2-Hydroxysaclofen

Last updated
2-Hydroxysaclofen
2-Hydroxysaclofen.svg
Names
Preferred IUPAC name
3-Amino-2-(4-chlorophenyl)-2-hydroxypropane-1-sulfonic acid
Identifiers
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
EC Number
  • 634-206-2
PubChem CID
UNII
  • Key: WBSMZVIMANOCNX-UHFFFAOYSA-N
  • InChI=1S/C9H12ClNO4S/c10-8-3-1-7(2-4-8)9(12,5-11)6-16(13,14)15/h1-4,12H,5-6,11H2,(H,13,14,15)
  • C1=CC(=CC=C1C(CN)(CS(=O)(=O)O)O)Cl
Properties
C9H12ClNO4S
Molar mass 265.71 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

2-Hydroxysaclofen is a GABAB receptor antagonist and an analogue of saclofen.

Contents

Pharmacodynamics

2-Hydroxysaclofen binds to the GABAB receptor, but this is selective for the (S)-enantiomer, while the (R)-enantiomer does not bind to the GABAB protein. [1]

2-Hydroxysaclofen has been reported to be more potent than saclofen. [2]

See also

References

  1. ↑ Froestl, Wolfgang; Enna, S.J. (2007). "2-Hydroxysaclofen". XPharm: The Comprehensive Pharmacology Reference. pp. 1–6. doi:10.1016/B978-008055232-3.61101-8. ISBN   978-0-08-055232-3.
  2. ↑ "2-Hydroxysaclofen".
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