Puerto Rico Highway 30 (PR-30), known as Expreso Cruz Ortiz Stella, is a main freeway in eastern Puerto Rico which connects the city of Caguas to the municipality of Humacao. With a length of 30.1 km (18.7 mi), it extends from PR-1 interchange in Bairoa barrio to PR-53 junction in Buena Vista barrio.
Puerto Rico Highway 3(PR-3) at nearly 100 miles long, is the second-longest highway on Puerto Rico. It connects the San Juan neighborhood of Río Piedras to downtown Salinas indirectly around the eastern coast of the island. Highway 3 ranges from a three lane urban avenue in San Juan to a one lane rural road past Fajardo. While other roads connect San Juan, it runs the coastline of Puerto Rico east of San Juan, beginning in Río Piedras near Santurce and goes to Fajardo where it goes south paralleling the coastline to Humacao and Maunabo. It goes up to a mountain-scenic route and goes west to Salinas, where it meets PR-1.
Puerto Rico Highway 53 (PR-53) or unsigned Interstate PR3 is a main tollway that is parallel to Puerto Rico Highway 3, which goes from Fajardo to Salinas. Some segments are still in planning, but when finished it will be about 58 miles (93 km) in length. Two tunnels, about 0.6 mi (1 km) long each, in the towns of Yabucoa and Maunabo were completed in October 2008. It will connect the cities of Fajardo, Ceiba, Naguabo, Humacao, Yabucoa, Maunabo, Patillas, Arroyo, Guayama and Salinas, thus bordering the entire eastern and southeastern coasts of Puerto Rico. Its northern terminus is at PR-3 and PR-194 in Fajardo, and its south terminus is at PR-52 in Salinas.
Puerto Rico Highway 111 (PR-111) is a highway connecting Aguadilla, Puerto Rico at Puerto Rico Highway 2 and Puerto Rico Highway 115 to Utuado, Puerto Rico at Puerto Rico Highway 140.
Puerto Rico Highway 116 (PR-116) is a main highway in the southwest part of Puerto Rico, beginning in Guánica, Puerto Rico at Puerto Rico Highway 2 to Lajas, Puerto Rico at Puerto Rico Highway 101.
Puerto Rico Highway 181 (PR-181), also known as Expreso Trujillo Alto, is a road that connects the towns of San Juan, Puerto Rico in the north/northeast coast of Puerto Rico with Patillas in the southeast, passing through the municipalities of San Juan at Jesus de Piñero Avenue (PR-17) as it approaches the Teodoro Moscoso Bridge and the Luis Muñoz Marín International Airport, Trujillo Alto, Gurabo, San Lorenzo, Yabucoa and Patillas in the center of the town district near PR-3. Along with PR-10, PR-149, PR-1 and PR-52, it is one of the longest highways crossing the island from north to south through the central mountainous region. In the north part of Trujillo Alto it is a four-lane highway, turning completely rural on the way to Patillas with the exception of a small tract in Gurabo where it intersects PR-30.
Puerto Rico Highway 203 (PR-203), also known as the Expreso Chayanne, is a highway which connects Gurabo, Puerto Rico at PR-30 with its parallel route Puerto Rico Highway 183 in San Lorenzo. It is the main route to San Lorenzo and is about 7 kilometers long. It is a dangerous highway, as steep grading is present going down and then going up.
Puerto Rico Highway 901 (PR-901) is a highway in the southeast coast of Puerto Rico which begins at its junction with PR-182 in Yabucoa and ends at its intersection with PR-760 in Manuabo.
Puerto Rico Highway 344 (PR-344) is a rural road in Hormigueros, Puerto Rico, beginning from near the municipality's small downtown and ending at PR-348 near the border with San Germán in barrio Rosario. It has narrow lanes, and after about five kilometers becomes one of the most dangerous highways in Puerto Rico, as it goes near a precipice with little or no safety barriers. It serves as a route to Mayagüez via PR-348 which ends in Puerto Rico Alt Route 2.
Puerto Rico Highway 185 (PR-185) is a main highway that connects Canóvanas, Puerto Rico to Juncos, Puerto Rico and is about 25 kilometers long. It begins in downtown of Canóvanas, very close to Puerto Rico Highway 3 and ends in Puerto Rico Highway 952 and Puerto Rico Highway 30 in Juncos.
Puerto Rico Highway 189 (PR-189) is a 15 kilometres (9 mi) long main highway which parallels very closely the first half of Puerto Rico Highway 30 from Caguas, Puerto Rico near downtown to Juncos, Puerto Rico passing through all three business centers of Caguas, Gurabo and Juncos. It ends at Puerto Rico Highway 31, and has no direct intersection with Puerto Rico Highway 198 although they are not separated by more than half a kilometer.
Puerto Rico Highway 183 (PR-183) is a main highway which begins in the downtown/business area of Caguas, near Puerto Rico Highway 1 and ends in Puerto Rico Highway 198 in Las Piedras. Measuring near 25 kilometers, it is real rural parallel road of Puerto Rico Highway 30, though it goes significantly south of the latter and the only municipality it does not go through which PR-30 does in Humacao.
The Ruta Panorámica, officially the Ruta Panorámica Luis Muñoz Marín, is a 167-mile (269 km) network of some 40 secondary roads which traverse the island of Puerto Rico from west to east along its Cordillera Central. Most of the route consists of three roads, PR-105, PR-143, and PR-182. The route starts in Mayagüez and ends in Maunabo. The first major segment of the route runs from Mayagüez to Maricao as Route 105, then from Adjuntas to Aibonito as Route 143, and then follows Route 182 toward Maunabo.
Puerto Rico Highway 165 (PR-165) is the road that goes from Naranjito to Guaynabo. The highway passes by Toa Alta, Toa Baja, Dorado, Levittown, Cataño and Guaynabo.
Puerto Rico Highway 47 (PR-47), also known as Calle De Diego, is an urban road in Río Piedras, Puerto Rico.
Puerto Rico Highway 122 (PR-122) is a north–south road between the municipalities of San Germán and Lajas, Puerto Rico. In San Germán, it begins at PR-2 and ends at PR-166, and in Lajas, it extends from PR-116 to PR-321. When completed, it will be extend from PR-116 at its southern terminus to PR-2 interchange in the northern end.
Puerto Rico Highway 36 (PR-36) is an urban road in Santurce. This is a road that connects from Avenida Juan Ponce de León (PR-25) to Avenida Barbosa (PR-27). It provides access to Barrio Obrero, Las Palmas and Las Casas from Martín Peña and the southern part of Monteflores. This road is called Avenida Borinquen.
Puerto Rico Highway 152 (PR-152) is a rural road that travels from Barranquitas to Naranjito in Puerto Rico. This road extends from PR-156 in downtown Barranquitas and ends at its junction with PR-5 and PR-164 near downtown Naranjito.
Puerto Rico Highway 807 (PR-807) is a north–south road located in the municipality of Corozal in Puerto Rico. With a length of 6.9 km (4.3 mi), it begins at Calle San Manuel in downtown Corozal, passing through Dos Bocas barrio until its southern terminus at its junction with PR-805 on the Palos Blancos–Negros line.
Puerto Rico Highway 821 (PR-821) is a north–south road located in the municipality of Corozal in Puerto Rico. With a length of 6.0 km (3.7 mi), it begins at its intersection with PR-891 between downtown Corozal and Barrio Pueblo, passing through Abras barrio until its terminus at PR-630 near Mavilla barrio of Vega Alta municipality.
PR-181 in Guayabota 
PR-3 in Juan Martín 
