RAP1GDS1

RAP1GDS1
Identifiers
Aliases	RAP1GDS1 , GDS1, SmgGDS, Rap1 GTPase-GDP dissociation stimulator 1
External IDs	OMIM: 179502; MGI: 2385189; HomoloGene: 41422; GeneCards: RAP1GDS1; OMA:RAP1GDS1 - orthologs
Gene location (Human) Chr. Chromosome 4 (human) [1] Band 4q23 Start 98,261,384 bp [1] End 98,443,861 bp [1]
Gene location (Mouse) Chr. Chromosome 3 (mouse) [2] Band 3|3 H1 Start 138,631,663 bp [2] End 138,780,962 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lateral nuclear group of thalamus pons pars compacta trigeminal ganglion pars reticulata middle temporal gyrus spinal ganglia superior vestibular nucleus sperm corpus callosum Top expressed in medial dorsal nucleus medial geniculate nucleus lateral geniculate nucleus perirhinal cortex inferior colliculi olfactory epithelium visual cortex pontine nuclei primary motor cortex CA3 field More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding GTPase activator activity Cellular component cytosol extracellular exosome endoplasmic reticulum mitochondrion Biological process negative regulation of endoplasmic reticulum calcium ion concentration positive regulation of mitochondrial calcium ion concentration vascular associated smooth muscle contraction myosin filament assembly small GTPase mediated signal transduction positive regulation of GTPase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5910 229877 Ensembl ENSG00000138698 ENSMUSG00000028149 UniProt P52306 E9Q912 RefSeq (mRNA) NM_001100426 NM_001100427 NM_001100428 NM_001100429 NM_001100430 NM_021159 NM_001040690 NM_001286759 NM_145544 NM_001356388 RefSeq (protein) NP_001093896 NP_001093897 NP_001093898 NP_001093899 NP_001093900 NP_066982 NP_001035780 NP_001273688 NP_001343317 NP_663519 Location (UCSC) Chr 4: 98.26 – 98.44 Mb Chr 3: 138.63 – 138.78 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Rap1 GTPase-GDP dissociation stimulator 1 is an enzyme that in humans is encoded by the RAP1GDS1 gene. ^{[5] [6] [7]}

Interactions

RAP1GDS1 has been shown to interact with KIFAP3, ^[8] HRAS ^[9] and RHOA. ^[9]

References

1. GRCh38: Ensembl release 89: ENSG00000138698 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028149 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Riess O, Epplen C, Siedlaczck I, Epplen JT (Jan 1994). "Chromosomal assignment of the human smg GDP dissociation stimulator gene to human chromosome 4q21-q25". Hum Genet. 92 (6): 629–30. doi:10.1007/BF00420952. PMID   8262526. S2CID   21189125.
6. Tew GW, Lorimer EL, Berg TJ, Zhi H, Li R, Williams CL (Jan 2008). "SmgGDS regulates cell proliferation, migration, and NF-kappaB transcriptional activity in non-small cell lung carcinoma". J Biol Chem. 283 (2): 963–76. doi: 10.1074/jbc.M707526200 . PMID   17951244.
7. "Entrez Gene: RAP1GDS1 RAP1, GTP-GDP dissociation stimulator 1".
8. Shimizu K, Kawabe H, Minami S, Honda T, Takaishi K, Shirataki H, Takai Y (Oct 1996). "SMAP, an Smg GDS-associating protein having arm repeats and phosphorylated by Src tyrosine kinase". J. Biol. Chem. 271 (43): 27013–7. doi: 10.1074/jbc.271.43.27013 . ISSN   0021-9258. PMID   8900189.
9. Vikis HG, Stewart Scott, Guan Kun-Liang (Apr 2002). "SmgGDS displays differential binding and exchange activity towards different Ras isoforms". Oncogene. 21 (15): 2425–32. doi:10.1038/sj.onc.1205306. ISSN   0950-9232. PMID   11948427. S2CID   6647800.

Further reading

• Kikuchi A, Kaibuchi K, Hori Y, et al. (1992). "Molecular cloning of the human cDNA for a stimulatory GDP/GTP exchange protein for c-Ki-ras p21 and smg p21". Oncogene. 7 (2): 289–93. PMID   1549351.
• Shimizu K, Kawabe H, Minami S, et al. (1996). "SMAP, an Smg GDS-associating protein having arm repeats and phosphorylated by Src tyrosine kinase". J. Biol. Chem. 271 (43): 27013–7. doi: 10.1074/jbc.271.43.27013 . PMID   8900189.
• Vikis HG, Stewart S, Guan KL (2002). "SmgGDS displays differential binding and exchange activity towards different Ras isoforms". Oncogene. 21 (15): 2425–32. doi:10.1038/sj.onc.1205306. PMID   11948427. S2CID   6647800.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• de Bruyn KM, Zwartkruis FJ, de Rooij J, et al. (2003). "The small GTPase Rap1 is activated by turbulence and is involved in integrin [alpha]IIb[beta]3-mediated cell adhesion in human megakaryocytes". J. Biol. Chem. 278 (25): 22412–7. doi: 10.1074/jbc.M212036200 . PMID   12690117.
• Tiwari S, Felekkis K, Moon EY, et al. (2004). "Among circulating hematopoietic cells, B-CLL uniquely expresses functional EPAC1, but EPAC1-mediated Rap1 activation does not account for PDE4 inhibitor-induced apoptosis". Blood. 103 (7): 2661–7. doi: 10.1182/blood-2003-06-2154 . PMID   14615375.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.