RCE1

RCE1
Identifiers
Aliases	RCE1 , FACE2, RCE1A, RCE1B, Ras converting CAAX endopeptidase 1
External IDs	OMIM: 605385; MGI: 1336895; HomoloGene: 3769; GeneCards: RCE1; OMA:RCE1 - orthologs
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11q13.2 Start 66,842,835 bp [1] End 66,846,552 bp [1]
Gene location (Mouse) Chr. Chromosome 19 (mouse) [2] Band 19|19 A Start 4,622,591 bp [2] End 4,625,641 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon right hemisphere of cerebellum granulocyte right testis left testis skin of abdomen parotid gland gonad anterior pituitary skin of leg Top expressed in white adipose tissue proximal tubule right kidney bone marrow yolk sac adrenal gland placenta lip islet of Langerhans mesencephalon More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptidase activity cysteine-type endopeptidase activity endopeptidase activity metalloendopeptidase activity hydrolase activity Cellular component integral component of membrane integral component of endoplasmic reticulum membrane integral component of plasma membrane endoplasmic reticulum membrane membrane endoplasmic reticulum cytosol Biological process proteolysis CAAX-box protein processing protein deubiquitination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9986 19671 Ensembl ENSG00000173653 ENSMUSG00000024889 UniProt Q9Y256 P57791 RefSeq (mRNA) NM_005133 NM_001032279 NM_023131 RefSeq (protein) NP_001027450 NP_005124 NP_075620 NP_001355641 NP_001355642 NP_001355643 NP_001355644 Location (UCSC) Chr 11: 66.84 – 66.85 Mb Chr 19: 4.62 – 4.63 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

CAAX prenyl protease 2 is an enzyme that in humans is encoded by the RCE1 gene. ^{[5] [6] [7]}

This gene encodes an integral membrane protein which is classified as a member of the metalloproteinase family. This enzyme is thought to function in the maintenance and processing of CAAX-type prenylated proteins. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000173653 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024889 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Otto JC, Kim E, Young SG, Casey PJ (Apr 1999). "Cloning and characterization of a mammalian prenyl protein-specific protease". J Biol Chem. 274 (13): 8379–82. doi: 10.1074/jbc.274.13.8379 . PMID   10085068.
6. Freije JM, Blay P, Pendas AM, Cadinanos J, Crespo P, Lopez-Otin C (Jul 1999). "Identification and chromosomal location of two human genes encoding enzymes potentially involved in proteolytic maturation of farnesylated proteins". Genomics. 58 (3): 270–80. doi:10.1006/geno.1999.5834. PMID   10373325.
7. "Entrez Gene: RCE1 RCE1 homolog, prenyl protein peptidase (S. cerevisiae)".

Further reading

• Plummer LJ, Hildebrandt ER, Porter SB, et al. (2006). "Mutational Analysis of the Ras Converting Enzyme Reveals a Requirement for Glutamate and Histidine Residues". J. Biol. Chem. 281 (8): 4596–605. doi: 10.1074/jbc.M506284200 . PMC   2937830 . PMID   16361710.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Bergo MO, Lieu HD, Gavino BJ, et al. (2004). "On the physiological importance of endoproteolysis of CAAX proteins: heart-specific RCE1 knockout mice develop a lethal cardiomyopathy". J. Biol. Chem. 279 (6): 4729–36. doi: 10.1074/jbc.M310081200 . PMID   14625273.
• Maske CP, Hollinshead MS, Higbee NC, et al. (2003). "A carboxyl-terminal interaction of lamin B1 is dependent on the CAAX endoprotease Rce1 and carboxymethylation". J. Cell Biol. 162 (7): 1223–32. doi:10.1083/jcb.200303113. PMC   2173957 . PMID   14504265.
• Hollander IJ, Frommer E, Aulabaugh A, Mallon R (2003). "Human Ras converting enzyme endoproteolytic specificity at the P2' and P3' positions of K-Ras-derived peptides". Biochim. Biophys. Acta. 1649 (1): 24–9. doi:10.1016/s1570-9639(03)00150-x. PMID   12818187.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Hollander I, Frommer E, Mallon R (2000). "Human ras-converting enzyme (hRCE1) endoproteolytic activity on K-ras-derived peptides". Anal. Biochem. 286 (1): 129–37. doi:10.1006/abio.2000.4795. PMID   11038283.