Ro 19-4603

Last updated
Ro 19-4603 [1]
Ro 19-4603.svg
Names
IUPAC name
tert-Butyl 8-methyl-7-oxo-5-thia-1,8,12-triazatricyclo[8.3.0.02,6]trideca-2(6),3,10,12-tetraene-11-carboxylate
Identifiers
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
KEGG
PubChem CID
  • InChI=1S/C15H17N3O3S/c1-15(2,3)21-14(20)11-10-7-17(4)13(19)12-9(5-6-22-12)18(10)8-16-11/h5-6,8H,7H2,1-4H3
    Key: ZIGMMUKDYCABPW-UHFFFAOYSA-N
  • CC(C)(C)OC(=O)C1=C2CN(C(=O)C3=C(N2C=N1)C=CS3)C
Properties
C15H17N3O3S
Molar mass 319.38 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

Ro 19-4603 is an inverse agonist of the benzodiazepine binding site. It has effects antagonistic to those of benzodiazepines.

Contents

Chemistry

Despite acting at the benzodiazepine site, it does not possess the benzodiazepine structure. It is an imidazothienodiazepine: a thiophene ring, an imidazole ring, and a diazepine ring fused together.

Effects and pharmacodynamics

Ro 19-4603 is an inverse agonist at the benzodiazepine binding site. Due to this, it has effects similar to other benzodiazepine inverse agonists, notably: anxiogenesis [2] and convulsions. [3]

In animal studies, administration of this compound was able to decrease voluntary alcohol consumption. This was observed in rats selected for high alcohol preference. [4] In addition to decreasing its consumption, Ro 19-4603 is able to antagonize the intoxicating effects of alcohol. [5]

References

  1. ↑ "Tert-butyl 5-methyl-6-oxo-5,6-dihydro-4h-imidazo[1,5-a]thieno[2,3-f][1,4]diazepine-3-carboxylate".
  2. ↑ Belzung, C.; Misslin, R.; Vogel, E. (July 1990). "Anxiogenic effects of a benzodiazepine receptor partial inverse agonist, RO 19-4603, in a light/dark choice situation". Pharmacology, Biochemistry, and Behavior. 36 (3): 593–596. doi:10.1016/0091-3057(90)90260-o. ISSN   0091-3057. PMID   2165618. S2CID   9881393.
  3. ↑ Kubová, H.; Mares, P. (October 1994). "Convulsant action of a benzodiazepine receptor agonist/inverse agonist Ro 19-4603 in developing rats". Naunyn-Schmiedeberg's Archives of Pharmacology. 350 (4): 393–397. doi:10.1007/BF00178957. ISSN   0028-1298. PMID   7845475. S2CID   1751486.
  4. ↑ Balakleevsky, A.; Colombo, G.; Fadda, F.; Gessa, G. L. (1990). "Ro 19-4603, a benzodiazepine receptor inverse agonist, attenuates voluntary ethanol consumption in rats selectively bred for high ethanol preference". Alcohol and Alcoholism (Oxford, Oxfordshire). 25 (5): 449–452. ISSN   0735-0414. PMID   1965120.
  5. ↑ Lister, R. G.; Durcan, M. J. (1989-03-13). "Antagonism of the intoxicating effects of ethanol by the potent benzodiazepine receptor ligand Ro 19-4603". Brain Research. 482 (1): 141–144. doi:10.1016/0006-8993(89)90551-9. ISSN   0006-8993. PMID   2539880. S2CID   22770686.
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