BHFF

Last updated
BHFF
BHFF structure.png
Identifiers
  • 5,7-Bis(1,1-dimethylethyl)-3-hydroxy-3(trifluoromethyl)-2(3H)-benzofuranone
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
ECHA InfoCard 100.229.838 OOjs UI icon edit-ltr-progressive.svg
Chemical and physical data
Formula C17H21F3O3
Molar mass 330.347 g·mol−1
3D model (JSmol)
  • FC(F)(F)C2(O)c1cc(C(C)(C)C)cc(C(C)(C)C)c1OC2=O
  • InChI=1S/C17H21F3O3/c1-14(2,3)9-7-10(15(4,5)6)12-11(8-9)16(22,13(21)23-12)17(18,19)20/h7-8,22H,1-6H3 Yes check.svgY
  • Key:RVNOANDLZIIFHB-UHFFFAOYSA-N Yes check.svgY
   (verify)

BHFF is a compound used in scientific research which acts as a positive allosteric modulator at the GABAB receptor. It has anxiolytic effects in animal studies, and good oral bioavailability. [1]

References

  1. ↑ Malherbe P, Masciadri R, Norcross RD, Knoflach F, Kratzeisen C, Zenner MT, et al. (June 2008). "Characterization of (R,S)-5,7-di-tert-butyl-3-hydroxy-3-trifluoromethyl-3H-benzofuran-2-one as a positive allosteric modulator of GABAB receptors". British Journal of Pharmacology. 154 (4): 797–811. doi:10.1038/bjp.2008.135. PMC   2439845 . PMID   18536733.
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