma-butyrolactone (GBL), and GABAB receptor agonists in mice: differential antagonism by the GABAB receptor antagonist CGP35348". Psychopharmacology. 192 (3): 407–14. doi:10.1007/s00213-007-0718-y. PMID   17277933. S2CID   25049526.
  6. ↑ Koek W, Mercer SL, Coop A, France CP (September 2009). "Behavioral effects of gamma-hydroxybutyrate, its precursor gamma-butyrolactone, and GABA(B) receptor agonists: time course and differential antagonism by the GABA(B) receptor antagonist 3-aminopropyl(diethoxymethyl)phosphinic acid (CGP35348)". The Journal of Pharmacology and Experimental Therapeutics. 330 (3): 876–83. doi:10.1124/jpet.109.151845. PMC   2729800 . PMID   19564487.
  7. ↑ Frankowska M, Nowak E, Filip M (2009). "Effects of GABAB receptor agonists on cocaine hyperlocomotor and sensitizing effects in rats". Pharmacological Reports. 61 (6): 1042–9. doi:10.1016/s1734-1140(09)70166-5. PMID   20081239. S2CID   4723878.
  8. ↑ Ranson DC, Ayoub SS, Corcoran O, Casalotti SO (2020). "Pharmacological targeting of the GABA B receptor alters Drosophila's behavioural responses to alcohol". Addiction Biology. 25 (2) e12725. doi: 10.1111/adb.12725 . PMC   7050513 . PMID   30761704.
  9. ↑ Gawlińska K, Jastrzębska J, Gamberini S, Gawliński D, Pieniążek R, Suder A, Wydra K, Frankowska M (September 2020). "The impact of GABAB receptors and their pharmacological stimulation on cocaine reinforcement and drug-seeking behaviors in a rat model of depression". European Journal of Pharmacology. 883 173324. doi:10.1016/j.ejphar.2020.173324. PMID   32621910. S2CID   220348380.
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