Securinine

Last updated
Securinine
Securinine.svg
Identifiers
  • (1S,2R,8S)-14-Oxa-7-azatetracyclo[6.6.1.01,11.02,7]pentadeca-9,11-dien-13-one
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard 100.222.962 OOjs UI icon edit-ltr-progressive.svg
Chemical and physical data
Formula C13H15NO2
Molar mass 217.268 g·mol−1
3D model (JSmol)
  • C1CCN2[C@H](C1)[C@]34C[C@H]2C=CC3=CC(=O)O4
  • InChI=1S/C13H15NO2/c15-12-7-9-4-5-10-8-13(9,16-12)11-3-1-2-6-14(10)11/h4-5,7,10-11H,1-3,6,8H2/t10-,11-,13+/m1/s1
  • Key:SWZMSZQQJRKFBP-WZRBSPASSA-N

Securinine is an alkaloid found in Securinega suffruticosa [1] and Phyllanthus niruri . [2]

Contents

Pharmacology

Securinine has pro-convulsant effects [3] [4] and it has a strong spastic effect, similar to the actions of strychnine. [5]

Securinine is a GABA-A antagonist. [6] [7]

See also

References

  1. Du GH, Wang DS, Fang LH, Du GH (2018). "Securinine". Natural Small Molecule Drugs from Plants. Springer Singapore. pp. 325–330. doi:10.1007/978-981-10-8022-7_54. ISBN   978-981-10-8021-0.
  2. Patel JR, Tripathi P, Sharma V, Chauhan NS, Dixit VK (November 2011). "Phyllanthus amarus: ethnomedicinal uses, phytochemistry and pharmacology: a review". Journal of Ethnopharmacology. 138 (2): 286–313. doi:10.1016/j.jep.2011.09.040. PMID   21982793.
  3. Tao SC, Peng JZ, Lu MW (January 1986). "[Central convulsive action of l-securinine]". Zhongguo Yao Li Xue Bao = Acta Pharmacologica Sinica. 7 (1): 9–12. PMID   2876581.
  4. Zhang SC, Li SZ, Gao XC, Qian LH, Yang MZ, Yuan HN, Tan DJ (July 1993). "[The adverse effects of the preparations of the active principles of Chinese herbal drugs]". Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica. 18 (7): 387–391. PMID   8267848.
  5. Klochkov S, Neganova M (May 2021). "Unique indolizidine alkaloid securinine is a promising scaffold for the development of neuroprotective and antitumor drugs". RSC Advances. 11 (31): 19185–19195. Bibcode:2021RSCAd..1119185K. doi: 10.1039/D1RA02558A . PMC   9033663 . PMID   35478659.
  6. "Securinine". PubChem, US National Library of Medicine. 2020-07-04.
  7. Beutler JA, Karbon EW, Brubaker AN, Malik R, Curtis DR, Enna SJ (March 1985). "Securinine alkaloids: a new class of GABA receptor antagonist". Brain Research. 330 (1): 135–140. doi:10.1016/0006-8993(85)90014-9. PMID   2985189. S2CID   21138482.