RNF103-CHMP3 readthrough

RNF103-CHMP3
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2XZE, 3FRT, 3FRV, 2GD5
Identifiers
Aliases	RNF103-CHMP3 , RNF103-VPS24, RNF103-CHMP3 readthrough, NEDF, hVps24, VPS24, CGI149, CHMP3
External IDs	HomoloGene: 130401 GeneCards: RNF103-CHMP3
Gene location (Human) Chr. Chromosome 2 (human) [1] Band 2p11.2 Start 86,505,668 bp [1] End 86,721,122 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skeletal muscle tissue thymus blood gastrocnemius muscle left ventricle bone marrow sural nerve superior frontal gyrus prefrontal cortex bone marrow cells n/a More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding phosphatidylcholine binding protein homodimerization activity ubiquitin-specific protease binding identical protein binding Cellular component cytoplasm membrane plasma membrane endosome late endosome membrane extracellular exosome ESCRT III complex cytosol intracellular anatomical structure late endosome cytoplasmic vesicle multivesicular body Biological process autophagosome maturation viral life cycle protein polymerization multivesicular body assembly cell cycle cell division regulation of mitotic spindle assembly endosomal transport regulation of centrosome duplication apoptotic process protein heterooligomerization vacuolar transport septum digestion after cytokinesis protein transport nucleus organization mitotic metaphase plate congression multivesicular body sorting pathway regulation of exosomal secretion macroautophagy multivesicular body-lysosome fusion regulation of early endosome to late endosome transport transport viral budding via host ESCRT complex endosome transport via multivesicular body sorting pathway late endosome to vacuole transport midbody abscission Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 100526767 n/a Ensembl ENSG00000249884 n/a UniProt Q9Y3E7 n/a RefSeq (mRNA) NM_001198954 n/a RefSeq (protein) NP_001005753 NP_001180446 NP_057163 n/a Location (UCSC) Chr 2: 86.51 – 86.72 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

RNF103-CHMP3 readthrough is a protein that in humans is encoded by the RNF103-CHMP3 gene. ^[3]

Function

This locus represents naturally occurring read-through transcription between the neighboring RNF103 (ring finger protein 103) and CHMP3 (charged multivesicular body protein 3) genes. The read-through transcript encodes a fusion protein that shares sequence identity with each individual gene product.

References

1. GRCh38: Ensembl release 89: ENSG00000249884 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Entrez Gene: RNF103-CHMP3 readthrough" . Retrieved 2017-07-04.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.