RAB6C

RAB6C
Identifiers
Aliases	RAB6C , WTH3, member RAS oncogene family
External IDs	OMIM: 612909 HomoloGene: 108091 GeneCards: RAB6C
Gene location (Human) Chr. Chromosome 2 (human) [1] Band 2q21.1 Start 129,979,666 bp [1] End 129,982,738 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endometrium superior frontal gyrus prefrontal cortex hippocampus proper Brodmann area 9 corpus callosum putamen substantia nigra temporal lobe amygdala n/a More reference expression data BioGPS n/a
Gene ontology Molecular function nucleotide binding GTP binding GTPase activity Cellular component cytoplasm centrosome intracellular anatomical structure cytoskeleton nucleus microtubule organizing center cytosol Golgi apparatus Biological process regulation of centrosome duplication retrograde transport, endosome to Golgi intra-Golgi vesicle-mediated transport retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum mitotic cell cycle small GTPase mediated signal transduction intracellular protein transport Rab protein signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 84084 n/a Ensembl ENSG00000222014 n/a UniProt Q9H0N0 n/a RefSeq (mRNA) NM_032144 n/a RefSeq (protein) NP_115520 n/a Location (UCSC) Chr 2: 129.98 – 129.98 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Ras-related protein Rab-6C is a protein that in humans is encoded by the RAB6C gene. ^{[3] [4] [5]}

References

1. GRCh38: Ensembl release 89: ENSG00000222014 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Shan J, Mason JM, Yuan L, Barcia M, Porti D, Calabro A, Budman D, Vinciguerra V, Xu H (Dec 2000). "Rab6c, a new member of the rab gene family, is involved in drug resistance in MCF7/AdrR cells". Gene. 257 (1): 67–75. doi: 10.1016/S0378-1119(00)00395-4 . PMID   11054569.
4. Tian K, Wang Y, Xu H (May 2007). "WTH3 is a direct target of the p53 protein". Br J Cancer. 96 (10): 1579–86. doi:10.1038/sj.bjc.6603724. PMC   2359938 . PMID   17426708.
5. "Entrez Gene: RAB6C RAB6C, member RAS oncogene family".

Further reading

• Sanger Centre, The; Washington University Genome Sequencing Cente, The (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi: 10.1101/gr.8.11.1097 . PMID   9847074.
• Fitzgerald ML; Reed GL (1999). "Rab6 is phosphorylated in thrombin-activated platelets by a protein kinase C-dependent mechanism: effects on GTP/GDP binding and cellular distribution". Biochem. J. 342 ( Pt 2) (2): 353–60. doi:10.1042/0264-6021:3420353. PMC   1220472 . PMID   10455022.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.
• Shan J; Yuan L; Budman DR; Xu HP (2002). "WTH3, a new member of the Rab6 gene family, and multidrug resistance". Biochim. Biophys. Acta. 1589 (2): 112–23. doi: 10.1016/S0167-4889(02)00164-7 . PMID   12007787.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Tian K, Jurukovski V, Wang XP, et al. (2005). "Epigenetic regulation of WTH3 in primary and cultured drug-resistant breast cancer cells". Cancer Res. 65 (21): 10024–31. doi: 10.1158/0008-5472.CAN-05-1944 . PMID   16267028.