RAP1GAP

RAP1GAP
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1SRQ, 3BRW
Identifiers
Aliases	RAP1GAP , RAP1GA1, RAP1GAP1, RAP1GAPII, RAPGAP, RAP1 GTPase activating protein
External IDs	OMIM: 600278 MGI: 109338 HomoloGene: 2163 GeneCards: RAP1GAP
Gene location (Human)
Chr.	Chromosome 1 (human)
End	21,669,363 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	137,729,861 bp
RNA expression pattern
	Top expressed in
	renal medulla; ; left lobe of thyroid gland; ; nucleus accumbens; ; right lobe of thyroid gland; ; parotid gland; ; putamen; ; caudate nucleus; ; middle frontal gyrus; ; external globus pallidus; ; prefrontal cortex;
	Top expressed in
	superior frontal gyrus; ; habenula; ; nucleus accumbens; ; olfactory tubercle; ; entorhinal cortex; ; parotid gland; ; cerebellar cortex; ; pyloric antrum; ; medial geniculate nucleus; ; lateral geniculate nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein homodimerization activity ; GTPase regulator activity ; protein binding ; GTPase activity ; GTPase activator activity ;
Cellular component	Golgi apparatus ; membrane ; Golgi membrane ; cytosol ;
Biological process	negative regulation of microvillus assembly ; regulation of GTPase activity ; positive regulation of GTPase activity ; regulation of small GTPase mediated signal transduction ; signal transduction ; axon guidance ;
	Sources:Amigo / QuickGO
Orthologs
	5909
	110351
	ENSG00000076864
	ENSMUSG00000041351
	P47736
	A2ALS5
NM_001145657 ; NM_001145658 ; NM_002885 ; NM_001330383 ; NM_001350524 ;
	NM_001350525 ; NM_001350526 ; NM_001350527 ; NM_001350528 Contents Interactions ; References ; Further reading ;
	NM_001081155 ; NM_001256218 ; NM_029563 ; NM_001331215
NP_001139129 ; NP_001139130 ; NP_001317312 ; NP_002876 ; NP_001337453 ;
	NP_001337454 ; NP_001337455 ; NP_001337456 ; NP_001337457
NP_001074624 ; NP_001243147 ; NP_001318144 ; NP_083839 ; NP_001366162 ;
	NP_001366163 ; NP_001366164 ; NP_001366165
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated January 06, 2024

Rap1 GTPase-activating protein 1 is an enzyme that in humans is encoded by the RAP1GAP gene.^[5]^[6]

Interactions

RAP1GAP has been shown to interact with MLLT4.^[7]

Related Research Articles

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Ras-related C3 botulinum toxin substrate 3 (Rac3) is a G protein that in humans is encoded by the RAC3 gene. It is an important component of intracellular signalling pathways. Rac3 is a member of the Rac subfamily of the Rho family of small G proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases.

Ras-related protein Ral-A (RalA) is a protein that in humans is encoded by the RALA gene on chromosome 7. This protein is one of two paralogs of the Ral protein, the other being RalB, and part of the Ras GTPase family. RalA functions as a molecular switch to activate a number of biological processes, majorly cell division and transport, via signaling pathways. Its biological role thus implicates it in many cancers.

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Rho guanine nucleotide exchange factor 12 is a protein that in humans is encoded by the ARHGEF12 gene. This protein is also called RhoGEF12 or Leukemia-associated Rho guanine nucleotide exchange factor (LARG).

Rnd1 is a small signaling G protein, and is a member of the Rnd subgroup of the Rho family of GTPases. It is encoded by the gene RND1.

Src kinase-associated phosphoprotein 1 is an adapter protein that in humans is encoded by the SKAP1 gene.

Ras-related protein M-Ras, also known as muscle RAS oncogene homolog and R-Ras3, is a protein that in humans is encoded by the MRAS gene on chromosome 3. It is ubiquitously expressed in many tissues and cell types. This protein functions as a signal transducer for a wide variety of signaling pathways, including those promoting neural and bone formation as well as tumor growth. The MRAS gene also contains one of 27 SNPs associated with increased risk of coronary artery disease.

Regulator of G-protein signaling 20 is a protein that in humans is encoded by the RGS20 gene.

Signal-induced proliferation-associated protein 1 is a protein that in humans is encoded by the SIPA1 gene.

SH2 domain containing 3C, also known as SH2D3C, is a protein that in humans is encoded by the SH2D3C gene.

Rap guanine nucleotide exchange factor 2 is a protein that in humans is encoded by the RAPGEF2 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000076864 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000041351 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Rubinfeld B, Munemitsu S, Clark R, Conroy L, Watt K, Crosier WJ, McCormick F, Polakis P (June 1991). "Molecular cloning of a GTPase activating protein specific for the Krev-1 protein p21rap1". Cell. 65 (6): 1033–42. doi:10.1016/0092-8674(91)90555-D. PMID 1904317. S2CID 45725280.
↑ "Entrez Gene: RAP1GAP RAP1 GTPase activating protein".
↑ Su L, Hattori M, Moriyama M, Murata N, Harazaki M, Kaibuchi K, Minato N (April 2003). "AF-6 controls integrin-mediated cell adhesion by regulating Rap1 activation through the specific recruitment of Rap1GTP and SPA-1". The Journal of Biological Chemistry. 278 (17): 15232–8. doi: 10.1074/jbc.M211888200 . hdl: 2433/148462 . PMID 12590145.

Hattori M, Minato N (October 2003). "Rap1 GTPase: functions, regulation, and malignancy". Journal of Biochemistry. 134 (4): 479–84. doi:10.1093/jb/mvg180. PMID 14607972.
Rubinfeld B, Crosier WJ, Albert I, Conroy L, Clark R, McCormick F, Polakis P (October 1992). "Localization of the rap1GAP catalytic domain and sites of phosphorylation by mutational analysis". Molecular and Cellular Biology. 12 (10): 4634–42. doi:10.1128/mcb.12.10.4634. PMC 360390 . PMID 1406653.
Weiss J, Rubinfeld B, Polakis PG, McCormick F, Cavenee WK, Arden KC (1994). "The RAP1GA1 locus for human Rap1-GTPase activating protein 1 maps to chromosome 1p36.1-->p35". Cytogenetics and Cell Genetics. 66 (1): 18–21. doi:10.1159/000133655. PMID 8275700.
Peterson SN, Trabalzini L, Brtva TR, Fischer T, Altschuler DL, Martelli P, Lapetina EG, Der CJ, White GC (November 1996). "Identification of a novel RalGDS-related protein as a candidate effector for Ras and Rap1". The Journal of Biological Chemistry. 271 (47): 29903–8. doi: 10.1074/jbc.271.47.29903 . PMID 8939933.
Kurachi H, Wada Y, Tsukamoto N, Maeda M, Kubota H, Hattori M, Iwai K, Minato N (October 1997). "Human SPA-1 gene product selectively expressed in lymphoid tissues is a specific GTPase-activating protein for Rap1 and Rap2. Segregate expression profiles from a rap1GAP gene product". The Journal of Biological Chemistry. 272 (44): 28081–8. doi: 10.1074/jbc.272.44.28081 . PMID 9346962.
Seki N, Ohira M, Nagase T, Ishikawa K, Miyajima N, Nakajima D, Nomura N, Ohara O (October 1997). "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain". DNA Research. 4 (5): 345–9. doi: 10.1093/dnares/4.5.345 . PMID 9455484.
Mochizuki N, Ohba Y, Kiyokawa E, Kurata T, Murakami T, Ozaki T, Kitabatake A, Nagashima K, Matsuda M (August 1999). "Activation of the ERK/MAPK pathway by an isoform of rap1GAP associated with G alpha(i)". Nature. 400 (6747): 891–4. Bibcode:1999Natur.400..891M. doi:10.1038/23738. PMID 10476970. S2CID 204995543.
Meng J, Glick JL, Polakis P, Casey PJ (December 1999). "Functional interaction between Galpha(z) and Rap1GAP suggests a novel form of cellular cross-talk". The Journal of Biological Chemistry. 274 (51): 36663–9. doi: 10.1074/jbc.274.51.36663 . PMID 10593970.
Berruti G (May 2000). "A novel rap1/B-Raf/14-3-3 theta protein complex is formed in vivo during the morphogenetic differentiation of postmeiotic male germ cells". Experimental Cell Research. 257 (1): 172–9. doi:10.1006/excr.2000.4877. PMID 10854065.
Kao S, Jaiswal RK, Kolch W, Landreth GE (May 2001). "Identification of the mechanisms regulating the differential activation of the mapk cascade by epidermal growth factor and nerve growth factor in PC12 cells". The Journal of Biological Chemistry. 276 (21): 18169–77. doi: 10.1074/jbc.M008870200 . PMID 11278445.
Klinger M, Kudlacek O, Seidel MG, Freissmuth M, Sexl V (September 2002). "MAP kinase stimulation by cAMP does not require RAP1 but SRC family kinases". The Journal of Biological Chemistry. 277 (36): 32490–7. doi: 10.1074/jbc.M200556200 . PMID 12082090.
Liu L, Schwartz BR, Tupper J, Lin N, Winn RK, Harlan JM (October 2002). "The GTPase Rap1 regulates phorbol 12-myristate 13-acetate-stimulated but not ligand-induced beta 1 integrin-dependent leukocyte adhesion". The Journal of Biological Chemistry. 277 (43): 40893–900. doi: 10.1074/jbc.M206208200 . PMID 12091396.
de Bruyn KM, Rangarajan S, Reedquist KA, Figdor CG, Bos JL (August 2002). "The small GTPase Rap1 is required for Mn(2+)- and antibody-induced LFA-1- and VLA-4-mediated cell adhesion". The Journal of Biological Chemistry. 277 (33): 29468–76. doi: 10.1074/jbc.M204990200 . hdl: 2066/142510 . PMID 12171996.
Meng J, Casey PJ (November 2002). "Activation of Gz attenuates Rap1-mediated differentiation of PC12 cells". The Journal of Biological Chemistry. 277 (45): 43417–24. doi: 10.1074/jbc.M204074200 . PMID 12198116.
Schmitt JM, Stork PJ (November 2002). "Galpha and Gbeta gamma require distinct Src-dependent pathways to activate Rap1 and Ras". The Journal of Biological Chemistry. 277 (45): 43024–32. doi: 10.1074/jbc.M204006200 . PMID 12221082.
Delehanty LL, Mogass M, Gonias SL, Racke FK, Johnstone B, Goldfarb AN (March 2003). "Stromal inhibition of megakaryocytic differentiation is associated with blockade of sustained Rap1 activation". Blood. 101 (5): 1744–51. doi: 10.1182/blood-2002-04-1278 . PMID 12393469.
Grader-Beck T, van Puijenbroek AA, Nadler LM, Boussiotis VA (February 2003). "cAMP inhibits both Ras and Rap1 activation in primary human T lymphocytes, but only Ras inhibition correlates with blockade of cell cycle progression". Blood. 101 (3): 998–1006. doi: 10.1182/blood-2002-06-1665 . PMID 12393539.
Gendron L, Oligny JF, Payet MD, Gallo-Payet N (February 2003). "Cyclic AMP-independent involvement of Rap1/B-Raf in the angiotensin II AT2 receptor signaling pathway in NG108-15 cells". The Journal of Biological Chemistry. 278 (6): 3606–14. doi: 10.1074/jbc.M202446200 . PMID 12464615.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000076864 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000041351 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1904317-5] Rubinfeld B, Munemitsu S, Clark R, Conroy L, Watt K, Crosier WJ, McCormick F, Polakis P (June 1991). "Molecular cloning of a GTPase activating protein specific for the Krev-1 protein p21rap1". Cell. 65 (6): 1033–42. doi:10.1016/0092-8674(91)90555-D. PMID 1904317. S2CID 45725280.

[6] "Entrez Gene: RAP1GAP RAP1 GTPase activating protein".

[pmid12590145-7] Su L, Hattori M, Moriyama M, Murata N, Harazaki M, Kaibuchi K, Minato N (April 2003). "AF-6 controls integrin-mediated cell adhesion by regulating Rap1 activation through the specific recruitment of Rap1GTP and SPA-1". The Journal of Biological Chemistry. 278 (17): 15232–8. doi: 10.1074/jbc.M211888200 . hdl: 2433/148462 . PMID 12590145.

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RAP1GAP

Contents

Interactions

Related Research Articles

References

Further reading