RASA3

Last updated
RASA3
Identifiers
Aliases RASA3 , GAP1IP4BP, GAPIII, RAS p21 protein activator 3
External IDs OMIM: 605182 MGI: 1197013 HomoloGene: 7217 GeneCards: RASA3
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_007368
NM_001320821
NM_001320822

NM_009025

RefSeq (protein)

NP_001307750
NP_001307751
NP_031394

NP_033051

Location (UCSC) Chr 13: 113.98 – 114.13 Mb Chr 8: 13.62 – 13.73 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Ras GTPase-activating protein 3 is an enzyme that in humans is encoded by the RASA3 gene. [5] [6] [7]

Contents

The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. This family member is an inositol 1,3,4,5-tetrakisphosphate-binding protein, like the closely related RAS p21 protein activator 2. The two family members have distinct pleckstrin-homology domains, with this particular member having a domain consistent with its localization to the plasma membrane. [7]

Interactions

RASA3 has been shown to interact with HCK. [8]

Related Research Articles

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References

  1. 1 2 3 ENSG00000185989 GRCh38: Ensembl release 89: ENSG00000280477, ENSG00000185989 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031453 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Cullen PJ, Hsuan JJ, Truong O, Letcher AJ, Jackson TR, Dawson AP, Irvine RF (Sep 1995). "Identification of a specific Ins(1,3,4,5)P4-binding protein as a member of the GAP1 family". Nature. 376 (6540): 527–30. Bibcode:1995Natur.376..527C. doi:10.1038/376527a0. PMID   7637787. S2CID   4283160.
  6. Lockyer PJ, Bottomley JR, Reynolds JS, McNulty TJ, Venkateswarlu K, Potter BV, Dempsey CE, Cullen PJ (Feb 1998). "Distinct subcellular localisations of the putative inositol 1,3,4,5-tetrakisphosphate receptors GAP1IP4BP and GAP1m result from the GAP1IP4BP PH domain directing plasma membrane targeting". Curr Biol. 7 (12): 1007–10. doi: 10.1016/S0960-9822(06)00423-4 . PMID   9382842.
  7. 1 2 "Entrez Gene: RASA3 RAS p21 protein activator 3".
  8. Briggs SD, Bryant S S, Jove R, Sanderson S D, Smithgall T E (Jun 1995). "The Ras GTPase-activating protein (GAP) is an SH3 domain-binding protein and substrate for the Src-related tyrosine kinase, Hck". J. Biol. Chem. UNITED STATES. 270 (24): 14718–24. doi: 10.1074/jbc.270.24.14718 . ISSN   0021-9258. PMID   7782336.

Further reading