RECQL5

RECQL5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4BK0, 5LB8, 5LB5, 5LBA, 5LB3
Identifiers
Aliases	RECQL5 , RECQ5, RecQ like helicase 5
External IDs	OMIM: 603781 MGI: 2156841 HomoloGene: 31232 GeneCards: RECQL5
Gene location (Human)
Chr.	Chromosome 17 (human)
End	75,667,189 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	115,824,303 bp
RNA expression pattern
	Top expressed in
	right lobe of thyroid gland; ; right uterine tube; ; left lobe of thyroid gland; ; anterior pituitary; ; sural nerve; ; skin of abdomen; ; body of stomach; ; right lobe of liver; ; minor salivary gland; ; gallbladder;
	Top expressed in
	spermatid; ; secondary oocyte; ; lip; ; corneal stroma; ; plantaris muscle; ; extensor digitorum longus muscle; ; superior frontal gyrus; ; morula; ; yolk sac; ; spermatocyte;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	RNA polymerase II complex binding ; nucleotide binding ; helicase activity ; DNA helicase activity ; nucleic acid binding ; hydrolase activity ; ATP binding ; DNA binding ; 3'-5' DNA helicase activity ; four-way junction helicase activity ; protein binding ; identical protein binding ;
Cellular component	RNA polymerase II, holoenzyme ; nucleoplasm ; nucleus ; chromosome ; cytoplasm ; cytosol ;
Biological process	DNA recombination ; DNA metabolic process ; negative regulation of transcription elongation from RNA polymerase II promoter ; cellular response to DNA damage stimulus ; cell division ; chromosome separation ; DNA replication ; cell cycle ; DNA repair ; DNA duplex unwinding ; double-strand break repair via homologous recombination ; cellular response to camptothecin ; replication-born double-strand break repair via sister chromatid exchange ; negative regulation of double-strand break repair via homologous recombination ; mitotic cell cycle ; mitotic sister chromatid segregation ; response to X-ray ; negative regulation of mitotic cell cycle ; DNA unwinding involved in DNA replication ; metabolism ;
	Sources:Amigo / QuickGO
Orthologs
	9400
	170472
	ENSG00000108469
	ENSMUSG00000020752
	O94762
	Q8VID5
	NM_001003715 ; NM_001003716 ; NM_004259
	NM_130454
	NP_001003715 ; NP_001003716 ; NP_004250
	NP_569721
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 14, 2022

ATP-dependent DNA helicase Q5 is an enzyme that in humans is encoded by the RECQL5 gene.^[5]^[6]

Interactions

RECQL5 has been shown to interact with EEF1G.^[7]

Related Research Articles

RecQ helicase is a family of helicase enzymes initially found in Escherichia coli that has been shown to be important in genome maintenance. They function through catalyzing the reaction ATP + H₂O → ADP + P and thus driving the unwinding of paired DNA and translocating in the 3' to 5' direction. These enzymes can also drive the reaction NTP + H₂O → NDP + P to drive the unwinding of either DNA or RNA.

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Coatomer subunit alpha is a protein that in humans is encoded by the COPA gene.

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60S ribosomal protein L29 is a protein that in humans is encoded by the RPL29 gene.

Histone acetyltransferase KAT7 is an enzyme that in humans is encoded by the KAT7 gene. It specifically acetylates H4 histones at the lysine12 residue (H4K12) and is necessary for origin licensing and DNA replication. KAT7 associates with origins of replication during G1 phase of the cell cycle through complexing with CDT1. Geminin is thought to inhibit the acetyltransferase activity of KAT7 when KAT7 and CDT1 are complexed together.

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<span class="mw-page-title-main">RECQL4</span> Protein-coding gene in the species Homo sapiens

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Hepatitis B virus X-interacting protein is a protein that in humans is encoded by the HBXIP gene.

Ergosterol biosynthetic protein 28 is a protein that in humans is encoded by the ERG28 gene.

Probable RNA-binding protein 23 is a protein that in humans is encoded by the RBM23 gene.

MAD2L1-binding protein is a protein that in humans is encoded by the MAD2L1BP gene.

Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 is a protein that in humans is encoded by the ARAP1 gene.

Ferritin heavy chain is a ferroxidase enzyme that in humans is encoded by the FTH1 gene. FTH1 gene is located on chromosome 11, and its mutation causes Hemochromatosis type 5.

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DNA polymerase alpha subunit 2 is an enzyme that in humans is encoded by the POLA2 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000108469 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020752 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Kitao S, Ohsugi I, Ichikawa K, Goto M, Furuichi Y, Shimamoto A (Dec 1998). "Cloning of two new human helicase genes of the RecQ family: biological significance of multiple species in higher eukaryotes". Genomics. 54 (3): 443–52. doi:10.1006/geno.1998.5595. PMID 9878247.
↑ "Entrez Gene: RECQL5 RecQ protein-like 5".
↑ Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl: 11858/00-001M-0000-0010-8592-0 . PMID 16169070. S2CID 8235923.

Sekelsky JJ, Brodsky MH, Rubin GM, Hawley RS (Sep 1999). "Drosophila and human RecQ5 exist in different isoforms generated by alternative splicing". Nucleic Acids Research. 27 (18): 3762–9. doi:10.1093/nar/27.18.3762. PMC 148633 . PMID 10471747.
Shimamoto A, Nishikawa K, Kitao S, Furuichi Y (Apr 2000). "Human RecQ5beta, a large isomer of RecQ5 DNA helicase, localizes in the nucleoplasm and interacts with topoisomerases 3alpha and 3beta". Nucleic Acids Research. 28 (7): 1647–55. doi:10.1093/nar/28.7.1647. PMC 102787 . PMID 10710432.
Garcia PL, Liu Y, Jiricny J, West SC, Janscak P (Jul 2004). "Human RECQ5beta, a protein with DNA helicase and strand-annealing activities in a single polypeptide". The EMBO Journal. 23 (14): 2882–91. doi:10.1038/sj.emboj.7600301. PMC 514958 . PMID 15241474.
Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl: 11858/00-001M-0000-0010-8592-0 . PMID 16169070. S2CID 8235923.
Hu Y, Lu X, Barnes E, Yan M, Lou H, Luo G (May 2005). "Recql5 and Blm RecQ DNA helicases have nonredundant roles in suppressing crossovers". Molecular and Cellular Biology. 25 (9): 3431–42. doi:10.1128/MCB.25.9.3431-3442.2005. PMC 1084310 . PMID 15831450.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (Jan 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129 . PMID 16344560.
Kanagaraj R, Saydam N, Garcia PL, Zheng L, Janscak P (2006). "Human RECQ5beta helicase promotes strand exchange on synthetic DNA structures resembling a stalled replication fork". Nucleic Acids Research. 34 (18): 5217–31. doi:10.1093/nar/gkl677. PMC 1635296 . PMID 17003056.
Hu Y, Raynard S, Sehorn MG, Lu X, Bussen W, Zheng L, Stark JM, Barnes EL, Chi P, Janscak P, Jasin M, Vogel H, Sung P, Luo G (Dec 2007). "RECQL5/Recql5 helicase regulates homologous recombination and suppresses tumor formation via disruption of Rad51 presynaptic filaments". Genes & Development. 21 (23): 3073–84. doi:10.1101/gad.1609107. PMC 2081974 . PMID 18003859.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000108469 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020752 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9878247-5] Kitao S, Ohsugi I, Ichikawa K, Goto M, Furuichi Y, Shimamoto A (Dec 1998). "Cloning of two new human helicase genes of the RecQ family: biological significance of multiple species in higher eukaryotes". Genomics. 54 (3): 443–52. doi:10.1006/geno.1998.5595. PMID 9878247.

[entrez-6] "Entrez Gene: RECQL5 RecQ protein-like 5".

[pmid16169070-7] Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl: 11858/00-001M-0000-0010-8592-0 . PMID 16169070. S2CID 8235923.

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RECQL5

Contents

Interactions

Related Research Articles

References

Further reading