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Electrospray ionization (ESI) is a technique used in mass spectrometry to produce ions using an electrospray in which a high voltage is applied to a liquid to create an aerosol. It is especially useful in producing ions from macromolecules because it overcomes the propensity of these molecules to fragment when ionized. ESI is different from other ionization processes since it may produce multiple-charged ions, effectively extending the mass range of the analyser to accommodate the kDa-MDa orders of magnitude observed in proteins and their associated polypeptide fragments.
Micellar electrokinetic chromatography (MEKC) is a chromatography technique used in analytical chemistry. It is a modification of capillary electrophoresis (CE), extending its functionality to neutral analytes, where the samples are separated by differential partitioning between micelles and a surrounding aqueous buffer solution.
In mass spectrometry, matrix-assisted laser desorption/ionization (MALDI) is an ionization technique that uses a laser energy-absorbing matrix to create ions from large molecules with minimal fragmentation. It has been applied to the analysis of biomolecules and various organic molecules, which tend to be fragile and fragment when ionized by more conventional ionization methods. It is similar in character to electrospray ionization (ESI) in that both techniques are relatively soft ways of obtaining ions of large molecules in the gas phase, though MALDI typically produces far fewer multi-charged ions.
Wet chemistry is a form of analytical chemistry that uses classical methods such as observation to analyze materials. It is called wet chemistry since most analyzing is done in the liquid phase. Wet chemistry is also called bench chemistry since many tests are performed at lab benches.
Soft laser desorption (SLD) is laser desorption of large molecules that results in ionization without fragmentation. "Soft" in the context of ion formation means forming ions without breaking chemical bonds. "Hard" ionization is the formation of ions with the breaking of bonds and the formation of fragment ions.
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Christie G. Enke is a United States academic chemist who made pioneering contributions to the field of analytical chemistry.
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Jerome J. Workman Jr. is an American analytical spectroscopist, author, editor, and inventor born on August 6, 1952, in Northfield, Minnesota. Jerry Workman, Jerry Workman, Jr., and J.J. Workman are also names he uses for publishing.
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Sibyl Martha Rock was an American inventor who was a pioneer in mass spectrometry and computing. Rock was a key person in Consolidated Engineering Corporation's (CEC) mass spectrometry team at a time when mass spectrometers were first being commercialized for use by researchers and scientists. Rock was instrumental in developing mathematical techniques for analyzing the results from mass spectrometers, in developing an analog computer with Clifford Berry for analysis of equations, and in sustaining an ongoing dialog between engineers and customers involved in development of both the mass spectrometer and an early digital computer, CEC's Datatron.
John Michael Ramsey is an American analytical chemist at the University of North Carolina at Chapel Hill. He currently holds the position of Minnie N. Goldby Distinguished Professor of Chemistry. His current research with the university focuses on microscale and nanoscale devices such as microchip electrospray, microscale Ion trap mass spectrometers, and microfluidic point of care devices. He is ranked #2 in the "Giants of Nano" field on The Analytical Scientist Power List.
Gary Glish is an American analytical chemist at the University of North Carolina at Chapel Hill. He is a leading researcher in the fields of mass spectrometry, ion chemistry, and biomolecule analysis.
Peter Nemes is a Hungarian-American chemist, who is active in the fields of bioanalytical chemistry, mass spectrometry, cell/developmental biology, neuroscience, and biochemistry.
Jennifer G. Murphy is a Canadian environmental chemist and an associate professor at the University of Toronto. She is known for her research how air pollutants such as increased reactive nitrogen affect the global climate.
References
- ↑ Workman, Jerome; Veltkamp, David J.; Doherty, Steve; Anderson, Brian B.; Creasy, Ken E.; Koch, Mel; Tatera, James F.; Robinson, Alex L.; Bond, Leonard; Burgess, Lloyd W.; Bokerman, Gary N.; Ullman, Alan H.; Darsey, Gary P.; Mozayeni, Foad; Bamberger, Judith Ann; Greenwood, Margaret Stautberg (1999). "Process Analytical Chemistry". Anal. Chem. 71 (12): 121–180. doi:10.1021/a1990007s.
- ↑ Beebe, Kenneth R.; Blaser, Wayne W.; Bredeweg, Robert A.; Chauvel, Jean Paul.; Harner, Richard S.; LaPack, Mark.; Leugers, Anne.; Martin, Daniel P.; Wright, Larry G.; Yalvac, E. Deniz. (1993). "Process analytical chemistry". Analytical Chemistry. 65 (12): 199–216. doi:10.1021/ac00060a012. ISSN 0003-2700.