RAPGEF6

RAPGEF6
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2D93, 3LNY
Identifiers
Aliases	RAPGEF6 , KIA001LB, PDZ-GEF2, PDZGEF2, RA-GEF-2, RAGEF2, Rap guanine nucleotide exchange factor 6
External IDs	OMIM: 610499; MGI: 2384761; HomoloGene: 22968; GeneCards: RAPGEF6; OMA:RAPGEF6 - orthologs
Gene location (Human) Chr. Chromosome 5 (human) [1] Band 5q31.1 Start 131,423,921 bp [1] End 131,635,231 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11|11 B1.3 Start 54,413,673 bp [2] End 54,590,111 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in corpus callosum pancreatic epithelial cell Achilles tendon sperm Brodmann area 23 cerebellar vermis superficial temporal artery subthalamic nucleus mucosa of ileum Brodmann area 46 Top expressed in lymph node mesenteric lymph nodes trigeminal ganglion Paneth cell spermatocyte blood granulocyte spleen facial motor nucleus Rostral migratory stream More reference expression data BioGPS n/a
Gene ontology Molecular function phosphatidic acid binding GTP-dependent protein binding protein binding guanyl-nucleotide exchange factor activity Cellular component cytoplasm cytosol plasma membrane endocytic vesicle apical plasma membrane membrane centrosome Biological process regulation of GTPase activity small GTPase mediated signal transduction positive regulation of GTPase activity Ras protein signal transduction microvillus assembly protein localization to plasma membrane establishment of endothelial intestinal barrier signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51735 192786 Ensembl ENSG00000158987 ENSMUSG00000037533 UniProt Q8TEU7 n/a RefSeq (mRNA) NM_016340 NM_001164386 NM_001164387 NM_001164388 NM_001164389 NM_001164390 NM_001252494 NM_001252496 NM_001252497 NM_001252498 NM_175258 RefSeq (protein) NP_001157858 NP_001157859 NP_001157860 NP_001157861 NP_001157862 NP_057424 n/a Location (UCSC) Chr 5: 131.42 – 131.64 Mb Chr 11: 54.41 – 54.59 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Rap guanine nucleotide exchange factor 6 is a protein that in humans is encoded by the RAPGEF6 gene. ^{[5] [6] [7]}

References

1. GRCh38: Ensembl release 89: ENSG00000158987 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000037533 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Gao X, Satoh T, Liao Y, Song C, Hu CD, Kariya Ki K, Kataoka T (Nov 2001). "Identification and characterization of RA-GEF-2, a Rap guanine nucleotide exchange factor that serves as a downstream target of M-Ras". J Biol Chem. 276 (45): 42219–42225. doi: 10.1074/jbc.M105760200 . PMID   11524421.
6. Kozlov G, Banville D, Gehring K, Ekiel I (Jul 2002). "Solution structure of the PDZ2 domain from cytosolic human phosphatase hPTP1E complexed with a peptide reveals contribution of the beta2-beta3 loop to PDZ domain-ligand interactions". J Mol Biol. 320 (4): 813–820. doi:10.1016/S0022-2836(02)00544-2. PMID   12095257.
7. "Entrez Gene: RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6".

Further reading

• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–648. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.
• Chen X, Wang X, Hossain S, et al. (2006). "Haplotypes spanning SPEC2, PDZ-GEF2 and ACSL6 genes are associated with schizophrenia". Hum. Mol. Genet. 15 (22): 3329–3342. doi: 10.1093/hmg/ddl409 . PMID   17030554.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–12135. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC   514446 . PMID   15302935.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi: 10.1038/ng1285 . PMID   14702039.
• Kuiperij HB, de Rooij J, Rehmann H, et al. (2003). "Characterisation of PDZ-GEFs, a family of guanine nucleotide exchange factors specific for Rap1 and Rap2". Biochim. Biophys. Acta. 1593 (2–3): 141–149. doi:10.1016/S0167-4889(02)00365-8. PMID   12581858.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.