RBBP9

RBBP9
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2QS9
Identifiers
Aliases	RBBP9 , BOG, RBBP10, retinoblastoma binding protein 9, RB binding protein 9, serine hydrolase
External IDs	OMIM: 602908; MGI: 1347074; HomoloGene: 4816; GeneCards: RBBP9; OMA:RBBP9 - orthologs
Gene location (Human) Chr. Chromosome 20 (human) [1] Band 20p11.23 Start 18,486,540 bp [1] End 18,497,225 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2|2 G1 Start 144,384,185 bp [2] End 144,392,789 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in retinal pigment epithelium olfactory zone of nasal mucosa bronchial epithelial cell ventricular zone skin of thigh ganglionic eminence mucosa of paranasal sinus stromal cell of endometrium palpebral conjunctiva endothelial cell Top expressed in vestibular sensory epithelium right kidney left lung lobe tail of embryo olfactory epithelium epithelium of lens seminal vesicula genital tubercle sciatic nerve ventricular zone More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding hydrolase activity Cellular component nucleus nucleoplasm cytoplasm Biological process regulation of cell population proliferation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10741 26450 Ensembl ENSG00000089050 ENSMUSG00000027428 UniProt O75884 O88851 RefSeq (mRNA) NM_006606 NM_153328 NM_015754 RefSeq (protein) NP_006597 NP_056569 Location (UCSC) Chr 20: 18.49 – 18.5 Mb Chr 2: 144.38 – 144.39 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Putative hydrolase RBBP9 is an enzyme that in humans is encoded by the RBBP9 gene. ^{[5] [6] [7]}

Function

The protein encoded by this gene is a retinoblastoma binding protein that may play a role in the regulation of cell proliferation and differentiation. Two alternatively spliced transcript variants of this gene with identical predicted protein products have been reported, one of which is a nonsense-mediated decay candidate. ^[7]

Interactions

RBBP9 has been shown to interact with Retinoblastoma protein. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000089050 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027428 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Woitach JT, Zhang M, Niu CH, Thorgeirsson SS (Aug 1998). "A retinoblastoma-binding protein that affects cell-cycle control and confers transforming ability". Nature Genetics. 19 (4): 371–4. doi:10.1038/1258. PMID   9697699. S2CID   11374970.
6. Woitach JT, Hong R, Keck CL, Zimonjic DB, Popescu NC, Thorgeirsson SS (Oct 1999). "Assignment of the Bog gene (RBBP9) to syntenic regions of mouse chromosome 2G1-H1 and human chromosome 20p11.2 by fluorescence in situ hybridization". Cytogenetics and Cell Genetics. 85 (3–4): 252–3. doi:10.1159/000015304. PMID   10449909. S2CID   21843409.
7. "Entrez Gene: RBBP9 retinoblastoma binding protein 9".

Further reading

• Chen JZ, Yang QS, Wang S, Meng XF, Ying K, Xie Y, Ma YM (Aug 2002). "Cloning and expression of a novel retinoblastoma binding protein cDNA, RBBP10". Biochemical Genetics. 40 (7–8): 273–82. doi:10.1023/A:1019886918029. PMID   12296629. S2CID   8381137.
• Chen J, Ji C, Gu S, Zhao E, Dai J, Huang L, Qian J, Ying K, Xie Y, Mao Y (2003). "Isolation and identification of a novel cDNA that encodes human yrdC protein". Journal of Human Genetics. 48 (4): 164–9. doi: 10.1007/s10038-002-0001-3 . PMID   12730717.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.